Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000312                                                              18    1135
NP_149038                                                              17    3301
NP_060798                                                              16    5631
XP_005263769                                                           16    5631
XP_005263768                                                           16    5631
NP_620135                                                              16    7355
NP_001156807                                                           16    7355
NP_055833                                                              16    7355
NP_001186871                                                           16    7355
XP_006715464                                                           16    7355
XP_006715463                                                           16    7355
XP_006715462                                                           16    7355
XP_006715461                                                           16    7355
XP_006715460                                                           16    7355
XP_006715459                                                           16    7355
XP_006715458                                                           16    7355
XP_006715457                                                           16    7355
XP_006715456                                                           16    7355
NP_055840                                                              15    9605
NP_001243546                                                           15    9605
NP_006650                                                              15    9605
NP_003957                                                              15    9605
NP_001243275                                                           15    9605
NP_001137429                                                           15    9605
NP_110411                                                              15    9605
NP_757385                                                              15    9605
NP_115807                                                              15    9605
NP_722576                                                              15    9605
NP_001026872                                                           15    9605
NP_001243277                                                           15    9605
NP_001243276                                                           15    9605
XP_005262424                                                           15    9605
XP_006717659                                                           15    9605
XP_006715633                                                           15    9605
XP_006715632                                                           15    9605
XP_006714571                                                           15    9605
XP_006714570                                                           15    9605
XP_006714569                                                           15    9605
XP_006711931                                                           15    9605
XP_006711930                                                           15    9605
XP_006711929                                                           15    9605
XP_006711928                                                           15    9605
XP_006711927                                                           15    9605
XP_006711926                                                           15    9605
XP_006711925                                                           15    9605
>NP_000312
          Length = 928

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   STTSVNSTA 9
           STT VNSTA
Sbjct: 618 STTRVNSTA 626
>NP_149038
          Length = 512

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   STTSVNSTA 9
           STT+VNS A
Sbjct: 108 STTNVNSLA 116
>NP_060798
          Length = 1494

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TTSVNST 8
            TT+VNST
Sbjct: 1105 TTAVNST 1111
>XP_005263769
          Length = 1727

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TTSVNST 8
            TT+VNST
Sbjct: 1338 TTAVNST 1344
>XP_005263768
          Length = 1727

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TTSVNST 8
            TT+VNST
Sbjct: 1338 TTAVNST 1344
>NP_620135
          Length = 730

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   STTSVNS 7
           STTS+NS
Sbjct: 384 STTSLNS 390
>NP_001156807
          Length = 730

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   STTSVNS 7
           STTS+NS
Sbjct: 384 STTSLNS 390
>NP_055833
          Length = 2465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STTSVNS 7
            STTSVN+
Sbjct: 1404 STTSVNN 1410
>NP_001186871
          Length = 2476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STTSVNS 7
            STTSVN+
Sbjct: 1395 STTSVNN 1401
>XP_006715464
          Length = 2027

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STTSVNS 7
            STTSVN+
Sbjct: 1404 STTSVNN 1410
>XP_006715463
          Length = 2434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STTSVNS 7
            STTSVN+
Sbjct: 1404 STTSVNN 1410
>XP_006715462
          Length = 2452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STTSVNS 7
            STTSVN+
Sbjct: 1371 STTSVNN 1377
>XP_006715461
          Length = 2456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STTSVNS 7
            STTSVN+
Sbjct: 1395 STTSVNN 1401
>XP_006715460
          Length = 2465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STTSVNS 7
            STTSVN+
Sbjct: 1404 STTSVNN 1410
>XP_006715459
          Length = 2475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STTSVNS 7
            STTSVN+
Sbjct: 1394 STTSVNN 1400
>XP_006715458
          Length = 2476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STTSVNS 7
            STTSVN+
Sbjct: 1395 STTSVNN 1401
>XP_006715457
          Length = 2485

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STTSVNS 7
            STTSVN+
Sbjct: 1404 STTSVNN 1410
>XP_006715456
          Length = 2485

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STTSVNS 7
            STTSVN+
Sbjct: 1404 STTSVNN 1410
>NP_055840
          Length = 1184

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TTSVNS 7
           TTSVNS
Sbjct: 412 TTSVNS 417
>NP_001243546
          Length = 930

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   STTSVNSTA 9
           STTS+N  A
Sbjct: 116 STTSINVPA 124
>NP_006650
          Length = 902

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   STTSVNSTA 9
           STTS+N  A
Sbjct: 116 STTSINVPA 124
>NP_003957
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTSVNSTA 9
           TT+VNS A
Sbjct: 308 TTNVNSIA 315
>NP_001243275
          Length = 1151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTSVNSTA 9
           TT+VNS A
Sbjct: 376 TTNVNSIA 383
>NP_001137429
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  STTSVNSTA 9
          S+ +VNSTA
Sbjct: 57 SSLTVNSTA 65
>NP_110411
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  STTSVNSTA 9
          S+ +VNSTA
Sbjct: 57 SSLTVNSTA 65
>NP_757385
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSVNST 8
           TSVNST
Sbjct: 538 TSVNST 543
>NP_115807
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSVNST 8
           TSVNST
Sbjct: 537 TSVNST 542
>NP_722576
          Length = 3080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    TTSVNS 7
            TTSVNS
Sbjct: 1224 TTSVNS 1229
>NP_001026872
          Length = 1151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTSVNSTA 9
           TT+VNS A
Sbjct: 376 TTNVNSIA 383
>NP_001243277
          Length = 1057

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTSVNSTA 9
           TT+VNS A
Sbjct: 318 TTNVNSIA 325
>NP_001243276
          Length = 1205

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTSVNSTA 9
           TT+VNS A
Sbjct: 430 TTNVNSIA 437
>XP_005262424
          Length = 2875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    TTSVNS 7
            TTSVNS
Sbjct: 1019 TTSVNS 1024
>XP_006717659
          Length = 902

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   STTSVNSTA 9
           STTS+N  A
Sbjct: 116 STTSINVPA 124
>XP_006715633
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  STTSVNSTA 9
          S+ +VNSTA
Sbjct: 57 SSLTVNSTA 65
>XP_006715632
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  STTSVNSTA 9
          S+ +VNSTA
Sbjct: 57 SSLTVNSTA 65
>XP_006714571
          Length = 917

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTSVNSTA 9
           TT+VNS A
Sbjct: 151 TTNVNSIA 158
>XP_006714570
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTSVNSTA 9
           TT+VNS A
Sbjct: 308 TTNVNSIA 315
>XP_006714569
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTSVNSTA 9
           TT+VNS A
Sbjct: 308 TTNVNSIA 315
>XP_006711931
          Length = 1162

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TTSVNS 7
           TTSVNS
Sbjct: 412 TTSVNS 417
>XP_006711930
          Length = 1186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TTSVNS 7
           TTSVNS
Sbjct: 412 TTSVNS 417
>XP_006711929
          Length = 1186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TTSVNS 7
           TTSVNS
Sbjct: 412 TTSVNS 417
>XP_006711928
          Length = 1188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TTSVNS 7
           TTSVNS
Sbjct: 412 TTSVNS 417
>XP_006711927
          Length = 1207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TTSVNS 7
           TTSVNS
Sbjct: 412 TTSVNS 417
>XP_006711926
          Length = 1207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TTSVNS 7
           TTSVNS
Sbjct: 412 TTSVNS 417
>XP_006711925
          Length = 1209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TTSVNS 7
           TTSVNS
Sbjct: 412 TTSVNS 417
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.270   0.0797    0.168 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 292,659
Number of extensions: 381
Number of successful extensions: 45
Number of sequences better than 10000.0: 45
Number of HSP's gapped: 45
Number of HSP's successfully gapped: 45
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.5 bits)
S2: 28 (15.4 bits)

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