Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005350                                                              18    1482
NP_001275716                                                           17    2528
NP_001275715                                                           17    2528
NP_001275717                                                           17    2528
NP_001275718                                                           17    2528
NP_001076437                                                           17    2528
NP_001028723                                                           17    2528
XP_005256523                                                           17    2528
XP_005256520                                                           17    2528
XP_005256519                                                           17    2528
XP_006721515                                                           17    2528
XP_005256518                                                           17    2528
NP_001138356                                                           16    5631
NP_598003                                                              16    5631
NP_003103                                                              16    5631
NP_001243549                                                           16    5631
XP_006717832                                                           16    5631
XP_006717831                                                           16    5631
XP_005249886                                                           16    5631
XP_005249885                                                           16    5631
XP_005270560                                                           16    5631
NP_612478                                                              16    5631
NP_055287                                                              16    5631
NP_001243548                                                           16    5631
NP_005718                                                              16    7355
NP_003740                                                              16    7355
NP_937792                                                              16    7355
NP_061869                                                              15    9605
NP_001136112                                                           15    9605
NP_001139447                                                           15    9605
NP_003975                                                              15    9605
NP_055325                                                              15    9605
NP_149015                                                              15    9605
NP_055529                                                              15    9605
NP_060697                                                              15    9605
XP_006722228                                                           15    9605
XP_006722063                                                           15    9605
XP_006722061                                                           15    9605
XP_005257605                                                           15    9605
XP_005257604                                                           15    9605
XP_006722059                                                           15    9605
XP_005255783                                                           15    9605
XP_005255782                                                           15    9605
XP_006721054                                                           15    9605
XP_006721053                                                           15    9605
XP_006721052                                                           15    9605
XP_006715989                                                           15    9605
XP_006714316                                                           15    9605
>NP_005350
          Length = 552

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SVGGIASAI 9
           SVGGIA AI
Sbjct: 474 SVGGIAPAI 482
>NP_001275716
          Length = 462

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SVGGIASAI 9
           +VGG+ASA+
Sbjct: 364 AVGGLASAL 372
>NP_001275715
          Length = 483

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SVGGIASAI 9
           +VGG+ASA+
Sbjct: 356 AVGGLASAL 364
>NP_001275717
          Length = 389

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SVGGIASAI 9
           +VGG+ASA+
Sbjct: 311 AVGGLASAL 319
>NP_001275718
          Length = 388

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SVGGIASAI 9
           +VGG+ASA+
Sbjct: 261 AVGGLASAL 269
>NP_001076437
          Length = 507

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SVGGIASAI 9
           +VGG+ASA+
Sbjct: 409 AVGGLASAL 417
>NP_001028723
          Length = 457

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SVGGIASAI 9
           +VGG+ASA+
Sbjct: 359 AVGGLASAL 367
>XP_005256523
          Length = 438

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SVGGIASAI 9
           +VGG+ASA+
Sbjct: 311 AVGGLASAL 319
>XP_005256520
          Length = 487

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SVGGIASAI 9
           +VGG+ASA+
Sbjct: 409 AVGGLASAL 417
>XP_005256519
          Length = 491

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SVGGIASAI 9
           +VGG+ASA+
Sbjct: 364 AVGGLASAL 372
>XP_006721515
          Length = 503

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SVGGIASAI 9
           +VGG+ASA+
Sbjct: 376 AVGGLASAL 384
>XP_005256518
          Length = 536

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SVGGIASAI 9
           +VGG+ASA+
Sbjct: 409 AVGGLASAL 417
>NP_001138356
          Length = 376

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SVGGIASAI 9
           S+G IASAI
Sbjct: 248 SIGVIASAI 256
>NP_598003
          Length = 376

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SVGGIASAI 9
           S+G IASAI
Sbjct: 248 SIGVIASAI 256
>NP_003103
          Length = 784

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SVGGIASA 8
           +VGGIA+A
Sbjct: 581 AVGGIANA 588
>NP_001243549
          Length = 778

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SVGGIASA 8
           SVGGIA++
Sbjct: 288 SVGGIANS 295
>XP_006717832
          Length = 778

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SVGGIASA 8
           SVGGIA++
Sbjct: 288 SVGGIANS 295
>XP_006717831
          Length = 778

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SVGGIASA 8
           SVGGIA++
Sbjct: 288 SVGGIANS 295
>XP_005249886
          Length = 706

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SVGGIASA 8
           +VGGIA+A
Sbjct: 581 AVGGIANA 588
>XP_005249885
          Length = 767

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SVGGIASA 8
           +VGGIA+A
Sbjct: 564 AVGGIANA 571
>XP_005270560
          Length = 376

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SVGGIASAI 9
           S+G IASAI
Sbjct: 248 SIGVIASAI 256
>NP_612478
          Length = 778

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SVGGIASA 8
           SVGGIA++
Sbjct: 288 SVGGIANS 295
>NP_055287
          Length = 778

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SVGGIASA 8
           SVGGIA++
Sbjct: 288 SVGGIANS 295
>NP_001243548
          Length = 792

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SVGGIASA 8
           SVGGIA++
Sbjct: 288 SVGGIANS 295
>NP_005718
          Length = 241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SVGGIASAI 9
           +VGG+A+ I
Sbjct: 214 TVGGVAAGI 222
>NP_003740
          Length = 1338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SVGGIASAI 9
            S+GG+ SA+
Sbjct: 1289 SLGGLISAV 1297
>NP_937792
          Length = 197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SVGGIASAI 9
          ++ GIASA+
Sbjct: 85 TIAGIASAV 93
>NP_061869
          Length = 1690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SVGGIASAI 9
            ++GGIAS +
Sbjct: 1052 ALGGIASGL 1060
>NP_001136112
          Length = 1726

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SVGGIASAI 9
            ++GGIAS +
Sbjct: 1049 ALGGIASGL 1057
>NP_001139447
          Length = 641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SVGGIAS 7
           S+GGIA+
Sbjct: 279 SIGGIAT 285
>NP_003975
          Length = 592

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SVGGIAS 7
           S+GGIA+
Sbjct: 230 SIGGIAT 236
>NP_055325
          Length = 4935

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SVGGIAS 7
            S+GGI+S
Sbjct: 4226 SIGGISS 4232
>NP_149015
          Length = 5142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SVGGIAS 7
            S+GGI+S
Sbjct: 4226 SIGGISS 4232
>NP_055529
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VGGIAS 7
           VGGIAS
Sbjct: 569 VGGIAS 574
>NP_060697
          Length = 1052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SVGGIAS 7
           +VGG+AS
Sbjct: 393 AVGGVAS 399
>XP_006722228
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SVGGIAS 7
           S+GGIA+
Sbjct: 186 SIGGIAT 192
>XP_006722063
          Length = 1923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SVGGIASAI 9
            ++GGIAS +
Sbjct: 1285 ALGGIASGL 1293
>XP_006722061
          Length = 1913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SVGGIASAI 9
            ++GGIAS +
Sbjct: 1288 ALGGIASGL 1296
>XP_005257605
          Length = 1926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SVGGIASAI 9
            ++GGIAS +
Sbjct: 1288 ALGGIASGL 1296
>XP_005257604
          Length = 1962

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SVGGIASAI 9
            ++GGIAS +
Sbjct: 1285 ALGGIASGL 1293
>XP_006722059
          Length = 1965

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SVGGIASAI 9
            ++GGIAS +
Sbjct: 1288 ALGGIASGL 1296
>XP_005255783
          Length = 801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VGGIAS 7
           VGGIAS
Sbjct: 569 VGGIAS 574
>XP_005255782
          Length = 807

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VGGIAS 7
           VGGIAS
Sbjct: 569 VGGIAS 574
>XP_006721054
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VGGIAS 7
           VGGIAS
Sbjct: 569 VGGIAS 574
>XP_006721053
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VGGIAS 7
           VGGIAS
Sbjct: 569 VGGIAS 574
>XP_006721052
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VGGIAS 7
           VGGIAS
Sbjct: 569 VGGIAS 574
>XP_006715989
          Length = 5148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SVGGIAS 7
            S+GGI+S
Sbjct: 4226 SIGGISS 4232
>XP_006714316
          Length = 977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SVGGIAS 7
           +VGG+AS
Sbjct: 318 AVGGVAS 324
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.130    0.325 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 374,281
Number of extensions: 465
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package