Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004295                                                              18    1135
NP_031377                                                              17    2528
XP_005262913                                                           17    2528
NP_006717                                                              17    3301
NP_001186211                                                           17    3301
XP_005263433                                                           17    3301
XP_005263432                                                           17    3301
XP_005263431                                                           17    3301
XP_006714492                                                           17    3301
XP_005263430                                                           17    3301
XP_005263429                                                           17    3301
NP_001367                                                              16    7355
NP_001139317                                                           16    7355
NP_598334                                                              16    7355
NP_002932                                                              16    7355
XP_006713341                                                           16    7355
XP_006713340                                                           16    7355
XP_006713339                                                           16    7355
NP_060698                                                              16    7355
NP_002778                                                              15    9605
NP_054742                                                              15    9605
NP_002883                                                              15    9605
NP_075377                                                              15    9605
NP_075376                                                              15    9605
XP_006722374                                                           15    9605
XP_006722373                                                           15    9605
XP_006722370                                                           15    9605
XP_006722365                                                           15    9605
XP_005268022                                                           15    9605
XP_005268021                                                           15    9605
NP_001004686                                                           15    9605
>NP_004295
          Length = 1620

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   STTQLIQKV 9
           ST QLIQKV
Sbjct: 785 STNQLIQKV 793
>NP_031377
          Length = 1228

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   STTQLIQKV 9
           ST Q+IQKV
Sbjct: 422 STRQIIQKV 430
>XP_005262913
          Length = 1193

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   STTQLIQKV 9
           ST Q+IQKV
Sbjct: 387 STRQIIQKV 395
>NP_006717
          Length = 2863

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    STTQLIQKV 9
            + TQLIQK+
Sbjct: 1949 TATQLIQKI 1957
>NP_001186211
          Length = 2851

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    STTQLIQKV 9
            + TQLIQK+
Sbjct: 1949 TATQLIQKI 1957
>XP_005263433
          Length = 2832

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    STTQLIQKV 9
            + TQLIQK+
Sbjct: 1913 TATQLIQKI 1921
>XP_005263432
          Length = 2852

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    STTQLIQKV 9
            + TQLIQK+
Sbjct: 1949 TATQLIQKI 1957
>XP_005263431
          Length = 2857

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    STTQLIQKV 9
            + TQLIQK+
Sbjct: 1949 TATQLIQKI 1957
>XP_006714492
          Length = 2867

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    STTQLIQKV 9
            + TQLIQK+
Sbjct: 1949 TATQLIQKI 1957
>XP_005263430
          Length = 2868

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    STTQLIQKV 9
            + TQLIQK+
Sbjct: 1949 TATQLIQKI 1957
>XP_005263429
          Length = 2868

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    STTQLIQKV 9
            + TQLIQK+
Sbjct: 1949 TATQLIQKI 1957
>NP_001367
          Length = 4646

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TQLIQKV 9
           TQLIQ+V
Sbjct: 606 TQLIQRV 612
>NP_001139317
          Length = 1551

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   STTQLIQ 7
           +TTQLIQ
Sbjct: 974 ATTQLIQ 980
>NP_598334
          Length = 1606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STTQLIQ 7
            +TTQLIQ
Sbjct: 1029 ATTQLIQ 1035
>NP_002932
          Length = 1651

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STTQLIQ 7
            +TTQLIQ
Sbjct: 1074 ATTQLIQ 1080
>XP_006713341
          Length = 1600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STTQLIQ 7
            +TTQLIQ
Sbjct: 1023 ATTQLIQ 1029
>XP_006713340
          Length = 1615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STTQLIQ 7
            +TTQLIQ
Sbjct: 1038 ATTQLIQ 1044
>XP_006713339
          Length = 1616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STTQLIQ 7
            +TTQLIQ
Sbjct: 1039 ATTQLIQ 1045
>NP_060698
          Length = 702

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  STTQLIQKV 9
          S  QL+QKV
Sbjct: 3  SRNQLVQKV 11
>NP_002778
          Length = 234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TTQLIQKV 9
           T QL+Q+V
Sbjct: 107 TAQLVQRV 114
>NP_054742
          Length = 494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STTQLIQKV 9
           ST+QL QK+
Sbjct: 114 STSQLSQKL 122
>NP_002883
          Length = 1257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  STTQLIQ 7
          +TTQL+Q
Sbjct: 46 NTTQLVQ 52
>NP_075377
          Length = 1188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  STTQLIQ 7
          +TTQL+Q
Sbjct: 46 NTTQLVQ 52
>NP_075376
          Length = 1203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  STTQLIQ 7
          +TTQL+Q
Sbjct: 46 NTTQLVQ 52
>XP_006722374
          Length = 944

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STTQLIQKV 9
           STT+ +QK+
Sbjct: 782 STTEALQKM 790
>XP_006722373
          Length = 948

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STTQLIQKV 9
           STT+ +QK+
Sbjct: 786 STTEALQKM 794
>XP_006722370
          Length = 956

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STTQLIQKV 9
           STT+ +QK+
Sbjct: 794 STTEALQKM 802
>XP_006722365
          Length = 981

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STTQLIQKV 9
           STT+ +QK+
Sbjct: 819 STTEALQKM 827
>XP_005268022
          Length = 1208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  STTQLIQ 7
          +TTQL+Q
Sbjct: 46 NTTQLVQ 52
>XP_005268021
          Length = 1277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  STTQLIQ 7
          +TTQL+Q
Sbjct: 46 NTTQLVQ 52
>NP_001004686
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TQLIQKV 9
           TQ+IQK+
Sbjct: 301 TQVIQKI 307
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.116    0.262 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 356,498
Number of extensions: 506
Number of successful extensions: 31
Number of sequences better than 10000.0: 31
Number of HSP's gapped: 31
Number of HSP's successfully gapped: 31
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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