Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001257436                                                           21     175
NP_001257437                                                           21     175
NP_006281                                                              21     175
XP_006715618                                                           21     175
XP_005267176                                                           21     175
NP_003817                                                              17    3301
NP_001451                                                              17    4312
NP_775832                                                              17    4312
XP_005245096                                                           17    4312
NP_001072996                                                           16    5631
NP_001162                                                              16    5631
NP_001058                                                              16    5631
NP_001136157                                                           16    5631
NP_055530                                                              16    5631
NP_938015                                                              16    5631
NP_055509                                                              16    5631
NP_001138792                                                           16    5631
NP_060009                                                              16    5631
NP_001059                                                              16    5631
XP_005255367                                                           16    5631
XP_006725257                                                           16    5631
XP_006725256                                                           16    5631
XP_005257689                                                           16    5631
XP_006721125                                                           16    5631
XP_006719124                                                           16    5631
XP_005253405                                                           16    5631
XP_005271793                                                           16    5631
XP_005272296                                                           16    5631
XP_006717400                                                           16    5631
XP_005272295                                                           16    5631
XP_006717399                                                           16    5631
XP_005272294                                                           16    5631
XP_005265484                                                           16    5631
XP_005264213                                                           16    5631
NP_787054                                                              16    5631
NP_777601                                                              16    5631
NP_065761                                                              16    7355
NP_003301                                                              16    7355
XP_005247497                                                           15    9605
NP_001078889                                                           15    9605
>NP_001257436
          Length = 790

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   STCFKRTAA 9
           STCFKRT A
Sbjct: 537 STCFKRTTA 545
>NP_001257437
          Length = 790

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   STCFKRTAA 9
           STCFKRT A
Sbjct: 537 STCFKRTTA 545
>NP_006281
          Length = 790

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   STCFKRTAA 9
           STCFKRT A
Sbjct: 537 STCFKRTTA 545
>XP_006715618
          Length = 577

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   STCFKRTAA 9
           STCFKRT A
Sbjct: 324 STCFKRTTA 332
>XP_005267176
          Length = 790

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   STCFKRTAA 9
           STCFKRT A
Sbjct: 537 STCFKRTTA 545
>NP_003817
          Length = 312

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TCFKRTAA 9
           TC+K+T A
Sbjct: 192 TCYKKTIA 199
>NP_001451
          Length = 471

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  TCFKRT 7
          TCF+RT
Sbjct: 29 TCFERT 34
>NP_775832
          Length = 518

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   STCFKRTAA 9
           S CF+R AA
Sbjct: 343 SFCFRRKAA 351
>XP_005245096
          Length = 416

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  TCFKRT 7
          TCF+RT
Sbjct: 29 TCFERT 34
>NP_001072996
          Length = 99

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  STCFKRTA 8
          S CF RTA
Sbjct: 28 SLCFLRTA 35
>NP_001162
          Length = 1503

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  STCFKRTA 8
          S CF RTA
Sbjct: 28 SLCFLRTA 35
>NP_001058
          Length = 1531

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   TCFKR 6
           TCFKR
Sbjct: 732 TCFKR 736
>NP_001136157
          Length = 2087

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   STCFKRTAA 9
           S CF  TAA
Sbjct: 537 SACFSGTAA 545
>NP_055530
          Length = 1738

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   STCFKRTAA 9
           S CF  TAA
Sbjct: 188 SACFSGTAA 196
>NP_938015
          Length = 490

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2  TCFKR 6
          TCFKR
Sbjct: 54 TCFKR 58
>NP_055509
          Length = 951

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   STCFKR 6
           STCF+R
Sbjct: 847 STCFER 852
>NP_001138792
          Length = 951

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   STCFKR 6
           STCF+R
Sbjct: 847 STCFER 852
>NP_060009
          Length = 4116

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    STCFKRT 7
            S CFK+T
Sbjct: 2333 SNCFKQT 2339
>NP_001059
          Length = 1621

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   TCFKR 6
           TCFKR
Sbjct: 748 TCFKR 752
>XP_005255367
          Length = 972

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   STCFKRTA 8
           S CF RTA
Sbjct: 129 SLCFLRTA 136
>XP_006725257
          Length = 972

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   STCFKRTA 8
           S CF RTA
Sbjct: 129 SLCFLRTA 136
>XP_006725256
          Length = 979

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   STCFKRTA 8
           S CF RTA
Sbjct: 129 SLCFLRTA 136
>XP_005257689
          Length = 1519

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   TCFKR 6
           TCFKR
Sbjct: 720 TCFKR 724
>XP_006721125
          Length = 4070

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    STCFKRT 7
            S CFK+T
Sbjct: 2287 SNCFKQT 2293
>XP_006719124
          Length = 1047

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TCFKRTAA 9
           TCF+R+ A
Sbjct: 467 TCFRRSDA 474
>XP_005253405
          Length = 1463

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TCFKRTAA 9
           TCF+R+ A
Sbjct: 467 TCFRRSDA 474
>XP_005271793
          Length = 2061

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   STCFKRTAA 9
           S CF  TAA
Sbjct: 511 SACFSGTAA 519
>XP_005272296
          Length = 951

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   STCFKR 6
           STCF+R
Sbjct: 847 STCFER 852
>XP_006717400
          Length = 951

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   STCFKR 6
           STCF+R
Sbjct: 847 STCFER 852
>XP_005272295
          Length = 961

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   STCFKR 6
           STCF+R
Sbjct: 857 STCFER 862
>XP_006717399
          Length = 1002

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   STCFKR 6
           STCF+R
Sbjct: 956 STCFER 961
>XP_005272294
          Length = 1060

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   STCFKR 6
           STCF+R
Sbjct: 956 STCFER 961
>XP_005265484
          Length = 1626

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   TCFKR 6
           TCFKR
Sbjct: 753 TCFKR 757
>XP_005264213
          Length = 477

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2  TCFKR 6
          TCFKR
Sbjct: 54 TCFKR 58
>NP_787054
          Length = 163

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  TCFKRTA 8
          TC++RT+
Sbjct: 69 TCYRRTS 75
>NP_777601
          Length = 1453

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TCFKRTAA 9
           TCF+R+ A
Sbjct: 457 TCFRRSDA 464
>NP_065761
          Length = 583

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   CFKRTAA 9
           C KRTAA
Sbjct: 367 CEKRTAA 373
>NP_003301
          Length = 387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  STCFKRTA 8
          +TC+ RT+
Sbjct: 81 TTCYNRTS 88
>XP_005247497
          Length = 259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  STCFKRT 7
          S CF RT
Sbjct: 93 SICFNRT 99
>NP_001078889
          Length = 271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   STCFKRT 7
           S CF RT
Sbjct: 105 SICFNRT 111
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.118    0.373 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 556,184
Number of extensions: 611
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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