Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_064450                                                              19     665
XP_005273257                                                           19     665
NP_115583                                                              17    3301
NP_001275763                                                           17    3301
XP_006722983                                                           17    3301
NP_694691                                                              16    7355
NP_694690                                                              16    7355
NP_066576                                                              16    7355
XP_005261866                                                           16    7355
XP_005261865                                                           16    7355
XP_005261864                                                           16    7355
XP_005261863                                                           16    7355
XP_005261862                                                           16    7355
XP_005261861                                                           16    7355
XP_005261860                                                           16    7355
XP_006723602                                                           16    7355
XP_005260717                                                           16    7355
NP_542789                                                              16    7355
NP_001172005                                                           15    9605
NP_001172010                                                           15    9605
NP_001172004                                                           15    9605
NP_002015                                                              15    9605
NP_001172011                                                           15    9605
NP_060919                                                              15    9605
NP_001269458                                                           15    9605
NP_056484                                                              15    9605
>NP_064450
          Length = 1722

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SVTSAFKNS 9
           SV+SAFKNS
Sbjct: 844 SVSSAFKNS 852
>XP_005273257
          Length = 1726

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SVTSAFKNS 9
           SV+SAFKNS
Sbjct: 848 SVSSAFKNS 856
>NP_115583
          Length = 657

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SVTSAFKNS 9
           S+T AF NS
Sbjct: 315 SITGAFSNS 323
>NP_001275763
          Length = 625

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SVTSAFKNS 9
           S+T AF NS
Sbjct: 315 SITGAFSNS 323
>XP_006722983
          Length = 625

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SVTSAFKNS 9
           S+T AF NS
Sbjct: 315 SITGAFSNS 323
>NP_694691
          Length = 1161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VTSAFKN 8
           VTS FKN
Sbjct: 157 VTSRFKN 163
>NP_694690
          Length = 1170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VTSAFKN 8
           VTS FKN
Sbjct: 157 VTSRFKN 163
>NP_066576
          Length = 1198

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VTSAFKN 8
           VTS FKN
Sbjct: 157 VTSRFKN 163
>XP_005261866
          Length = 1069

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  VTSAFKN 8
          VTS FKN
Sbjct: 19 VTSRFKN 25
>XP_005261865
          Length = 1174

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VTSAFKN 8
           VTS FKN
Sbjct: 170 VTSRFKN 176
>XP_005261864
          Length = 1183

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VTSAFKN 8
           VTS FKN
Sbjct: 170 VTSRFKN 176
>XP_005261863
          Length = 1207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VTSAFKN 8
           VTS FKN
Sbjct: 157 VTSRFKN 163
>XP_005261862
          Length = 1211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VTSAFKN 8
           VTS FKN
Sbjct: 170 VTSRFKN 176
>XP_005261861
          Length = 1220

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VTSAFKN 8
           VTS FKN
Sbjct: 170 VTSRFKN 176
>XP_005261860
          Length = 1220

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VTSAFKN 8
           VTS FKN
Sbjct: 170 VTSRFKN 176
>XP_006723602
          Length = 691

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SVTSAFKNS 9
           S+T++FK S
Sbjct: 428 SITTSFKES 436
>XP_005260717
          Length = 931

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SVTSAFKNS 9
           S+T++FK S
Sbjct: 427 SITTSFKES 435
>NP_542789
          Length = 906

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SVTSAFKNS 9
           S+T++FK S
Sbjct: 402 SITTSFKES 410
>NP_001172005
          Length = 611

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SVTSAFKNS 9
          S+T AF+N+
Sbjct: 27 SITVAFENN 35
>NP_001172010
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SVTSAFKNS 9
          S+T AF+N+
Sbjct: 27 SITVAFENN 35
>NP_001172004
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SVTSAFKNS 9
          S+T AF+N+
Sbjct: 27 SITVAFENN 35
>NP_002015
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SVTSAFKNS 9
          S+T AF+N+
Sbjct: 27 SITVAFENN 35
>NP_001172011
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SVTSAFKNS 9
          S+T AF+N+
Sbjct: 27 SITVAFENN 35
>NP_060919
          Length = 1119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SVTSAFKNS 9
           S+TSA +NS
Sbjct: 580 SMTSAVQNS 588
>NP_001269458
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SVTSAFKNS 9
           S+TSA +NS
Sbjct: 313 SMTSAVQNS 321
>NP_056484
          Length = 795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TSAFKNS 9
           T+AF+NS
Sbjct: 785 TAAFRNS 791
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.296    0.101    0.234 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 359,057
Number of extensions: 286
Number of successful extensions: 26
Number of sequences better than 10000.0: 26
Number of HSP's gapped: 26
Number of HSP's successfully gapped: 26
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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