Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              19     869
NP_001075109                                                           19     869
NP_056996                                                              17    2528
XP_005250985                                                           17    2528
XP_006716634                                                           17    2528
NP_006428                                                              17    3301
NP_001087197                                                           16    5631
NP_001248750                                                           16    5631
NP_001248749                                                           16    5631
NP_001248748                                                           16    5631
NP_001248747                                                           16    5631
NP_001248746                                                           16    5631
NP_061149                                                              16    5631
NP_689540                                                              16    5631
XP_006720086                                                           16    5631
XP_006720085                                                           16    5631
XP_006720084                                                           16    5631
XP_005249396                                                           16    5631
XP_006715236                                                           16    5631
XP_005249395                                                           16    5631
XP_005249394                                                           16    5631
XP_006715235                                                           16    5631
NP_001804                                                              15    9605
NP_004658                                                              15    9605
NP_001001670                                                           15    9605
NP_001273663                                                           15    9605
NP_997299                                                              15    9605
NP_001138669                                                           15    9605
NP_055524                                                              15    9605
XP_005276416                                                           15    9605
XP_006720790                                                           15    9605
XP_005268334                                                           15    9605
XP_005268333                                                           15    9605
XP_006720789                                                           15    9605
>NP_008835
          Length = 4128

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    STLSEEVSQ 9
            STLSEE+SQ
Sbjct: 2034 STLSEEMSQ 2042
>NP_001075109
          Length = 4097

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    STLSEEVSQ 9
            STLSEE+SQ
Sbjct: 2034 STLSEEMSQ 2042
>NP_056996
          Length = 1406

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    STLSEEVSQ 9
            STL EEVS+
Sbjct: 1082 STLDEEVSE 1090
>XP_005250985
          Length = 1406

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    STLSEEVSQ 9
            STL EEVS+
Sbjct: 1082 STLDEEVSE 1090
>XP_006716634
          Length = 1420

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    STLSEEVSQ 9
            STL EEVS+
Sbjct: 1096 STLDEEVSE 1104
>NP_006428
          Length = 1724

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   STLSEEVS 8
           STLS+EVS
Sbjct: 257 STLSQEVS 264
>NP_001087197
          Length = 516

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TLSEEVSQ 9
           T+SE+VSQ
Sbjct: 392 TVSEQVSQ 399
>NP_001248750
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TLSEEVSQ 9
           T+SE+VSQ
Sbjct: 316 TVSEQVSQ 323
>NP_001248749
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TLSEEVSQ 9
           T+SE+VSQ
Sbjct: 316 TVSEQVSQ 323
>NP_001248748
          Length = 465

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TLSEEVSQ 9
           T+SE+VSQ
Sbjct: 341 TVSEQVSQ 348
>NP_001248747
          Length = 470

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TLSEEVSQ 9
           T+SE+VSQ
Sbjct: 346 TVSEQVSQ 353
>NP_001248746
          Length = 511

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TLSEEVSQ 9
           T+SE+VSQ
Sbjct: 387 TVSEQVSQ 394
>NP_061149
          Length = 441

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TLSEEVSQ 9
           T+SE+VSQ
Sbjct: 317 TVSEQVSQ 324
>NP_689540
          Length = 723

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   STLSEEVS 8
           S LSEEVS
Sbjct: 134 SALSEEVS 141
>XP_006720086
          Length = 703

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   STLSEEVS 8
           S LSEEVS
Sbjct: 134 SALSEEVS 141
>XP_006720085
          Length = 704

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   STLSEEVS 8
           S LSEEVS
Sbjct: 134 SALSEEVS 141
>XP_006720084
          Length = 730

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   STLSEEVS 8
           S LSEEVS
Sbjct: 134 SALSEEVS 141
>XP_005249396
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TLSEEVSQ 9
           T+SE+VSQ
Sbjct: 238 TVSEQVSQ 245
>XP_006715236
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TLSEEVSQ 9
           T+SE+VSQ
Sbjct: 316 TVSEQVSQ 323
>XP_005249395
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TLSEEVSQ 9
           T+SE+VSQ
Sbjct: 316 TVSEQVSQ 323
>XP_005249394
          Length = 441

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TLSEEVSQ 9
           T+SE+VSQ
Sbjct: 317 TVSEQVSQ 324
>XP_006715235
          Length = 553

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TLSEEVSQ 9
           T+SE+VSQ
Sbjct: 495 TVSEQVSQ 502
>NP_001804
          Length = 2701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STLSEEVSQ 9
           S +SEEVS+
Sbjct: 985 SKISEEVSR 993
>NP_004658
          Length = 4834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STLSEEV 7
            STL+EEV
Sbjct: 2140 STLAEEV 2146
>NP_001001670
          Length = 1576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STLSEEVSQ 9
           STL +++SQ
Sbjct: 276 STLCQDISQ 284
>NP_001273663
          Length = 2580

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STLSEEVSQ 9
           S +SEEVS+
Sbjct: 960 SKISEEVSR 968
>NP_997299
          Length = 917

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STLSEEVSQ 9
           STL +++SQ
Sbjct: 273 STLCQDISQ 281
>NP_001138669
          Length = 917

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STLSEEVSQ 9
           STL +++SQ
Sbjct: 273 STLCQDISQ 281
>NP_055524
          Length = 3546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    STLSEEVSQ 9
            STL+EE S+
Sbjct: 3459 STLAEEESE 3467
>XP_005276416
          Length = 1583

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STLSEEVSQ 9
           STL +++SQ
Sbjct: 262 STLCQDISQ 270
>XP_006720790
          Length = 4748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STLSEEV 7
            STL+EEV
Sbjct: 2054 STLAEEV 2060
>XP_005268334
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STLSEEV 7
            STL+EEV
Sbjct: 2102 STLAEEV 2108
>XP_005268333
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STLSEEV 7
            STL+EEV
Sbjct: 2102 STLAEEV 2108
>XP_006720789
          Length = 4829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    STLSEEV 7
            STL+EEV
Sbjct: 2135 STLAEEV 2141
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.273   0.0931    0.188 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 411,894
Number of extensions: 456
Number of successful extensions: 34
Number of sequences better than 10000.0: 34
Number of HSP's gapped: 34
Number of HSP's successfully gapped: 34
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.5 bits)
S2: 28 (15.4 bits)

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