Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              19     665
XP_005262424                                                           19     665
NP_002007                                                              17    3301
NP_940895                                                              17    4312
NP_001157860                                                           17    4312
NP_001157859                                                           17    4312
NP_001157858                                                           17    4312
NP_057424                                                              17    4312
NP_006260                                                              16    5631
NP_003441                                                              16    5631
NP_001027463                                                           16    5631
NP_001159764                                                           16    5631
NP_003729                                                              16    5631
NP_777583                                                              16    7355
NP_116119                                                              16    7355
NP_001257941                                                           16    7355
NP_001257939                                                           16    7355
NP_001161153                                                           16    7355
NP_002008                                                              16    7355
NP_066022                                                              16    7355
XP_006723369                                                           16    7355
XP_006711061                                                           16    7355
XP_006711060                                                           16    7355
XP_005244868                                                           16    7355
XP_003119848                                                           16    7355
NP_055927                                                              15    9605
NP_976225                                                              15    9605
NP_005446                                                              15    9605
NP_001010905                                                           15    9605
NP_055062                                                              15    9605
NP_116739                                                              15    9605
NP_068757                                                              15    9605
NP_001004326                                                           15    9605
NP_001166144                                                           15    9605
NP_775871                                                              15    9605
XP_006722901                                                           15    9605
XP_006722900                                                           15    9605
XP_006722899                                                           15    9605
XP_006722898                                                           15    9605
XP_006722897                                                           15    9605
XP_006722896                                                           15    9605
XP_006722895                                                           15    9605
XP_005274066                                                           15    9605
XP_006714485                                                           15    9605
XP_005263418                                                           15    9605
XP_005263417                                                           15    9605
XP_006714484                                                           15    9605
XP_005263416                                                           15    9605
XP_006714483                                                           15    9605
XP_005263415                                                           15    9605
XP_005270716                                                           15    9605
XP_006710540                                                           15    9605
XP_006710539                                                           15    9605
XP_005270713                                                           15    9605
XP_005270712                                                           15    9605
XP_005270711                                                           15    9605
XP_005270710                                                           15    9605
XP_006710538                                                           15    9605
XP_005270709                                                           15    9605
>NP_722576
          Length = 3080

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    STHTEASSR 9
            STH EASSR
Sbjct: 2102 STHPEASSR 2110
>XP_005262424
          Length = 2875

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    STHTEASSR 9
            STH EASSR
Sbjct: 1897 STHPEASSR 1905
>NP_002007
          Length = 4061

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    HTEASSR 9
            HTE+SSR
Sbjct: 1981 HTESSSR 1987

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    STHTEASSR 9
            S H EASSR
Sbjct: 1883 SRHHEASSR 1891

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    STHTEASSR 9
            S H EASSR
Sbjct: 2532 SRHHEASSR 2540
>NP_940895
          Length = 266

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   THTEAS 7
           THTEAS
Sbjct: 213 THTEAS 218
>NP_001157860
          Length = 1504

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    STHTEASSR 9
            S+H+E SSR
Sbjct: 1272 SSHSEISSR 1280
>NP_001157859
          Length = 1509

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    STHTEASSR 9
            S+H+E SSR
Sbjct: 1277 SSHSEISSR 1285
>NP_001157858
          Length = 1609

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    STHTEASSR 9
            S+H+E SSR
Sbjct: 1272 SSHSEISSR 1280
>NP_057424
          Length = 1601

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    STHTEASSR 9
            S+H+E SSR
Sbjct: 1264 SSHSEISSR 1272
>NP_006260
          Length = 2156

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   STHTEASSR 9
           STH  +SSR
Sbjct: 264 STHMSSSSR 272
>NP_003441
          Length = 407

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  STHTEASSR 9
          S++TEASS+
Sbjct: 10 SSNTEASSK 18
>NP_001027463
          Length = 234

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  STHTEASSR 9
          S++TEASS+
Sbjct: 10 SSNTEASSK 18
>NP_001159764
          Length = 1146

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   THTEASSR 9
           TH EASS+
Sbjct: 604 THCEASSQ 611
>NP_003729
          Length = 1203

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   THTEASSR 9
           TH EASS+
Sbjct: 604 THCEASSQ 611
>NP_777583
          Length = 283

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   STHTEAS 7
           S HTEAS
Sbjct: 198 SPHTEAS 204
>NP_116119
          Length = 396

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   THTEASS 8
           THT+A+S
Sbjct: 174 THTQAAS 180
>NP_001257941
          Length = 259

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  STHTEASSR 9
          ++HT+ SSR
Sbjct: 12 TSHTDQSSR 20
>NP_001257939
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STHTEASSR 9
           ++HT+ SSR
Sbjct: 139 TSHTDQSSR 147
>NP_001161153
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STHTEASSR 9
           ++HT+ SSR
Sbjct: 172 TSHTDQSSR 180
>NP_002008
          Length = 452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STHTEASSR 9
           ++HT+ SSR
Sbjct: 205 TSHTDQSSR 213
>NP_066022
          Length = 2564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   HTEASSR 9
           H EASSR
Sbjct: 803 HDEASSR 809
>XP_006723369
          Length = 2394

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   HTEASSR 9
           H EASSR
Sbjct: 803 HDEASSR 809
>XP_006711061
          Length = 1553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    HTEASSR 9
            H EASSR
Sbjct: 1419 HREASSR 1425
>XP_006711060
          Length = 1595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    HTEASSR 9
            H EASSR
Sbjct: 1461 HREASSR 1467
>XP_005244868
          Length = 1639

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    HTEASSR 9
            H EASSR
Sbjct: 1505 HREASSR 1511
>XP_003119848
          Length = 515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   HTEASSR 9
           H EASSR
Sbjct: 381 HREASSR 387
>NP_055927
          Length = 1798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STHTEASS 8
           S+HTE+ S
Sbjct: 913 SSHTESDS 920
>NP_976225
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STHTEASSR 9
           S+H+ +SSR
Sbjct: 208 SSHSRSSSR 216
>NP_005446
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   STHTEASSR 9
           S+H+ +SSR
Sbjct: 208 SSHSRSSSR 216
>NP_001010905
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HTEASSR 9
           H+E+SSR
Sbjct: 318 HSESSSR 324
>NP_055062
          Length = 1499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STHTEASSR 9
            S H+E SSR
Sbjct: 1143 SGHSEISSR 1151
>NP_116739
          Length = 93

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  THTEASSR 9
          T TE+SSR
Sbjct: 20 TKTESSSR 27
>NP_068757
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STHTEASS 8
           S+HTEA +
Sbjct: 182 SSHTEAQA 189
>NP_001004326
          Length = 349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  STHTEASS 8
          + HTEAS+
Sbjct: 55 ANHTEAST 62
>NP_001166144
          Length = 409

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STHTEASS 8
           S+HTEA +
Sbjct: 182 SSHTEAQA 189
>NP_775871
          Length = 8384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    STHTEASS 8
            S HTEA++
Sbjct: 7337 SAHTEATT 7344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    STHTEASS 8
            S HTEA++
Sbjct: 7506 SAHTEATT 7513
>XP_006722901
          Length = 371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  STHTEASS 8
          S+HTEA +
Sbjct: 68 SSHTEAQA 75
>XP_006722900
          Length = 371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  STHTEASS 8
          S+HTEA +
Sbjct: 68 SSHTEAQA 75
>XP_006722899
          Length = 382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  STHTEASS 8
          S+HTEA +
Sbjct: 79 SSHTEAQA 86
>XP_006722898
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STHTEASS 8
           S+HTEA +
Sbjct: 182 SSHTEAQA 189
>XP_006722897
          Length = 457

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STHTEASS 8
           S+HTEA +
Sbjct: 182 SSHTEAQA 189
>XP_006722896
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STHTEASS 8
           S+HTEA +
Sbjct: 181 SSHTEAQA 188
>XP_006722895
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STHTEASS 8
           S+HTEA +
Sbjct: 182 SSHTEAQA 189
>XP_005274066
          Length = 349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  STHTEASS 8
          + HTEAS+
Sbjct: 55 ANHTEAST 62
>XP_006714485
          Length = 1585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STHTEASSR 9
            S H+E SSR
Sbjct: 1229 SGHSEISSR 1237
>XP_005263418
          Length = 1654

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STHTEASSR 9
            S H+E SSR
Sbjct: 1298 SGHSEISSR 1306
>XP_005263417
          Length = 1660

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STHTEASSR 9
            S H+E SSR
Sbjct: 1304 SGHSEISSR 1312
>XP_006714484
          Length = 1685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STHTEASSR 9
            S H+E SSR
Sbjct: 1329 SGHSEISSR 1337
>XP_005263416
          Length = 1693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STHTEASSR 9
            S H+E SSR
Sbjct: 1337 SGHSEISSR 1345
>XP_006714483
          Length = 1695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STHTEASSR 9
            S H+E SSR
Sbjct: 1339 SGHSEISSR 1347
>XP_005263415
          Length = 1701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    STHTEASSR 9
            S H+E SSR
Sbjct: 1345 SGHSEISSR 1353
>XP_005270716
          Length = 1332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STHTEASS 8
           S+HTE+ S
Sbjct: 920 SSHTESDS 927
>XP_006710540
          Length = 1655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STHTEASS 8
           S+HTE+ S
Sbjct: 770 SSHTESDS 777
>XP_006710539
          Length = 1683

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STHTEASS 8
           S+HTE+ S
Sbjct: 798 SSHTESDS 805
>XP_005270713
          Length = 1711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STHTEASS 8
           S+HTE+ S
Sbjct: 826 SSHTESDS 833
>XP_005270712
          Length = 1720

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STHTEASS 8
           S+HTE+ S
Sbjct: 835 SSHTESDS 842
>XP_005270711
          Length = 1797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STHTEASS 8
           S+HTE+ S
Sbjct: 913 SSHTESDS 920
>XP_005270710
          Length = 1804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STHTEASS 8
           S+HTE+ S
Sbjct: 920 SSHTESDS 927
>XP_006710538
          Length = 1804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STHTEASS 8
           S+HTE+ S
Sbjct: 919 SSHTESDS 926
>XP_005270709
          Length = 1805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   STHTEASS 8
           S+HTE+ S
Sbjct: 920 SSHTESDS 927
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.284   0.0891    0.211 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 551,838
Number of extensions: 620
Number of successful extensions: 62
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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