Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002430                                                              20     509
NP_055585                                                              17    3301
NP_001116244                                                           17    3301
XP_005268683                                                           17    3301
XP_005268682                                                           17    3301
NP_055464                                                              16    5631
NP_065694                                                              16    5631
XP_005259745                                                           16    5631
NP_777576                                                              16    7355
NP_872393                                                              16    7355
XP_006712515                                                           16    7355
XP_006712514                                                           16    7355
XP_006712513                                                           16    7355
XP_006712512                                                           16    7355
XP_006712511                                                           16    7355
XP_006712510                                                           16    7355
XP_006712509                                                           16    7355
XP_005246533                                                           16    7355
XP_006712508                                                           16    7355
NP_115893                                                              16    7355
NP_065955                                                              15    9605
NP_001154826                                                           15    9605
NP_061027                                                              15    9605
XP_006723364                                                           15    9605
XP_005259166                                                           15    9605
XP_005259165                                                           15    9605
XP_005259164                                                           15    9605
>NP_002430
          Length = 1137

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   STKAVSRLH 9
           STKAVSR H
Sbjct: 773 STKAVSRFH 781
>NP_055585
          Length = 836

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   STKAVSRLH 9
           S +AVSRLH
Sbjct: 150 SFQAVSRLH 158
>NP_001116244
          Length = 1192

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   STKAVSRLH 9
           S +AVSRLH
Sbjct: 486 SFQAVSRLH 494
>XP_005268683
          Length = 856

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   STKAVSRLH 9
           S +AVSRLH
Sbjct: 150 SFQAVSRLH 158
>XP_005268682
          Length = 1172

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   STKAVSRLH 9
           S +AVSRLH
Sbjct: 486 SFQAVSRLH 494
>NP_055464
          Length = 953

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   STKAVSRLH 9
           +TK +S LH
Sbjct: 461 ATKCISHLH 469
>NP_065694
          Length = 467

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KAVSRLH 9
           KAV RLH
Sbjct: 220 KAVERLH 226
>XP_005259745
          Length = 499

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  STKAVSRLH 9
          +TK +S LH
Sbjct: 7  ATKCISHLH 15
>NP_777576
          Length = 1749

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AVSRLH 9
           AVSRLH
Sbjct: 627 AVSRLH 632
>NP_872393
          Length = 3234

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STKAVSRLH 9
            S +AVSR H
Sbjct: 1714 SARAVSRSH 1722
>XP_006712515
          Length = 3232

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STKAVSRLH 9
            S +AVSR H
Sbjct: 1712 SARAVSRSH 1720
>XP_006712514
          Length = 2496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STKAVSRLH 9
            S +AVSR H
Sbjct: 1785 SARAVSRSH 1793
>XP_006712513
          Length = 3220

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STKAVSRLH 9
            S +AVSR H
Sbjct: 1681 SARAVSRSH 1689
>XP_006712512
          Length = 3237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STKAVSRLH 9
            S +AVSR H
Sbjct: 1717 SARAVSRSH 1725
>XP_006712511
          Length = 3256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STKAVSRLH 9
            S +AVSR H
Sbjct: 1717 SARAVSRSH 1725
>XP_006712510
          Length = 3305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STKAVSRLH 9
            S +AVSR H
Sbjct: 1785 SARAVSRSH 1793
>XP_006712509
          Length = 3319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STKAVSRLH 9
            S +AVSR H
Sbjct: 1780 SARAVSRSH 1788
>XP_005246533
          Length = 3323

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STKAVSRLH 9
            S +AVSR H
Sbjct: 1785 SARAVSRSH 1793
>XP_006712508
          Length = 3324

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STKAVSRLH 9
            S +AVSR H
Sbjct: 1785 SARAVSRSH 1793
>NP_115893
          Length = 3258

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STKAVSRLH 9
            S +AVSR H
Sbjct: 1719 SARAVSRSH 1727
>NP_065955
          Length = 779

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  TKAVSRLH 9
          T+AV+++H
Sbjct: 31 TRAVNKIH 38
>NP_001154826
          Length = 583

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  TKAVSRLH 9
          T+AV+++H
Sbjct: 31 TRAVNKIH 38
>NP_061027
          Length = 4599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    TKAVSRLH 9
            TK++SR H
Sbjct: 3234 TKSLSRAH 3241
>XP_006723364
          Length = 637

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  TKAVSRLH 9
          T+AV+++H
Sbjct: 31 TRAVNKIH 38
>XP_005259166
          Length = 595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  TKAVSRLH 9
          T+AV+++H
Sbjct: 31 TRAVNKIH 38
>XP_005259165
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  TKAVSRLH 9
          T+AV+++H
Sbjct: 31 TRAVNKIH 38
>XP_005259164
          Length = 754

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  TKAVSRLH 9
          T+AV+++H
Sbjct: 31 TRAVNKIH 38
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.113    0.286 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 305,705
Number of extensions: 341
Number of successful extensions: 27
Number of sequences better than 10000.0: 27
Number of HSP's gapped: 27
Number of HSP's successfully gapped: 27
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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