Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              18    1135
XP_005262424                                                           18    1135
NP_001277131                                                           16    5631
NP_849191                                                              16    5631
NP_001092105                                                           16    5631
XP_005248296                                                           16    5631
XP_005248295                                                           16    5631
NP_009208                                                              16    5631
NP_001449                                                              16    7355
NP_001120959                                                           16    7355
NP_006435                                                              16    7355
NP_001036016                                                           16    7355
NP_001252531                                                           16    7355
NP_001036015                                                           16    7355
NP_689801                                                              16    7355
XP_005268737                                                           16    7355
XP_006716996                                                           16    7355
XP_006715973                                                           16    7355
NP_001139661                                                           15    9605
NP_001139662                                                           15    9605
NP_000005                                                              15    9605
NP_060227                                                              15    9605
XP_006726882                                                           15    9605
XP_005276751                                                           15    9605
XP_006726877                                                           15    9605
XP_006726876                                                           15    9605
XP_006726875                                                           15    9605
XP_006726874                                                           15    9605
XP_006726873                                                           15    9605
XP_006724161                                                           15    9605
XP_006724160                                                           15    9605
XP_006724157                                                           15    9605
XP_006724156                                                           15    9605
XP_006724155                                                           15    9605
XP_006724154                                                           15    9605
XP_006724153                                                           15    9605
XP_006722564                                                           15    9605
XP_006722563                                                           15    9605
XP_005266783                                                           15    9605
XP_006719119                                                           15    9605
XP_006710177                                                           15    9605
XP_006710176                                                           15    9605
XP_006710175                                                           15    9605
XP_006710174                                                           15    9605
XP_006710173                                                           15    9605
>NP_722576
          Length = 3080

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    STILTRTI 8
            STILTRTI
Sbjct: 2065 STILTRTI 2072
>XP_005262424
          Length = 2875

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    STILTRTI 8
            STILTRTI
Sbjct: 1860 STILTRTI 1867
>NP_001277131
          Length = 869

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STILTRTIT 9
           +TI+T TIT
Sbjct: 103 TTIITTTIT 111
>NP_849191
          Length = 994

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STILTRTIT 9
           +TI+T TIT
Sbjct: 228 TTIITTTIT 236
>NP_001092105
          Length = 993

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STILTRTIT 9
           +TI+T TIT
Sbjct: 228 TTIITTTIT 236
>XP_005248296
          Length = 630

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TILTRTIT 9
           TIL RT+T
Sbjct: 250 TILERTVT 257
>XP_005248295
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TILTRTIT 9
           TIL RT+T
Sbjct: 250 TILERTVT 257
>NP_009208
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TILTRTIT 9
           TIL RT+T
Sbjct: 250 TILERTVT 257
>NP_001449
          Length = 2725

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    STILTRTIT 9
            ST+L  T+T
Sbjct: 2607 STVLVETVT 2615
>NP_001120959
          Length = 2692

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    STILTRTIT 9
            ST+L  T+T
Sbjct: 2574 STVLVETVT 2582
>NP_006435
          Length = 1197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ILTRTIT 9
           I+TRT+T
Sbjct: 645 IMTRTVT 651
>NP_001036016
          Length = 1197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ILTRTIT 9
           I+TRT+T
Sbjct: 645 IMTRTVT 651
>NP_001252531
          Length = 1197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ILTRTIT 9
           I+TRT+T
Sbjct: 645 IMTRTVT 651
>NP_001036015
          Length = 1197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ILTRTIT 9
           I+TRT+T
Sbjct: 645 IMTRTVT 651
>NP_689801
          Length = 836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TILTRTIT 9
           ++LTRT+T
Sbjct: 265 SLLTRTLT 272
>XP_005268737
          Length = 719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TILTRTIT 9
           ++LTRT+T
Sbjct: 148 SLLTRTLT 155
>XP_006716996
          Length = 1197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ILTRTIT 9
           I+TRT+T
Sbjct: 645 IMTRTVT 651
>XP_006715973
          Length = 2632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    STILTRTIT 9
            ST+L  T+T
Sbjct: 2514 STVLVETVT 2522
>NP_001139661
          Length = 1815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STILTRTI 8
           ST+LTR I
Sbjct: 717 STVLTRHI 724
>NP_001139662
          Length = 1660

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STILTRTI 8
           ST+LTR I
Sbjct: 717 STVLTRHI 724
>NP_000005
          Length = 1474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STILTRTIT 9
           S+ +TRTIT
Sbjct: 340 SSEITRTIT 348
>NP_060227
          Length = 2248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STILTRTI 8
           ST+LTR I
Sbjct: 717 STVLTRHI 724
>XP_006726882
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TILTRTI 8
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_005276751
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TILTRTI 8
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006726877
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TILTRTI 8
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006726876
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TILTRTI 8
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006726875
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TILTRTI 8
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006726874
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TILTRTI 8
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006726873
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TILTRTI 8
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006724161
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TILTRTI 8
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006724160
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TILTRTI 8
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006724157
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TILTRTI 8
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006724156
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TILTRTI 8
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006724155
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TILTRTI 8
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006724154
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TILTRTI 8
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006724153
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TILTRTI 8
          T+LTRT+
Sbjct: 23 TLLTRTL 29
>XP_006722564
          Length = 1628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STILTRTI 8
           ST+LTR I
Sbjct: 717 STVLTRHI 724
>XP_006722563
          Length = 1630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STILTRTI 8
           ST+LTR I
Sbjct: 717 STVLTRHI 724
>XP_005266783
          Length = 2248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   STILTRTI 8
           ST+LTR I
Sbjct: 717 STVLTRHI 724
>XP_006719119
          Length = 1512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   STILTRTIT 9
           S+ +TRTIT
Sbjct: 340 SSEITRTIT 348
>XP_006710177
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TILTRTI 8
          T+LTRT+
Sbjct: 7  TLLTRTL 13
>XP_006710176
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TILTRTI 8
          T+LTRT+
Sbjct: 7  TLLTRTL 13
>XP_006710175
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TILTRTI 8
          T+LTRT+
Sbjct: 7  TLLTRTL 13
>XP_006710174
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TILTRTI 8
          T+LTRT+
Sbjct: 7  TLLTRTL 13
>XP_006710173
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TILTRTI 8
          T+LTRT+
Sbjct: 7  TLLTRTL 13
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.124    0.296 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 321,430
Number of extensions: 447
Number of successful extensions: 45
Number of sequences better than 10000.0: 45
Number of HSP's gapped: 45
Number of HSP's successfully gapped: 45
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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