Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_036462                                                              19     869
NP_001243397                                                           19     869
XP_005269721                                                           19     869
NP_001138498                                                           17    2528
NP_001166028                                                           17    3301
NP_005886                                                              17    3301
NP_001269105                                                           17    3301
NP_001269104                                                           17    3301
NP_001285                                                              17    3301
XP_005266224                                                           17    3301
XP_006719803                                                           17    3301
XP_005266222                                                           17    3301
XP_005266221                                                           17    3301
XP_006719802                                                           17    3301
XP_006719801                                                           17    3301
XP_006719800                                                           17    3301
XP_006719799                                                           17    3301
XP_005266219                                                           17    3301
XP_005274178                                                           17    3301
XP_005274177                                                           17    3301
XP_005274175                                                           17    3301
NP_065731                                                              17    3301
NP_001041683                                                           17    3301
NP_001575                                                              17    4312
XP_005253170                                                           17    4312
XP_006718367                                                           17    4312
XP_005253169                                                           17    4312
XP_005253168                                                           17    4312
XP_005253167                                                           17    4312
NP_112196                                                              16    5631
NP_001189352                                                           16    5631
NP_073577                                                              15    9605
NP_001106710                                                           15    9605
NP_006353                                                              15    9605
XP_006718483                                                           15    9605
XP_006718482                                                           15    9605
XP_006718481                                                           15    9605
XP_006715999                                                           15    9605
XP_006715998                                                           15    9605
XP_006715997                                                           15    9605
>NP_036462
          Length = 2073

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   STYISAST 8
           STYISAST
Sbjct: 417 STYISAST 424
>NP_001243397
          Length = 1890

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   STYISAST 8
           STYISAST
Sbjct: 417 STYISAST 424
>XP_005269721
          Length = 2073

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   STYISAST 8
           STYISAST
Sbjct: 417 STYISAST 424
>NP_001138498
          Length = 2299

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STYISASTR 9
           S Y++ASTR
Sbjct: 920 SAYVTASTR 928
>NP_001166028
          Length = 1134

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   STYISASTR 9
           S+Y SASTR
Sbjct: 318 SSYSSASTR 326
>NP_005886
          Length = 1498

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   STYISASTR 9
           S+Y SASTR
Sbjct: 318 SSYSSASTR 326
>NP_001269105
          Length = 567

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STYISASTR 9
           STYI +ST+
Sbjct: 359 STYIESSTK 367
>NP_001269104
          Length = 655

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STYISASTR 9
           STYI +ST+
Sbjct: 447 STYIESSTK 455
>NP_001285
          Length = 669

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STYISASTR 9
           STYI +ST+
Sbjct: 461 STYIESSTK 469
>XP_005266224
          Length = 1307

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   STYISASTR 9
           S+Y SASTR
Sbjct: 127 SSYSSASTR 135
>XP_006719803
          Length = 1407

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   STYISASTR 9
           S+Y SASTR
Sbjct: 227 SSYSSASTR 235
>XP_005266222
          Length = 1458

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   STYISASTR 9
           S+Y SASTR
Sbjct: 278 SSYSSASTR 286
>XP_005266221
          Length = 1458

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   STYISASTR 9
           S+Y SASTR
Sbjct: 278 SSYSSASTR 286
>XP_006719802
          Length = 1458

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   STYISASTR 9
           S+Y SASTR
Sbjct: 278 SSYSSASTR 286
>XP_006719801
          Length = 1498

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   STYISASTR 9
           S+Y SASTR
Sbjct: 318 SSYSSASTR 326
>XP_006719800
          Length = 1498

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   STYISASTR 9
           S+Y SASTR
Sbjct: 318 SSYSSASTR 326
>XP_006719799
          Length = 1498

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   STYISASTR 9
           S+Y SASTR
Sbjct: 318 SSYSSASTR 326
>XP_005266219
          Length = 1498

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   STYISASTR 9
           S+Y SASTR
Sbjct: 318 SSYSSASTR 326
>XP_005274178
          Length = 780

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TYISASTR 9
           +Y+SASTR
Sbjct: 457 SYLSASTR 464
>XP_005274177
          Length = 781

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TYISASTR 9
           +Y+SASTR
Sbjct: 457 SYLSASTR 464
>XP_005274175
          Length = 807

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TYISASTR 9
           +Y+SASTR
Sbjct: 457 SYLSASTR 464
>NP_065731
          Length = 808

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TYISASTR 9
           +Y+SASTR
Sbjct: 457 SYLSASTR 464
>NP_001041683
          Length = 791

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TYISASTR 9
           +Y+SASTR
Sbjct: 457 SYLSASTR 464
>NP_001575
          Length = 294

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   STYISAST 8
           +TYI+AST
Sbjct: 265 TTYINAST 272
>XP_005253170
          Length = 196

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   STYISAST 8
           +TYI+AST
Sbjct: 167 TTYINAST 174
>XP_006718367
          Length = 220

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   STYISAST 8
           +TYI+AST
Sbjct: 191 TTYINAST 198
>XP_005253169
          Length = 294

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   STYISAST 8
           +TYI+AST
Sbjct: 265 TTYINAST 272
>XP_005253168
          Length = 294

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   STYISAST 8
           +TYI+AST
Sbjct: 265 TTYINAST 272
>XP_005253167
          Length = 294

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   STYISAST 8
           +TYI+AST
Sbjct: 265 TTYINAST 272
>NP_112196
          Length = 733

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   STYISAST 8
           S+YI+AST
Sbjct: 214 SSYIAAST 221
>NP_001189352
          Length = 577

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  STYISAST 8
          S+YI+AST
Sbjct: 58 SSYIAAST 65
>NP_073577
          Length = 1198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    TYISAS 7
            TYISAS
Sbjct: 1171 TYISAS 1176
>NP_001106710
          Length = 1171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    TYISAS 7
            TYISAS
Sbjct: 1144 TYISAS 1149
>NP_006353
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   STYISA 6
           STYISA
Sbjct: 335 STYISA 340
>XP_006718483
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   STYISA 6
           STYISA
Sbjct: 335 STYISA 340
>XP_006718482
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   STYISA 6
           STYISA
Sbjct: 335 STYISA 340
>XP_006718481
          Length = 633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   STYISA 6
           STYISA
Sbjct: 335 STYISA 340
>XP_006715999
          Length = 1170

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    TYISAS 7
            TYISAS
Sbjct: 1143 TYISAS 1148
>XP_006715998
          Length = 1191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    TYISAS 7
            TYISAS
Sbjct: 1164 TYISAS 1169
>XP_006715997
          Length = 1197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    TYISAS 7
            TYISAS
Sbjct: 1170 TYISAS 1175
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.301    0.104    0.246 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 312,385
Number of extensions: 326
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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