Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     665
NP_671714                                                              19     665
XP_006715890                                                           19     665
XP_005250160                                                           19     665
XP_005250159                                                           19     665
NP_619542                                                              17    4312
XP_005274600                                                           17    4312
NP_116281                                                              16    5631
NP_001273420                                                           16    5631
XP_005254786                                                           16    5631
NP_848927                                                              15    9605
NP_001119595                                                           15    9605
NP_066301                                                              15    9605
NP_996999                                                              15    9605
NP_056212                                                              15    9605
NP_059982                                                              15    9605
NP_974487                                                              15    9605
XP_006716815                                                           15    9605
XP_005251156                                                           15    9605
XP_005251155                                                           15    9605
XP_005251089                                                           15    9605
XP_005251088                                                           15    9605
NP_112217                                                              15    9605
>NP_005742
          Length = 3907

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SVVLTESDA 9
            SVV+TESDA
Sbjct: 1388 SVVITESDA 1396
>NP_671714
          Length = 3899

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SVVLTESDA 9
            SVV+TESDA
Sbjct: 1388 SVVITESDA 1396
>XP_006715890
          Length = 3860

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SVVLTESDA 9
            SVV+TESDA
Sbjct: 1388 SVVITESDA 1396
>XP_005250160
          Length = 3939

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SVVLTESDA 9
            SVV+TESDA
Sbjct: 1388 SVVITESDA 1396
>XP_005250159
          Length = 3952

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SVVLTESDA 9
            SVV+TESDA
Sbjct: 1388 SVVITESDA 1396
>NP_619542
          Length = 1041

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    SVVLTESDA 9
            +VVLTE+D+
Sbjct: 1020 NVVLTENDS 1028
>XP_005274600
          Length = 1059

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    SVVLTESDA 9
            +VVLTE+D+
Sbjct: 1038 NVVLTENDS 1046
>NP_116281
          Length = 570

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VVLTESD 8
           ++LTESD
Sbjct: 520 IILTESD 526
>NP_001273420
          Length = 336

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VVLTESD 8
           ++LTESD
Sbjct: 286 IILTESD 292
>XP_005254786
          Length = 565

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VVLTESD 8
           ++LTESD
Sbjct: 515 IILTESD 521
>NP_848927
          Length = 582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SVVLTESDA 9
           SV+L++SD+
Sbjct: 521 SVILSKSDS 529
>NP_001119595
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  VLTESDA 9
          VLTE DA
Sbjct: 76 VLTEEDA 82
>NP_066301
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VVLTESD 8
           VVLTE D
Sbjct: 346 VVLTEKD 352
>NP_996999
          Length = 866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VVLTESDA 9
          V+LTE D+
Sbjct: 63 VILTEDDS 70
>NP_056212
          Length = 453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VLTESDA 9
           VLT+SDA
Sbjct: 216 VLTKSDA 222
>NP_059982
          Length = 443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLTESDA 9
           VLTE DA
Sbjct: 158 VLTEEDA 164
>NP_974487
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLTESDA 9
           VLTE DA
Sbjct: 179 VLTEEDA 185
>XP_006716815
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VLTESDA 9
           VLT+SDA
Sbjct: 195 VLTKSDA 201
>XP_005251156
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SVVLTESDA 9
           SV+L++SD+
Sbjct: 488 SVILSKSDS 496
>XP_005251155
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SVVLTESDA 9
           SV+L++SD+
Sbjct: 499 SVILSKSDS 507
>XP_005251089
          Length = 480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VVLTESD 8
           VVLTE D
Sbjct: 444 VVLTEKD 450
>XP_005251088
          Length = 636

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VVLTESD 8
           VVLTE D
Sbjct: 444 VVLTEKD 450
>NP_112217
          Length = 1594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    VLTESDA 9
            VLTE DA
Sbjct: 1284 VLTEEDA 1290
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.295    0.110    0.246 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 433,174
Number of extensions: 577
Number of successful extensions: 23
Number of sequences better than 10000.0: 23
Number of HSP's gapped: 23
Number of HSP's successfully gapped: 23
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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