Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              20     299
XP_006717989                                                           20     299
NP_055811                                                              18    1135
XP_005247296                                                           18    1135
XP_006713604                                                           18    1135
XP_005247295                                                           18    1135
NP_001124432                                                           18    1135
NP_001265273                                                           18    1935
NP_001094                                                              18    1935
NP_001265272                                                           18    1935
NP_001276324                                                           17    2528
NP_003313                                                              17    2528
NP_813977                                                              17    2528
NP_003311                                                              17    2528
XP_006718366                                                           17    2528
XP_005253166                                                           17    2528
NP_001003712                                                           17    4312
NP_065892                                                              17    4312
XP_005268680                                                           17    4312
XP_006719287                                                           17    4312
XP_005268679                                                           17    4312
XP_005268678                                                           17    4312
XP_006719286                                                           17    4312
XP_006719285                                                           17    4312
NP_004915                                                              16    5631
NP_001138537                                                           16    5631
NP_001093                                                              16    5631
NP_001123477                                                           16    5631
NP_001123476                                                           16    5631
NP_006548                                                              16    5631
NP_870987                                                              16    5631
NP_001124337                                                           16    5631
XP_005259339                                                           16    5631
XP_005259338                                                           16    5631
XP_006723469                                                           16    5631
XP_005251411                                                           16    5631
XP_005251409                                                           16    5631
XP_005251408                                                           16    5631
XP_006716780                                                           16    5631
NP_001161710                                                           16    7355
NP_001161709                                                           16    7355
NP_001161708                                                           16    7355
NP_009298                                                              16    7355
NP_004046                                                              16    7355
NP_005149                                                              16    7355
NP_001161711                                                           16    7355
XP_005245145                                                           16    7355
NP_001129472                                                           16    7355
NP_000375                                                              15    9605
NP_001245300                                                           15    9605
NP_001095                                                              15    9605
NP_001001331                                                           15    9605
NP_003310                                                              15    9605
NP_597676                                                              15    9605
NP_001243779                                                           15    9605
NP_596869                                                              15    9605
XP_006718528                                                           15    9605
XP_006713243                                                           15    9605
XP_006713242                                                           15    9605
XP_006713239                                                           15    9605
XP_005265236                                                           15    9605
XP_006713238                                                           15    9605
XP_005246888                                                           15    9605
XP_006712788                                                           15    9605
XP_006712787                                                           15    9605
XP_006712786                                                           15    9605
NP_001254479                                                           15    9605
NP_597681                                                              15    9605
>NP_000305
          Length = 403

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TRDKKGVT 9
           TRDKKGVT
Sbjct: 160 TRDKKGVT 167
>XP_006717989
          Length = 388

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TRDKKGVT 9
           TRDKKGVT
Sbjct: 145 TRDKKGVT 152
>NP_055811
          Length = 1655

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    RDKKGVT 9
            RDKKGVT
Sbjct: 1486 RDKKGVT 1492
>XP_005247296
          Length = 1673

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    RDKKGVT 9
            RDKKGVT
Sbjct: 1504 RDKKGVT 1510
>XP_006713604
          Length = 1685

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    RDKKGVT 9
            RDKKGVT
Sbjct: 1516 RDKKGVT 1522
>XP_005247295
          Length = 1705

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    RDKKGVT 9
            RDKKGVT
Sbjct: 1536 RDKKGVT 1542
>NP_001124432
          Length = 1693

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    RDKKGVT 9
            RDKKGVT
Sbjct: 1524 RDKKGVT 1530
>NP_001265273
          Length = 686

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TRDKKGVT 9
           TRD KG+T
Sbjct: 536 TRDAKGIT 543
>NP_001094
          Length = 894

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TRDKKGVT 9
           TRD KG+T
Sbjct: 744 TRDAKGIT 751
>NP_001265272
          Length = 894

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TRDKKGVT 9
           TRD KG+T
Sbjct: 744 TRDAKGIT 751
>NP_001276324
          Length = 489

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TRDKKGV 8
           TRDKKG+
Sbjct: 257 TRDKKGM 263
>NP_003313
          Length = 542

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TRDKKGV 8
           TRDKKG+
Sbjct: 310 TRDKKGM 316
>NP_813977
          Length = 506

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TRDKKGV 8
           TRDKKG+
Sbjct: 270 TRDKKGM 276
>NP_003311
          Length = 561

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TRDKKGV 8
           TRDKKG+
Sbjct: 325 TRDKKGM 331
>XP_006718366
          Length = 451

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TRDKKGV 8
           TRDKKG+
Sbjct: 312 TRDKKGM 318
>XP_005253166
          Length = 548

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TRDKKGV 8
           TRDKKG+
Sbjct: 312 TRDKKGM 318
>NP_001003712
          Length = 847

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STRDKKGV 8
           STR KKG+
Sbjct: 776 STRRKKGI 783
>NP_065892
          Length = 889

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STRDKKGV 8
           STR KKG+
Sbjct: 818 STRRKKGI 825
>XP_005268680
          Length = 847

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STRDKKGV 8
           STR KKG+
Sbjct: 776 STRRKKGI 783
>XP_006719287
          Length = 847

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STRDKKGV 8
           STR KKG+
Sbjct: 776 STRRKKGI 783
>XP_005268679
          Length = 886

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STRDKKGV 8
           STR KKG+
Sbjct: 815 STRRKKGI 822
>XP_005268678
          Length = 889

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STRDKKGV 8
           STR KKG+
Sbjct: 818 STRRKKGI 825
>XP_006719286
          Length = 909

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STRDKKGV 8
           STR KKG+
Sbjct: 838 STRRKKGI 845
>XP_006719285
          Length = 912

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STRDKKGV 8
           STR KKG+
Sbjct: 841 STRRKKGI 848
>NP_004915
          Length = 911

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TRDKKGVT 9
           TRD KG++
Sbjct: 756 TRDAKGIS 763
>NP_001138537
          Length = 900

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STRDKKGV 8
           STRD+K +
Sbjct: 752 STRDRKAI 759
>NP_001093
          Length = 892

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TRDKKGVT 9
           TRD KG++
Sbjct: 737 TRDAKGIS 744
>NP_001123477
          Length = 887

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TRDKKGVT 9
           TRD KG++
Sbjct: 737 TRDAKGIS 744
>NP_001123476
          Length = 914

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TRDKKGVT 9
           TRD KG++
Sbjct: 737 TRDAKGIS 744
>NP_006548
          Length = 226

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STRDKKGVT 9
           +T DKKG++
Sbjct: 173 ATEDKKGLS 181
>NP_870987
          Length = 561

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STRDKKGVT 9
           +T DKKG++
Sbjct: 173 ATEDKKGLS 181
>NP_001124337
          Length = 226

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STRDKKGVT 9
           +T DKKG++
Sbjct: 173 ATEDKKGLS 181
>XP_005259339
          Length = 906

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TRDKKGVT 9
           TRD KG++
Sbjct: 756 TRDAKGIS 763
>XP_005259338
          Length = 906

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TRDKKGVT 9
           TRD KG++
Sbjct: 756 TRDAKGIS 763
>XP_006723469
          Length = 911

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TRDKKGVT 9
           TRD KG++
Sbjct: 756 TRDAKGIS 763
>XP_005251411
          Length = 226

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STRDKKGVT 9
           +T DKKG++
Sbjct: 173 ATEDKKGLS 181
>XP_005251409
          Length = 561

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STRDKKGVT 9
           +T DKKG++
Sbjct: 173 ATEDKKGLS 181
>XP_005251408
          Length = 561

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STRDKKGVT 9
           +T DKKG++
Sbjct: 173 ATEDKKGLS 181
>XP_006716780
          Length = 561

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STRDKKGVT 9
           +T DKKG++
Sbjct: 173 ATEDKKGLS 181
>NP_001161710
          Length = 1058

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TRDKKG 7
           TRD+KG
Sbjct: 624 TRDRKG 629
>NP_001161709
          Length = 1079

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TRDKKG 7
           TRD+KG
Sbjct: 645 TRDRKG 650
>NP_001161708
          Length = 1161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TRDKKG 7
           TRD+KG
Sbjct: 624 TRDRKG 629
>NP_009298
          Length = 1182

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TRDKKG 7
           TRD+KG
Sbjct: 645 TRDRKG 650
>NP_004046
          Length = 640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   STRDKKGVT 9
           S R+K GVT
Sbjct: 308 SEREKMGVT 316
>NP_005149
          Length = 1167

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TRDKKG 7
           TRD+KG
Sbjct: 630 TRDRKG 635
>NP_001161711
          Length = 1043

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TRDKKG 7
           TRD+KG
Sbjct: 609 TRDRKG 614
>XP_005245145
          Length = 1146

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TRDKKG 7
           TRD+KG
Sbjct: 609 TRDRKG 614
>NP_001129472
          Length = 1064

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TRDKKG 7
           TRD+KG
Sbjct: 630 TRDRKG 635
>NP_000375
          Length = 4563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    RDKKGVT 9
            +DKKG++
Sbjct: 3992 KDKKGIS 3998
>NP_001245300
          Length = 944

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TRDKKGVT 9
           TRD KG++
Sbjct: 794 TRDAKGLS 801
>NP_001095
          Length = 901

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TRDKKGVT 9
           TRD KG++
Sbjct: 751 TRDAKGLS 758
>NP_001001331
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RDKKGV 8
           +DKKGV
Sbjct: 299 KDKKGV 304
>NP_003310
          Length = 26926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1     STRDKKGV 8
             +TRD +GV
Sbjct: 21524 ATRDHRGV 21531
>NP_597676
          Length = 27051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1     STRDKKGV 8
             +TRD +GV
Sbjct: 21649 ATRDHRGV 21656
>NP_001243779
          Length = 34350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1     STRDKKGV 8
             +TRD +GV
Sbjct: 28948 ATRDHRGV 28955
>NP_596869
          Length = 33423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1     STRDKKGV 8
             +TRD +GV
Sbjct: 28021 ATRDHRGV 28028
>XP_006718528
          Length = 161

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TRDKKG 7
           TRDK+G
Sbjct: 146 TRDKQG 151
>XP_006713243
          Length = 1199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RDKKGV 8
           +DKKGV
Sbjct: 299 KDKKGV 304
>XP_006713242
          Length = 1205

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RDKKGV 8
           +DKKGV
Sbjct: 299 KDKKGV 304
>XP_006713239
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RDKKGV 8
           +DKKGV
Sbjct: 299 KDKKGV 304
>XP_005265236
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RDKKGV 8
           +DKKGV
Sbjct: 299 KDKKGV 304
>XP_006713238
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RDKKGV 8
           +DKKGV
Sbjct: 299 KDKKGV 304
>XP_005246888
          Length = 22663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1     STRDKKGV 8
             +TRD +GV
Sbjct: 17261 ATRDHRGV 17268
>XP_006712788
          Length = 24022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1     STRDKKGV 8
             +TRD +GV
Sbjct: 18620 ATRDHRGV 18627
>XP_006712787
          Length = 33978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1     STRDKKGV 8
             +TRD +GV
Sbjct: 28576 ATRDHRGV 28583
>XP_006712786
          Length = 35484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1     STRDKKGV 8
             +TRD +GV
Sbjct: 30082 ATRDHRGV 30089
>NP_001254479
          Length = 35991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1     STRDKKGV 8
             +TRD +GV
Sbjct: 30589 ATRDHRGV 30596
>NP_597681
          Length = 27118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1     STRDKKGV 8
             +TRD +GV
Sbjct: 21716 ATRDHRGV 21723
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.300    0.118    0.302 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 557,479
Number of extensions: 760
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package