Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              18    1482
NP_001087241                                                           18    1482
XP_005265799                                                           18    1482
XP_005265798                                                           18    1482
XP_005265797                                                           18    1482
NP_064716                                                              17    3301
NP_057006                                                              17    4312
NP_001123237                                                           17    4312
NP_940912                                                              17    4312
XP_006724887                                                           17    4312
NP_001747                                                              16    5631
NP_689758                                                              16    7355
XP_005262834                                                           16    7355
XP_006714175                                                           16    7355
XP_005262833                                                           16    7355
NP_002221                                                              15    9605
NP_068831                                                              15    9605
NP_065816                                                              15    9605
NP_694984                                                              15    9605
NP_056234                                                              15    9605
NP_002026                                                              15    9605
XP_005262172                                                           15    9605
XP_005262170                                                           15    9605
XP_005274542                                                           15    9605
XP_005266734                                                           15    9605
XP_006722496                                                           15    9605
XP_006721941                                                           15    9605
XP_006721940                                                           15    9605
XP_006721939                                                           15    9605
XP_006721938                                                           15    9605
XP_006721937                                                           15    9605
XP_006721936                                                           15    9605
XP_006721935                                                           15    9605
XP_006721934                                                           15    9605
XP_005257370                                                           15    9605
XP_006710573                                                           15    9605
XP_006710572                                                           15    9605
XP_006710571                                                           15    9605
XP_006710570                                                           15    9605
XP_006710569                                                           15    9605
XP_006710568                                                           15    9605
XP_006710567                                                           15    9605
XP_006710566                                                           15    9605
XP_005245859                                                           15    9605
NP_000929                                                              15    9605
>NP_000213
          Length = 976

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SVRINYVGS 9
           SVRIN VGS
Sbjct: 954 SVRINSVGS 962
>NP_001087241
          Length = 972

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SVRINYVGS 9
           SVRIN VGS
Sbjct: 950 SVRINSVGS 958
>XP_005265799
          Length = 973

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SVRINYVGS 9
           SVRIN VGS
Sbjct: 951 SVRINSVGS 959
>XP_005265798
          Length = 976

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SVRINYVGS 9
           SVRIN VGS
Sbjct: 954 SVRINSVGS 962
>XP_005265797
          Length = 977

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SVRINYVGS 9
           SVRIN VGS
Sbjct: 955 SVRINSVGS 963
>NP_064716
          Length = 578

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VRINYVG 8
           +RINY+G
Sbjct: 166 IRINYLG 172
>NP_057006
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   RINYVGS 9
           R+NY+G+
Sbjct: 119 RVNYIGT 125
>NP_001123237
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   RINYVGS 9
           R+NY+G+
Sbjct: 119 RVNYIGT 125
>NP_940912
          Length = 1313

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VRINYVG 8
           VR+NY+G
Sbjct: 477 VRLNYLG 483
>XP_006724887
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   RINYVGS 9
           R+NY+G+
Sbjct: 119 RVNYIGT 125
>NP_001747
          Length = 405

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VRINYVGS 9
           V++NYVG+
Sbjct: 253 VQMNYVGN 260
>NP_689758
          Length = 473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   RINYVG 8
           R+NY+G
Sbjct: 220 RLNYIG 225
>XP_005262834
          Length = 431

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   RINYVG 8
           R+NY+G
Sbjct: 178 RLNYIG 183
>XP_006714175
          Length = 432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   RINYVG 8
           R+NY+G
Sbjct: 179 RLNYIG 184
>XP_005262833
          Length = 472

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   RINYVG 8
           R+NY+G
Sbjct: 219 RLNYIG 224
>NP_002221
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SVRINY 6
           SVR+NY
Sbjct: 475 SVRLNY 480
>NP_068831
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SVRINY 6
           SVR+NY
Sbjct: 475 SVRLNY 480
>NP_065816
          Length = 5183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SVRINYVG 8
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
>NP_694984
          Length = 1802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRINYVGS 9
           +RI Y+GS
Sbjct: 342 IRIYYLGS 349
>NP_056234
          Length = 2828

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SVRINYVGS 9
            +V +NYVG+
Sbjct: 1528 NVFLNYVGN 1536
>NP_002026
          Length = 332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   INYVGS 9
           INY+GS
Sbjct: 144 INYLGS 149
>XP_005262172
          Length = 1631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRINYVGS 9
           +RI Y+GS
Sbjct: 171 IRIYYLGS 178
>XP_005262170
          Length = 1752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRINYVGS 9
           +RI Y+GS
Sbjct: 342 IRIYYLGS 349
>XP_005274542
          Length = 2853

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SVRINYVGS 9
            +V +NYVG+
Sbjct: 1553 NVFLNYVGN 1561
>XP_005266734
          Length = 298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   INYVGS 9
           INY+GS
Sbjct: 144 INYLGS 149
>XP_006722496
          Length = 303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   INYVGS 9
           INY+GS
Sbjct: 115 INYLGS 120
>XP_006721941
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SVRINY 6
           SVR+NY
Sbjct: 475 SVRLNY 480
>XP_006721940
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SVRINY 6
           SVR+NY
Sbjct: 475 SVRLNY 480
>XP_006721939
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SVRINY 6
           SVR+NY
Sbjct: 475 SVRLNY 480
>XP_006721938
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SVRINY 6
           SVR+NY
Sbjct: 475 SVRLNY 480
>XP_006721937
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SVRINY 6
           SVR+NY
Sbjct: 475 SVRLNY 480
>XP_006721936
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SVRINY 6
           SVR+NY
Sbjct: 475 SVRLNY 480
>XP_006721935
          Length = 762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SVRINY 6
           SVR+NY
Sbjct: 492 SVRLNY 497
>XP_006721934
          Length = 783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SVRINY 6
           SVR+NY
Sbjct: 513 SVRLNY 518
>XP_005257370
          Length = 783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SVRINY 6
           SVR+NY
Sbjct: 513 SVRLNY 518
>XP_006710573
          Length = 5177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SVRINYVG 8
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
>XP_006710572
          Length = 5188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SVRINYVG 8
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
>XP_006710571
          Length = 5194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SVRINYVG 8
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
>XP_006710570
          Length = 5195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SVRINYVG 8
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
>XP_006710569
          Length = 5212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SVRINYVG 8
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
>XP_006710568
          Length = 5221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SVRINYVG 8
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
>XP_006710567
          Length = 5222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SVRINYVG 8
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
>XP_006710566
          Length = 5222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SVRINYVG 8
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
>XP_005245859
          Length = 5223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SVRINYVG 8
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
>NP_000929
          Length = 1174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   SVRINYVGS 9
           +V +N++GS
Sbjct: 315 NVALNFIGS 323
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.134    0.359 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 424,846
Number of extensions: 485
Number of successful extensions: 45
Number of sequences better than 10000.0: 45
Number of HSP's gapped: 45
Number of HSP's successfully gapped: 45
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package