Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              19     869
XP_005271621                                                           19     869
XP_006718907                                                           19     869
XP_006718906                                                           19     869
XP_005271619                                                           19     869
XP_005271618                                                           19     869
NP_073619                                                              17    2528
XP_006719254                                                           17    2528
XP_006719253                                                           17    2528
XP_006719252                                                           17    2528
XP_006719251                                                           17    2528
XP_006719250                                                           17    2528
NP_001278236                                                           17    3301
NP_001243469                                                           17    3301
NP_001243468                                                           17    3301
NP_057475                                                              17    3301
NP_001278235                                                           17    3301
NP_001278237                                                           17    3301
NP_001265473                                                           17    4312
NP_000057                                                              17    4312
NP_001265472                                                           17    4312
XP_005271223                                                           17    4312
XP_006710936                                                           17    4312
NP_000528                                                              16    7355
NP_056190                                                              16    7355
NP_955749                                                              16    7355
NP_667338                                                              16    7355
NP_001159608                                                           16    7355
NP_001185625                                                           16    7355
NP_116186                                                              16    7355
NP_060903                                                              16    7355
NP_001140160                                                           16    7355
NP_004810                                                              16    7355
XP_005259343                                                           16    7355
XP_006713923                                                           16    7355
XP_006713922                                                           16    7355
NP_065176                                                              15    9605
NP_055928                                                              15    9605
NP_003819                                                              15    9605
NP_001231892                                                           15    9605
NP_001019554                                                           15    9605
NP_003480                                                              15    9605
NP_001104488                                                           15    9605
NP_660093                                                              15    9605
NP_055718                                                              15    9605
NP_892009                                                              15    9605
XP_006724919                                                           15    9605
XP_006724918                                                           15    9605
XP_005274825                                                           15    9605
XP_005274824                                                           15    9605
XP_005274823                                                           15    9605
XP_006724917                                                           15    9605
XP_005274822                                                           15    9605
XP_006724117                                                           15    9605
XP_005261123                                                           15    9605
XP_005261122                                                           15    9605
XP_005261120                                                           15    9605
XP_005256618                                                           15    9605
XP_005256617                                                           15    9605
XP_006719740                                                           15    9605
XP_006719739                                                           15    9605
XP_006719738                                                           15    9605
XP_005269272                                                           15    9605
XP_006718429                                                           15    9605
XP_006718428                                                           15    9605
XP_006718427                                                           15    9605
XP_006711671                                                           15    9605
XP_006711670                                                           15    9605
XP_005245629                                                           15    9605
>NP_000042
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SVRQNLKES 9
           SV QNLKES
Sbjct: 681 SVHQNLKES 689
>XP_005271621
          Length = 2708

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SVRQNLKES 9
           SV QNLKES
Sbjct: 333 SVHQNLKES 341
>XP_006718907
          Length = 3050

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SVRQNLKES 9
           SV QNLKES
Sbjct: 681 SVHQNLKES 689
>XP_006718906
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SVRQNLKES 9
           SV QNLKES
Sbjct: 681 SVHQNLKES 689
>XP_005271619
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SVRQNLKES 9
           SV QNLKES
Sbjct: 681 SVHQNLKES 689
>XP_005271618
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SVRQNLKES 9
           SV QNLKES
Sbjct: 681 SVHQNLKES 689
>NP_073619
          Length = 1183

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VRQNLKE 8
           +RQNLKE
Sbjct: 595 IRQNLKE 601
>XP_006719254
          Length = 810

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VRQNLKE 8
           +RQNLKE
Sbjct: 222 IRQNLKE 228
>XP_006719253
          Length = 1031

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VRQNLKE 8
           +RQNLKE
Sbjct: 443 IRQNLKE 449
>XP_006719252
          Length = 1031

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VRQNLKE 8
           +RQNLKE
Sbjct: 443 IRQNLKE 449
>XP_006719251
          Length = 1116

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VRQNLKE 8
           +RQNLKE
Sbjct: 528 IRQNLKE 534
>XP_006719250
          Length = 1141

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VRQNLKE 8
           +RQNLKE
Sbjct: 553 IRQNLKE 559
>NP_001278236
          Length = 138

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  SVRQNLKE 8
          SVRQNL E
Sbjct: 48 SVRQNLAE 55
>NP_001243469
          Length = 231

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  SVRQNLKE 8
          SVRQNL E
Sbjct: 48 SVRQNLAE 55
>NP_001243468
          Length = 232

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  SVRQNLKE 8
          SVRQNL E
Sbjct: 48 SVRQNLAE 55
>NP_057475
          Length = 178

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  SVRQNLKE 8
          SVRQNL E
Sbjct: 48 SVRQNLAE 55
>NP_001278235
          Length = 142

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  SVRQNLKE 8
          SVRQNL E
Sbjct: 48 SVRQNLAE 55
>NP_001278237
          Length = 99

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  SVRQNLKE 8
          SVRQNL E
Sbjct: 48 SVRQNLAE 55
>NP_001265473
          Length = 529

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SVRQNLKES 9
           +VRQN+K++
Sbjct: 422 TVRQNMKQA 430
>NP_000057
          Length = 591

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SVRQNLKES 9
           +VRQN+K++
Sbjct: 484 TVRQNMKQA 492
>NP_001265472
          Length = 539

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SVRQNLKES 9
           +VRQN+K++
Sbjct: 432 TVRQNMKQA 440
>XP_005271223
          Length = 628

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SVRQNLKES 9
           +VRQN+K++
Sbjct: 521 TVRQNMKQA 529
>XP_006710936
          Length = 630

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SVRQNLKES 9
           +VRQN+K++
Sbjct: 523 TVRQNMKQA 531
>NP_000528
          Length = 406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  SVRQNLKE 8
          S+R++LKE
Sbjct: 41 SIRESLKE 48
>NP_056190
          Length = 929

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VRQNLKES 9
          +RQNL+E+
Sbjct: 41 LRQNLRET 48
>NP_955749
          Length = 884

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VRQNLKES 9
          +RQNL+E+
Sbjct: 41 LRQNLRET 48
>NP_667338
          Length = 1308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SVRQNLKE 8
           SVRQ LK+
Sbjct: 805 SVRQRLKD 812
>NP_001159608
          Length = 1228

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SVRQNLKE 8
           SVRQ LK+
Sbjct: 725 SVRQRLKD 732
>NP_001185625
          Length = 373

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SVRQNLKE 8
           SVRQ +KE
Sbjct: 187 SVRQEVKE 194
>NP_116186
          Length = 373

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SVRQNLKE 8
           SVRQ +KE
Sbjct: 187 SVRQEVKE 194
>NP_060903
          Length = 1321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   QNLKES 9
           QNLKES
Sbjct: 482 QNLKES 487
>NP_001140160
          Length = 1321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   QNLKES 9
           QNLKES
Sbjct: 482 QNLKES 487
>NP_004810
          Length = 1274

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SVRQNLK 7
           SVR+NLK
Sbjct: 296 SVRKNLK 302
>XP_005259343
          Length = 1274

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SVRQNLK 7
           SVR+NLK
Sbjct: 296 SVRKNLK 302
>XP_006713923
          Length = 1228

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SVRQNLKE 8
           SVRQ LK+
Sbjct: 725 SVRQRLKD 732
>XP_006713922
          Length = 1262

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SVRQNLKE 8
           SVRQ LK+
Sbjct: 805 SVRQRLKD 812
>NP_065176
          Length = 1877

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRQNLKES 9
           +RQNL+E+
Sbjct: 268 LRQNLEET 275
>NP_055928
          Length = 2961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SVRQNL 6
           SVRQNL
Sbjct: 515 SVRQNL 520
>NP_003819
          Length = 665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VRQNLKE 8
           + QNLKE
Sbjct: 614 IHQNLKE 620
>NP_001231892
          Length = 2488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRQNLKES 9
           +RQNL+E+
Sbjct: 756 LRQNLEET 763
>NP_001019554
          Length = 2385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRQNLKES 9
           +RQNL+E+
Sbjct: 692 LRQNLEET 699
>NP_003480
          Length = 1158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VRQNLKE 8
           +RQ+LKE
Sbjct: 153 IRQSLKE 159
>NP_001104488
          Length = 2365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRQNLKES 9
           +RQNL+E+
Sbjct: 669 LRQNLEET 676
>NP_660093
          Length = 2429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRQNLKES 9
           +RQNL+E+
Sbjct: 733 LRQNLEET 740
>NP_055718
          Length = 2363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRQNLKES 9
           +RQNL+E+
Sbjct: 692 LRQNLEET 699
>NP_892009
          Length = 2432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRQNLKES 9
           +RQNL+E+
Sbjct: 733 LRQNLEET 740
>XP_006724919
          Length = 571

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VRQNLKE 8
           + QNLKE
Sbjct: 520 IHQNLKE 526
>XP_006724918
          Length = 665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VRQNLKE 8
           + QNLKE
Sbjct: 614 IHQNLKE 620
>XP_005274825
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VRQNLKE 8
           + QNLKE
Sbjct: 622 IHQNLKE 628
>XP_005274824
          Length = 682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VRQNLKE 8
           + QNLKE
Sbjct: 631 IHQNLKE 637
>XP_005274823
          Length = 682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VRQNLKE 8
           + QNLKE
Sbjct: 631 IHQNLKE 637
>XP_006724917
          Length = 690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VRQNLKE 8
           + QNLKE
Sbjct: 639 IHQNLKE 645
>XP_005274822
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VRQNLKE 8
           + QNLKE
Sbjct: 648 IHQNLKE 654
>XP_006724117
          Length = 1158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VRQNLKE 8
           +RQ+LKE
Sbjct: 153 IRQSLKE 159
>XP_005261123
          Length = 1158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VRQNLKE 8
           +RQ+LKE
Sbjct: 153 IRQSLKE 159
>XP_005261122
          Length = 1158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VRQNLKE 8
           +RQ+LKE
Sbjct: 153 IRQSLKE 159
>XP_005261120
          Length = 1158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VRQNLKE 8
           +RQ+LKE
Sbjct: 153 IRQSLKE 159
>XP_005256618
          Length = 2962

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SVRQNL 6
           SVRQNL
Sbjct: 515 SVRQNL 520
>XP_005256617
          Length = 2966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SVRQNL 6
           SVRQNL
Sbjct: 515 SVRQNL 520
>XP_006719740
          Length = 1863

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRQNLKES 9
           +RQNL+E+
Sbjct: 192 LRQNLEET 199
>XP_006719739
          Length = 2306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRQNLKES 9
           +RQNL+E+
Sbjct: 635 LRQNLEET 642
>XP_006719738
          Length = 2340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRQNLKES 9
           +RQNL+E+
Sbjct: 669 LRQNLEET 676
>XP_005269272
          Length = 2356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRQNLKES 9
           +RQNL+E+
Sbjct: 692 LRQNLEET 699
>XP_006718429
          Length = 2416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRQNLKES 9
           +RQNL+E+
Sbjct: 684 LRQNLEET 691
>XP_006718428
          Length = 2455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRQNLKES 9
           +RQNL+E+
Sbjct: 756 LRQNLEET 763
>XP_006718427
          Length = 2465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRQNLKES 9
           +RQNL+E+
Sbjct: 733 LRQNLEET 740
>XP_006711671
          Length = 2153

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRQNLKES 9
           +RQNL+E+
Sbjct: 555 LRQNLEET 562
>XP_006711670
          Length = 2161

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRQNLKES 9
           +RQNL+E+
Sbjct: 555 LRQNLEET 562
>XP_005245629
          Length = 2164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRQNLKES 9
           +RQNL+E+
Sbjct: 555 LRQNLEET 562
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.295    0.110    0.247 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 458,931
Number of extensions: 958
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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