Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_909119                                                              18    1482
NP_057537                                                              18    1482
NP_722576                                                              18    1482
XP_005262424                                                           18    1482
XP_005265280                                                           18    1482
XP_006713268                                                           18    1482
NP_001243668                                                           18    1935
NP_001243667                                                           18    1935
NP_001243666                                                           18    1935
NP_076939                                                              18    1935
NP_001243669                                                           18    1935
NP_060842                                                              17    4312
NP_001006946                                                           17    4312
XP_005271086                                                           17    4312
NP_056240                                                              16    5631
XP_006712046                                                           16    5631
NP_009107                                                              16    7355
NP_055178                                                              16    7355
NP_001264984                                                           16    7355
NP_115800                                                              16    7355
XP_005266395                                                           16    7355
XP_005271758                                                           16    7355
XP_005271756                                                           16    7355
XP_005271757                                                           16    7355
XP_005271755                                                           16    7355
XP_005271754                                                           16    7355
NP_079110                                                              15    9605
NP_001243307                                                           15    9605
NP_000848                                                              15    9605
NP_001243308                                                           15    9605
NP_001035502                                                           15    9605
NP_001035501                                                           15    9605
NP_004361                                                              15    9605
NP_079105                                                              15    9605
NP_976044                                                              15    9605
NP_001274320                                                           15    9605
NP_001035500                                                           15    9605
XP_006715397                                                           15    9605
>NP_909119
          Length = 715

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   STLLSSVIP 9
           STL+SSV+P
Sbjct: 469 STLVSSVLP 477
>NP_057537
          Length = 722

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   STLLSSVIP 9
           STL+SSV+P
Sbjct: 476 STLVSSVLP 484
>NP_722576
          Length = 3080

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    STLLSSVIP 9
            STLLSSV P
Sbjct: 1589 STLLSSVTP 1597
>XP_005262424
          Length = 2875

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    STLLSSVIP 9
            STLLSSV P
Sbjct: 1384 STLLSSVTP 1392
>XP_005265280
          Length = 644

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   STLLSSVIP 9
           STL+SSV+P
Sbjct: 398 STLVSSVLP 406
>XP_006713268
          Length = 695

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   STLLSSVIP 9
           STL+SSV+P
Sbjct: 476 STLVSSVLP 484
>NP_001243668
          Length = 309

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   STLLSSVIP 9
           +TLLS+VIP
Sbjct: 262 TTLLSAVIP 270
>NP_001243667
          Length = 278

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   STLLSSVIP 9
           +TLLS+VIP
Sbjct: 231 TTLLSAVIP 239
>NP_001243666
          Length = 386

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   STLLSSVIP 9
           +TLLS+VIP
Sbjct: 339 TTLLSAVIP 347
>NP_076939
          Length = 367

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   STLLSSVIP 9
           +TLLS+VIP
Sbjct: 320 TTLLSAVIP 328
>NP_001243669
          Length = 296

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   STLLSSVIP 9
           +TLLS+VIP
Sbjct: 249 TTLLSAVIP 257
>NP_060842
          Length = 769

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STLLSSVIP 9
           S LLSS++P
Sbjct: 663 SQLLSSILP 671
>NP_001006946
          Length = 233

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STLLSSVIP 9
           S LLSS++P
Sbjct: 127 SQLLSSILP 135
>XP_005271086
          Length = 768

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STLLSSVIP 9
           S LLSS++P
Sbjct: 662 SQLLSSILP 670
>NP_056240
          Length = 1720

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STLLSSVIP 9
           STLL ++IP
Sbjct: 689 STLLINIIP 697
>XP_006712046
          Length = 1612

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STLLSSVIP 9
           STLL ++IP
Sbjct: 581 STLLINIIP 589
>NP_009107
          Length = 140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  TLLSSVI 8
          TLLSSVI
Sbjct: 57 TLLSSVI 63
>NP_055178
          Length = 4579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LLSSVIP 9
            LLSSV+P
Sbjct: 3217 LLSSVLP 3223
>NP_001264984
          Length = 4432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LLSSVIP 9
            LLSSV+P
Sbjct: 3070 LLSSVLP 3076
>NP_115800
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LLSSVIP 9
           +LSSVIP
Sbjct: 163 MLSSVIP 169
>XP_005266395
          Length = 4588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LLSSVIP 9
            LLSSV+P
Sbjct: 3226 LLSSVLP 3232
>XP_005271758
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LLSSVIP 9
           +LSSVIP
Sbjct: 163 MLSSVIP 169
>XP_005271756
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LLSSVIP 9
           +LSSVIP
Sbjct: 163 MLSSVIP 169
>XP_005271757
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LLSSVIP 9
           +LSSVIP
Sbjct: 163 MLSSVIP 169
>XP_005271755
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LLSSVIP 9
           +LSSVIP
Sbjct: 163 MLSSVIP 169
>XP_005271754
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LLSSVIP 9
           +LSSVIP
Sbjct: 163 MLSSVIP 169
>NP_079110
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   STLLSSVIP 9
           ++LLS+V+P
Sbjct: 537 NSLLSAVLP 545
>NP_001243307
          Length = 640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   STLLSSVIP 9
           ++LLS+V+P
Sbjct: 535 NSLLSAVLP 543
>NP_000848
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TLLSSVIP 9
           TLL SV+P
Sbjct: 392 TLLYSVLP 399
>NP_001243308
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   STLLSSVIP 9
           ++LLS+V+P
Sbjct: 362 NSLLSAVLP 370
>NP_001035502
          Length = 1031

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   STLLSSVIP 9
           S +LSS IP
Sbjct: 764 SPILSSTIP 772
>NP_001035501
          Length = 1006

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   STLLSSVIP 9
           S +LSS IP
Sbjct: 739 SPILSSTIP 747
>NP_004361
          Length = 3063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  TLLSSVIP 9
          TLLS ++P
Sbjct: 79 TLLSELVP 86
>NP_079105
          Length = 553

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TLLSSVIP 9
           TLL  VIP
Sbjct: 310 TLLKQVIP 317
>NP_976044
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   STLLSSVIP 9
           S +LSS IP
Sbjct: 812 SPILSSTIP 820
>NP_001274320
          Length = 1006

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   STLLSSVIP 9
           S +LSS IP
Sbjct: 739 SPILSSTIP 747
>NP_001035500
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   STLLSSVIP 9
           S +LSS IP
Sbjct: 777 SPILSSTIP 785
>XP_006715397
          Length = 2972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  TLLSSVIP 9
          TLLS ++P
Sbjct: 79 TLLSELVP 86
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.123    0.301 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 336,614
Number of extensions: 571
Number of successful extensions: 38
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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