Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004251                                                              18    1135
NP_071902                                                              17    2528
NP_001001740                                                           17    2528
NP_001273573                                                           17    2528
NP_001254652                                                           17    2528
XP_005259249                                                           17    2528
XP_005259248                                                           17    2528
XP_006711552                                                           17    2528
XP_006711551                                                           17    2528
XP_006711550                                                           17    2528
XP_005245505                                                           17    2528
XP_005245504                                                           17    2528
NP_001073945                                                           17    3301
NP_060896                                                              17    4312
XP_005249274                                                           17    4312
XP_005249273                                                           17    4312
XP_005249272                                                           17    4312
XP_005249271                                                           17    4312
XP_006715198                                                           17    4312
XP_005249269                                                           17    4312
XP_005249270                                                           17    4312
XP_005249268                                                           17    4312
NP_056023                                                              16    5631
NP_001190985                                                           16    5631
NP_001077094                                                           16    5631
XP_006722380                                                           16    5631
XP_005258153                                                           16    5631
XP_005258152                                                           16    5631
XP_005258151                                                           16    5631
XP_005258150                                                           16    5631
XP_005258149                                                           16    5631
NP_001866                                                              16    7355
NP_001245340                                                           16    7355
NP_001245342                                                           16    7355
NP_443176                                                              16    7355
NP_001245341                                                           16    7355
NP_004332                                                              16    7355
NP_001254542                                                           16    7355
NP_001116105                                                           16    7355
NP_001116106                                                           16    7355
NP_001254539                                                           16    7355
NP_001254543                                                           16    7355
NP_722561                                                              16    7355
NP_001254538                                                           16    7355
NP_001254540                                                           16    7355
NP_001254541                                                           16    7355
NP_001245343                                                           16    7355
XP_005255139                                                           16    7355
XP_006721078                                                           16    7355
XP_005255138                                                           16    7355
XP_006721077                                                           16    7355
XP_005255137                                                           16    7355
XP_005264615                                                           16    7355
XP_006712164                                                           16    7355
XP_005264614                                                           16    7355
XP_005264613                                                           16    7355
XP_005264612                                                           16    7355
XP_006711316                                                           16    7355
XP_005245114                                                           16    7355
XP_005245113                                                           16    7355
XP_006711315                                                           16    7355
XP_005245112                                                           16    7355
XP_006711314                                                           16    7355
NP_079285                                                              15    9605
XP_005265845                                                           15    9605
XP_006714118                                                           15    9605
XP_005248231                                                           15    9605
NP_060793                                                              15    9605
NP_067680                                                              15    9605
>NP_004251
          Length = 1208

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SSSVEFDRV 9
           SSSVEFD V
Sbjct: 982 SSSVEFDMV 990
>NP_071902
          Length = 731

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSVEFDR 8
           SS+EFDR
Sbjct: 425 SSIEFDR 431
>NP_001001740
          Length = 707

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSVEFDR 8
           SS+EFDR
Sbjct: 401 SSIEFDR 407
>NP_001273573
          Length = 491

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSVEFDR 8
           SS+EFDR
Sbjct: 185 SSIEFDR 191
>NP_001254652
          Length = 512

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SVEFDRV 9
           SVEFDR+
Sbjct: 125 SVEFDRI 131
>XP_005259249
          Length = 512

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SVEFDRV 9
           SVEFDR+
Sbjct: 125 SVEFDRI 131
>XP_005259248
          Length = 520

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SVEFDRV 9
           SVEFDR+
Sbjct: 133 SVEFDRI 139
>XP_006711552
          Length = 420

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSVEFDR 8
           SS+EFDR
Sbjct: 114 SSIEFDR 120
>XP_006711551
          Length = 589

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSVEFDR 8
           SS+EFDR
Sbjct: 425 SSIEFDR 431
>XP_006711550
          Length = 708

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSVEFDR 8
           SS+EFDR
Sbjct: 402 SSIEFDR 408
>XP_005245505
          Length = 711

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSVEFDR 8
           SS+EFDR
Sbjct: 405 SSIEFDR 411
>XP_005245504
          Length = 727

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSVEFDR 8
           SS+EFDR
Sbjct: 421 SSIEFDR 427
>NP_001073945
          Length = 290

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSSVEFDRV 9
           S+ +EFDRV
Sbjct: 131 STDLEFDRV 139
>NP_060896
          Length = 832

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SSSVEFDR 8
           SSSV+FD+
Sbjct: 113 SSSVDFDQ 120
>XP_005249274
          Length = 832

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SSSVEFDR 8
           SSSV+FD+
Sbjct: 113 SSSVDFDQ 120
>XP_005249273
          Length = 814

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SSSVEFDR 8
           SSSV+FD+
Sbjct: 122 SSSVDFDQ 129
>XP_005249272
          Length = 819

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SSSVEFDR 8
           SSSV+FD+
Sbjct: 100 SSSVDFDQ 107
>XP_005249271
          Length = 828

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SSSVEFDR 8
           SSSV+FD+
Sbjct: 109 SSSVDFDQ 116
>XP_006715198
          Length = 832

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SSSVEFDR 8
           SSSV+FD+
Sbjct: 113 SSSVDFDQ 120
>XP_005249269
          Length = 832

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SSSVEFDR 8
           SSSV+FD+
Sbjct: 113 SSSVDFDQ 120
>XP_005249270
          Length = 832

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SSSVEFDR 8
           SSSV+FD+
Sbjct: 113 SSSVDFDQ 120
>XP_005249268
          Length = 841

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SSSVEFDR 8
           SSSV+FD+
Sbjct: 122 SSSVDFDQ 129
>NP_056023
          Length = 2062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SVEFDR 8
           SVEFDR
Sbjct: 688 SVEFDR 693
>NP_001190985
          Length = 2039

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SVEFDR 8
           SVEFDR
Sbjct: 665 SVEFDR 670
>NP_001077094
          Length = 2039

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SVEFDR 8
           SVEFDR
Sbjct: 665 SVEFDR 670
>XP_006722380
          Length = 1769

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SVEFDR 8
           SVEFDR
Sbjct: 395 SVEFDR 400
>XP_005258153
          Length = 2037

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SVEFDR 8
           SVEFDR
Sbjct: 663 SVEFDR 668
>XP_005258152
          Length = 2060

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SVEFDR 8
           SVEFDR
Sbjct: 686 SVEFDR 691
>XP_005258151
          Length = 2062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SVEFDR 8
           SVEFDR
Sbjct: 688 SVEFDR 693
>XP_005258150
          Length = 2062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SVEFDR 8
           SVEFDR
Sbjct: 688 SVEFDR 693
>XP_005258149
          Length = 2062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SVEFDR 8
           SVEFDR
Sbjct: 688 SVEFDR 693
>NP_001866
          Length = 1500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSVEFD 7
           SSVEFD
Sbjct: 988 SSVEFD 993
>NP_001245340
          Length = 640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSSVEFDRV 9
           SSSV+F+ V
Sbjct: 555 SSSVQFEMV 563
>NP_001245342
          Length = 611

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSSVEFDRV 9
           SSSV+F+ V
Sbjct: 526 SSSVQFEMV 534
>NP_443176
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSSVEFDRV 9
           SSSV+F+ V
Sbjct: 590 SSSVQFEMV 598
>NP_001245341
          Length = 605

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSSVEFDRV 9
           SSSV+F+ V
Sbjct: 520 SSSVQFEMV 528
>NP_004332
          Length = 2225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSVEFD 7
           SSVEFD
Sbjct: 947 SSVEFD 952
>NP_001254542
          Length = 451

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  SSVEFD 7
          SSVEFD
Sbjct: 89 SSVEFD 94
>NP_001116105
          Length = 1506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSVEFD 7
           SSVEFD
Sbjct: 994 SSVEFD 999
>NP_001116106
          Length = 1049

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSVEFD 7
           SSVEFD
Sbjct: 537 SSVEFD 542
>NP_001254539
          Length = 529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSVEFD 7
           SSVEFD
Sbjct: 167 SSVEFD 172
>NP_001254543
          Length = 415

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  SSVEFD 7
          SSVEFD
Sbjct: 53 SSVEFD 58
>NP_722561
          Length = 529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSVEFD 7
           SSVEFD
Sbjct: 167 SSVEFD 172
>NP_001254538
          Length = 549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSVEFD 7
           SSVEFD
Sbjct: 187 SSVEFD 192
>NP_001254540
          Length = 546

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSVEFD 7
           SSVEFD
Sbjct: 184 SSVEFD 189
>NP_001254541
          Length = 397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  SSVEFD 7
          SSVEFD
Sbjct: 35 SSVEFD 40
>NP_001245343
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSSVEFDRV 9
           SSSV+F+ V
Sbjct: 434 SSSVQFEMV 442
>XP_005255139
          Length = 514

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSSVEFDRV 9
           SSSV+F+ V
Sbjct: 429 SSSVQFEMV 437
>XP_006721078
          Length = 576

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSSVEFDRV 9
           SSSV+F+ V
Sbjct: 491 SSSVQFEMV 499
>XP_005255138
          Length = 583

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSSVEFDRV 9
           SSSV+F+ V
Sbjct: 498 SSSVQFEMV 506
>XP_006721077
          Length = 655

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSSVEFDRV 9
           SSSV+F+ V
Sbjct: 570 SSSVQFEMV 578
>XP_005255137
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSSVEFDRV 9
           SSSV+F+ V
Sbjct: 590 SSSVQFEMV 598
>XP_005264615
          Length = 2162

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSVEFD 7
           SSVEFD
Sbjct: 884 SSVEFD 889
>XP_006712164
          Length = 2179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSVEFD 7
           SSVEFD
Sbjct: 884 SSVEFD 889
>XP_005264614
          Length = 2191

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSVEFD 7
           SSVEFD
Sbjct: 947 SSVEFD 952
>XP_005264613
          Length = 2208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSVEFD 7
           SSVEFD
Sbjct: 947 SSVEFD 952
>XP_005264612
          Length = 2242

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSVEFD 7
           SSVEFD
Sbjct: 947 SSVEFD 952
>XP_006711316
          Length = 529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSVEFD 7
           SSVEFD
Sbjct: 167 SSVEFD 172
>XP_005245114
          Length = 529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSVEFD 7
           SSVEFD
Sbjct: 167 SSVEFD 172
>XP_005245113
          Length = 529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSVEFD 7
           SSVEFD
Sbjct: 167 SSVEFD 172
>XP_006711315
          Length = 529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSVEFD 7
           SSVEFD
Sbjct: 167 SSVEFD 172
>XP_005245112
          Length = 549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSVEFD 7
           SSVEFD
Sbjct: 187 SSVEFD 192
>XP_006711314
          Length = 552

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSVEFD 7
           SSVEFD
Sbjct: 190 SSVEFD 195
>NP_079285
          Length = 1140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SSSVEFDRV 9
            S ++EF+RV
Sbjct: 997  SKNLEFERV 1005
>XP_005265845
          Length = 783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SSSVEFDRV 9
           S ++EF+RV
Sbjct: 640 SKNLEFERV 648
>XP_006714118
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SSSVEFDRV 9
           S ++EF+RV
Sbjct: 986 SKNLEFERV 994
>XP_005248231
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  SSSVEFDR 8
          SSS E DR
Sbjct: 76 SSSAELDR 83
>NP_060793
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  SSSVEFDR 8
          SSS E DR
Sbjct: 76 SSSAELDR 83
>NP_067680
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SSVEFDRV 9
           S +EFDR+
Sbjct: 362 SLLEFDRI 369
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.121    0.293 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 445,248
Number of extensions: 458
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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