Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              18    1482
XP_006713721                                                           18    1482
NP_001139280                                                           17    2528
NP_000623                                                              17    2528
NP_038477                                                              16    5631
XP_006719271                                                           16    5631
XP_005268661                                                           16    5631
XP_005268660                                                           16    5631
XP_005268659                                                           16    5631
XP_005268657                                                           16    5631
XP_006719270                                                           16    5631
XP_005268656                                                           16    5631
XP_005268654                                                           16    5631
XP_005268653                                                           16    5631
NP_001026                                                              16    7355
NP_056069                                                              16    7355
NP_056364                                                              16    7355
NP_056145                                                              16    7355
NP_150231                                                              16    7355
NP_150230                                                              16    7355
NP_116162                                                              16    7355
NP_001647                                                              16    7355
NP_001241661                                                           16    7355
NP_001138940                                                           16    7355
XP_005267570                                                           16    7355
XP_006720171                                                           16    7355
XP_005267569                                                           16    7355
XP_005267568                                                           16    7355
XP_006720170                                                           16    7355
XP_006720169                                                           16    7355
XP_006716380                                                           16    7355
XP_006716379                                                           16    7355
XP_005273516                                                           16    7355
XP_005273515                                                           16    7355
XP_005248554                                                           16    7355
XP_006713856                                                           16    7355
XP_005269424                                                           16    7355
XP_006713855                                                           16    7355
XP_005269422                                                           16    7355
XP_006713854                                                           16    7355
XP_005269420                                                           16    7355
XP_005269419                                                           16    7355
XP_006711873                                                           16    7355
XP_006711871                                                           16    7355
XP_006711870                                                           16    7355
XP_006711869                                                           16    7355
XP_006711868                                                           16    7355
XP_006711867                                                           16    7355
XP_006711866                                                           16    7355
XP_006711865                                                           16    7355
NP_689914                                                              15    9605
NP_982271                                                              15    9605
NP_001153774                                                           15    9605
NP_003886                                                              15    9605
NP_001191957                                                           15    9605
NP_001153778                                                           15    9605
NP_059136                                                              15    9605
XP_006724601                                                           15    9605
XP_005261137                                                           15    9605
XP_006724126                                                           15    9605
XP_006724125                                                           15    9605
XP_006724124                                                           15    9605
XP_005261133                                                           15    9605
XP_006724123                                                           15    9605
XP_006724122                                                           15    9605
XP_006724121                                                           15    9605
XP_005269084                                                           15    9605
XP_005269083                                                           15    9605
>NP_006209
          Length = 1068

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   STRDRLSEI 9
           STRD LSEI
Sbjct: 535 STRDPLSEI 543
>XP_006713721
          Length = 1068

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   STRDRLSEI 9
           STRD LSEI
Sbjct: 535 STRDPLSEI 543
>NP_001139280
          Length = 1153

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   STRDRLSE 8
           STRDRL E
Sbjct: 661 STRDRLRE 668
>NP_000623
          Length = 1152

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   STRDRLSE 8
           STRDRL E
Sbjct: 660 STRDRLRE 667
>NP_038477
          Length = 1905

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TRDRLSEI 9
           TRD +SEI
Sbjct: 933 TRDNVSEI 940
>XP_006719271
          Length = 1555

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TRDRLSEI 9
           TRD +SEI
Sbjct: 952 TRDNVSEI 959
>XP_005268661
          Length = 1657

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TRDRLSEI 9
           TRD +SEI
Sbjct: 685 TRDNVSEI 692
>XP_005268660
          Length = 1875

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TRDRLSEI 9
           TRD +SEI
Sbjct: 903 TRDNVSEI 910
>XP_005268659
          Length = 1894

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TRDRLSEI 9
           TRD +SEI
Sbjct: 922 TRDNVSEI 929
>XP_005268657
          Length = 1903

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TRDRLSEI 9
           TRD +SEI
Sbjct: 931 TRDNVSEI 938
>XP_006719270
          Length = 1903

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TRDRLSEI 9
           TRD +SEI
Sbjct: 931 TRDNVSEI 938
>XP_005268656
          Length = 1903

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TRDRLSEI 9
           TRD +SEI
Sbjct: 931 TRDNVSEI 938
>XP_005268654
          Length = 1923

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TRDRLSEI 9
           TRD +SEI
Sbjct: 952 TRDNVSEI 959
>XP_005268653
          Length = 1924

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TRDRLSEI 9
           TRD +SEI
Sbjct: 952 TRDNVSEI 959
>NP_001026
          Length = 4967

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RDRLSEI 9
            RDR+SE+
Sbjct: 4663 RDRISEL 4669
>NP_056069
          Length = 1826

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   STRDRLSEI 9
           S RDR SE+
Sbjct: 977 SLRDRWSEV 985
>NP_056364
          Length = 1163

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   STRDRL 6
           STRDRL
Sbjct: 654 STRDRL 659
>NP_056145
          Length = 1117

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STRDRLSE 8
           STR+RL E
Sbjct: 121 STRERLRE 128
>NP_150231
          Length = 546

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STRDRLSE 8
           S RDR+SE
Sbjct: 482 SHRDRISE 489
>NP_150230
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STRDRLSE 8
           S RDR+SE
Sbjct: 482 SHRDRISE 489
>NP_116162
          Length = 712

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  TRDRLSEI 9
          +R+RLSEI
Sbjct: 90 SRNRLSEI 97
>NP_001647
          Length = 574

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STRDRLSE 8
           S RDR+SE
Sbjct: 482 SHRDRISE 489
>NP_001241661
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STRDRLSE 8
           STR+RL E
Sbjct: 121 STRERLRE 128
>NP_001138940
          Length = 1117

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STRDRLSE 8
           STR+RL E
Sbjct: 121 STRERLRE 128
>XP_005267570
          Length = 1219

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   STRDRL 6
           STRDRL
Sbjct: 710 STRDRL 715
>XP_006720171
          Length = 1240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   STRDRL 6
           STRDRL
Sbjct: 731 STRDRL 736
>XP_005267569
          Length = 1340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   STRDRL 6
           STRDRL
Sbjct: 831 STRDRL 836
>XP_005267568
          Length = 1340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   STRDRL 6
           STRDRL
Sbjct: 831 STRDRL 836
>XP_006720170
          Length = 1354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   STRDRL 6
           STRDRL
Sbjct: 845 STRDRL 850
>XP_006720169
          Length = 1361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   STRDRL 6
           STRDRL
Sbjct: 852 STRDRL 857
>XP_006716380
          Length = 1762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   STRDRLSEI 9
           S RDR SE+
Sbjct: 913 SLRDRWSEV 921
>XP_006716379
          Length = 1762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   STRDRLSEI 9
           S RDR SE+
Sbjct: 913 SLRDRWSEV 921
>XP_005273516
          Length = 1762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   STRDRLSEI 9
           S RDR SE+
Sbjct: 913 SLRDRWSEV 921
>XP_005273515
          Length = 1805

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   STRDRLSEI 9
           S RDR SE+
Sbjct: 977 SLRDRWSEV 985
>XP_005248554
          Length = 398

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STRDRLSE 8
           S RDR+SE
Sbjct: 306 SHRDRISE 313
>XP_006713856
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  TRDRLSEI 9
          +R+RLSEI
Sbjct: 90 SRNRLSEI 97
>XP_005269424
          Length = 743

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  TRDRLSEI 9
          +R+RLSEI
Sbjct: 90 SRNRLSEI 97
>XP_006713855
          Length = 753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  TRDRLSEI 9
          +R+RLSEI
Sbjct: 90 SRNRLSEI 97
>XP_005269422
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  TRDRLSEI 9
          +R+RLSEI
Sbjct: 90 SRNRLSEI 97
>XP_006713854
          Length = 777

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  TRDRLSEI 9
          +R+RLSEI
Sbjct: 90 SRNRLSEI 97
>XP_005269420
          Length = 779

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  TRDRLSEI 9
          +R+RLSEI
Sbjct: 90 SRNRLSEI 97
>XP_005269419
          Length = 803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  TRDRLSEI 9
          +R+RLSEI
Sbjct: 90 SRNRLSEI 97
>XP_006711873
          Length = 4954

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RDRLSEI 9
            RDR+SE+
Sbjct: 4650 RDRISEL 4656
>XP_006711871
          Length = 4906

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RDRLSEI 9
            RDR+SE+
Sbjct: 4602 RDRISEL 4608
>XP_006711870
          Length = 4965

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RDRLSEI 9
            RDR+SE+
Sbjct: 4661 RDRISEL 4667
>XP_006711869
          Length = 4973

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RDRLSEI 9
            RDR+SE+
Sbjct: 4669 RDRISEL 4675
>XP_006711868
          Length = 4975

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RDRLSEI 9
            RDR+SE+
Sbjct: 4671 RDRISEL 4677
>XP_006711867
          Length = 4977

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RDRLSEI 9
            RDR+SE+
Sbjct: 4673 RDRISEL 4679
>XP_006711866
          Length = 4984

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RDRLSEI 9
            RDR+SE+
Sbjct: 4680 RDRISEL 4686
>XP_006711865
          Length = 4985

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RDRLSEI 9
            RDR+SE+
Sbjct: 4681 RDRISEL 4687
>NP_689914
          Length = 5058

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    TRDRLSEI 9
            TRD +SE+
Sbjct: 1935 TRDSISEL 1942
>NP_982271
          Length = 1350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   STRDRLSEI 9
           S  DR+SE+
Sbjct: 150 SDEDRISEV 158
>NP_001153774
          Length = 1295

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   STRDRLSEI 9
           S  DR+SE+
Sbjct: 111 SDEDRISEV 119
>NP_003886
          Length = 1612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   STRDRLSEI 9
           S  DR+SE+
Sbjct: 150 SDEDRISEV 158
>NP_001191957
          Length = 679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DRLSEI 9
           DRLSEI
Sbjct: 645 DRLSEI 650
>NP_001153778
          Length = 1526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   STRDRLSEI 9
           S  DR+SE+
Sbjct: 111 SDEDRISEV 119
>NP_059136
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DRLSEI 9
           DRLSEI
Sbjct: 680 DRLSEI 685
>XP_006724601
          Length = 1020

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DRLSEI 9
           DRLSEI
Sbjct: 786 DRLSEI 791
>XP_005261137
          Length = 1264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   STRDRLSEI 9
           S  DR+SE+
Sbjct: 111 SDEDRISEV 119
>XP_006724126
          Length = 1313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   STRDRLSEI 9
           S  DR+SE+
Sbjct: 111 SDEDRISEV 119
>XP_006724125
          Length = 1313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   STRDRLSEI 9
           S  DR+SE+
Sbjct: 111 SDEDRISEV 119
>XP_006724124
          Length = 1534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   STRDRLSEI 9
           S  DR+SE+
Sbjct: 111 SDEDRISEV 119
>XP_005261133
          Length = 1557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   STRDRLSEI 9
           S  DR+SE+
Sbjct: 111 SDEDRISEV 119
>XP_006724123
          Length = 1560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   STRDRLSEI 9
           S  DR+SE+
Sbjct: 111 SDEDRISEV 119
>XP_006724122
          Length = 1568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   STRDRLSEI 9
           S  DR+SE+
Sbjct: 111 SDEDRISEV 119
>XP_006724121
          Length = 1576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   STRDRLSEI 9
           S  DR+SE+
Sbjct: 111 SDEDRISEV 119
>XP_005269084
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DRLSEI 9
           DRLSEI
Sbjct: 588 DRLSEI 593
>XP_005269083
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DRLSEI 9
           DRLSEI
Sbjct: 690 DRLSEI 695
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.125    0.299 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 390,670
Number of extensions: 548
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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