Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001123914                                                           20     509
NP_005334                                                              20     509
NP_002515                                                              20     509
NP_853510                                                              20     509
NP_004976                                                              18    1135
NP_066301                                                              17    3301
XP_005251088                                                           17    3301
NP_078911                                                              17    4312
NP_001257628                                                           17    4312
NP_001257625                                                           17    4312
NP_001257626                                                           17    4312
NP_001257627                                                           17    4312
NP_001257624                                                           17    4312
NP_060757                                                              17    4312
NP_060427                                                              17    4312
XP_005252701                                                           17    4312
XP_006717604                                                           17    4312
XP_006717603                                                           17    4312
XP_005252185                                                           17    4312
XP_006717294                                                           17    4312
XP_005252184                                                           17    4312
XP_005252183                                                           17    4312
NP_001259004                                                           16    5631
NP_005144                                                              16    5631
NP_006755                                                              16    5631
XP_006721395                                                           16    5631
XP_006721393                                                           16    5631
NP_849188                                                              16    7355
NP_001265238                                                           16    7355
NP_006413                                                              16    7355
NP_066278                                                              16    7355
NP_001258662                                                           16    7355
XP_005253722                                                           16    7355
XP_005253721                                                           16    7355
XP_006719014                                                           16    7355
XP_006713232                                                           16    7355
XP_006713231                                                           16    7355
XP_006713230                                                           16    7355
XP_006713229                                                           16    7355
NP_004031                                                              15    9605
NP_060283                                                              15    9605
NP_001138923                                                           15    9605
NP_786886                                                              15    9605
NP_001036143                                                           15    9605
NP_003076                                                              15    9605
NP_001036144                                                           15    9605
NP_001001502                                                           15    9605
XP_005256177                                                           15    9605
XP_006714979                                                           15    9605
XP_006714978                                                           15    9605
XP_006714977                                                           15    9605
NP_006741                                                              15    9605
>NP_001123914
          Length = 189

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   STKTRQGVE 9
           S KTRQGVE
Sbjct: 145 SAKTRQGVE 153
>NP_005334
          Length = 189

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   STKTRQGVE 9
           S KTRQGVE
Sbjct: 145 SAKTRQGVE 153
>NP_002515
          Length = 189

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   STKTRQGVE 9
           S KTRQGVE
Sbjct: 145 SAKTRQGVE 153
>NP_853510
          Length = 233

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   STKTRQGVE 9
           S KTRQGVE
Sbjct: 181 SAKTRQGVE 189
>NP_004976
          Length = 188

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   STKTRQGVE 9
           S KTRQGV+
Sbjct: 145 SAKTRQGVD 153
>NP_066301
          Length = 538

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TKTRQGVE 9
           T TRQG+E
Sbjct: 402 TGTRQGIE 409
>XP_005251088
          Length = 636

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TKTRQGVE 9
           T TRQG+E
Sbjct: 500 TGTRQGIE 507
>NP_078911
          Length = 725

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STKTRQGVE 9
           ST++RQG E
Sbjct: 210 STRSRQGEE 218
>NP_001257628
          Length = 794

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KTRQGVE 9
           KTRQG E
Sbjct: 494 KTRQGTE 500
>NP_001257625
          Length = 816

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KTRQGVE 9
           KTRQG E
Sbjct: 516 KTRQGTE 522
>NP_001257626
          Length = 799

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KTRQGVE 9
           KTRQG E
Sbjct: 499 KTRQGTE 505
>NP_001257627
          Length = 769

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KTRQGVE 9
           KTRQG E
Sbjct: 469 KTRQGTE 475
>NP_001257624
          Length = 841

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KTRQGVE 9
           KTRQG E
Sbjct: 541 KTRQGTE 547
>NP_060757
          Length = 846

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KTRQGVE 9
           KTRQG E
Sbjct: 546 KTRQGTE 552
>NP_060427
          Length = 632

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   STKTRQGVE 9
           ST+T++G+E
Sbjct: 431 STETKEGLE 439
>XP_005252701
          Length = 794

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KTRQGVE 9
           KTRQG E
Sbjct: 494 KTRQGTE 500
>XP_006717604
          Length = 820

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KTRQGVE 9
           KTRQG E
Sbjct: 546 KTRQGTE 552
>XP_006717603
          Length = 846

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KTRQGVE 9
           KTRQG E
Sbjct: 546 KTRQGTE 552
>XP_005252185
          Length = 569

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  STKTRQGVE 9
          ST++RQG E
Sbjct: 54 STRSRQGEE 62
>XP_006717294
          Length = 692

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STKTRQGVE 9
           ST++RQG E
Sbjct: 210 STRSRQGEE 218
>XP_005252184
          Length = 725

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STKTRQGVE 9
           ST++RQG E
Sbjct: 210 STRSRQGEE 218
>XP_005252183
          Length = 725

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STKTRQGVE 9
           ST++RQG E
Sbjct: 210 STRSRQGEE 218
>NP_001259004
          Length = 802

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STKTRQGVE 9
           +TKT+Q VE
Sbjct: 664 TTKTKQEVE 672
>NP_005144
          Length = 798

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STKTRQGVE 9
           +TKT+Q VE
Sbjct: 660 TTKTKQEVE 668
>NP_006755
          Length = 506

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   STKTRQG 7
           S KTRQG
Sbjct: 152 SAKTRQG 158
>XP_006721395
          Length = 602

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STKTRQGVE 9
           +TKT+Q VE
Sbjct: 464 TTKTKQEVE 472
>XP_006721393
          Length = 781

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STKTRQGVE 9
           +TKT+Q VE
Sbjct: 665 TTKTKQEVE 673
>NP_849188
          Length = 2400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STKTRQGVE 9
            ST+T QG E
Sbjct: 1719 STRTVQGAE 1727
>NP_001265238
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   STKTRQG 7
           STK RQG
Sbjct: 223 STKERQG 229
>NP_006413
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   STKTRQG 7
           STK RQG
Sbjct: 223 STKERQG 229
>NP_066278
          Length = 725

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TKTRQGVE 9
           +KTR+GV+
Sbjct: 397 SKTRKGVQ 404
>NP_001258662
          Length = 689

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TKTRQGVE 9
           +KTR+GV+
Sbjct: 367 SKTRKGVQ 374
>XP_005253722
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   STKTRQG 7
           STK RQG
Sbjct: 223 STKERQG 229
>XP_005253721
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   STKTRQG 7
           STK RQG
Sbjct: 223 STKERQG 229
>XP_006719014
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   STKTRQG 7
           STK RQG
Sbjct: 223 STKERQG 229
>XP_006713232
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TKTRQGVE 9
           +KTR+GV+
Sbjct: 397 SKTRKGVQ 404
>XP_006713231
          Length = 625

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TKTRQGVE 9
           +KTR+GV+
Sbjct: 297 SKTRKGVQ 304
>XP_006713230
          Length = 655

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TKTRQGVE 9
           +KTR+GV+
Sbjct: 397 SKTRKGVQ 404
>XP_006713229
          Length = 680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TKTRQGVE 9
           +KTR+GV+
Sbjct: 352 SKTRKGVQ 359
>NP_004031
          Length = 196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STKTRQGV 8
           S KT++GV
Sbjct: 160 SAKTKEGV 167
>NP_060283
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KTRQGVE 9
           KTR+G E
Sbjct: 97  KTREGAE 103
>NP_001138923
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2 TKTRQG 7
         TKT+QG
Sbjct: 4 TKTKQG 9
>NP_786886
          Length = 193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STKTRQGV 8
           S KT++GV
Sbjct: 160 SAKTKEGV 167
>NP_001036143
          Length = 193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STKTRQGV 8
           S KT++GV
Sbjct: 160 SAKTKEGV 167
>NP_003076
          Length = 134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TKTRQGV 8
          +KTR+GV
Sbjct: 42 SKTREGV 48
>NP_001036144
          Length = 193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STKTRQGV 8
           S KT++GV
Sbjct: 160 SAKTKEGV 167
>NP_001001502
          Length = 134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TKTRQGV 8
          +KTR+GV
Sbjct: 42 SKTREGV 48
>XP_005256177
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TKTRQGVE 9
           T +RQG+E
Sbjct: 239 TGSRQGIE 246
>XP_006714979
          Length = 134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TKTRQGV 8
          +KTR+GV
Sbjct: 42 SKTREGV 48
>XP_006714978
          Length = 152

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TKTRQGV 8
          +KTR+GV
Sbjct: 42 SKTREGV 48
>XP_006714977
          Length = 152

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TKTRQGV 8
          +KTR+GV
Sbjct: 42 SKTREGV 48
>NP_006741
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TKTRQGVE 9
           T +RQG+E
Sbjct: 406 TGSRQGIE 413
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.295    0.110    0.268 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 463,441
Number of extensions: 688
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package