Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              19     869
XP_006717989                                                           19     869
NP_079221                                                              18    1135
XP_005252270                                                           18    1135
XP_005252268                                                           18    1135
NP_004652                                                              18    1935
NP_001156495                                                           17    4312
NP_001156494                                                           17    4312
NP_060944                                                              17    4312
NP_001263318                                                           17    4312
NP_001164056                                                           17    4312
NP_694566                                                              17    4312
XP_006715303                                                           17    4312
NP_001094809                                                           16    5631
NP_775837                                                              16    5631
NP_056346                                                              16    5631
NP_006725                                                              16    5631
NP_001273506                                                           16    5631
XP_006724284                                                           16    5631
XP_006724283                                                           16    5631
XP_006724282                                                           16    5631
XP_005261537                                                           16    5631
XP_005273954                                                           16    5631
XP_005273953                                                           16    5631
XP_005273952                                                           16    5631
XP_005273950                                                           16    5631
XP_005267014                                                           16    5631
NP_001161210                                                           16    7355
NP_065176                                                              16    7355
NP_000831                                                              16    7355
NP_060572                                                              16    7355
NP_001257426                                                           16    7355
NP_115598                                                              16    7355
XP_006723883                                                           16    7355
XP_006723882                                                           16    7355
XP_006723881                                                           16    7355
XP_006723880                                                           16    7355
XP_005260504                                                           16    7355
XP_006723879                                                           16    7355
XP_006711674                                                           16    7355
XP_006711673                                                           16    7355
XP_006711672                                                           16    7355
XP_006711671                                                           16    7355
XP_006711670                                                           16    7355
XP_005245629                                                           16    7355
NP_694998                                                              16    7355
NP_001155048                                                           15    9605
NP_056404                                                              15    9605
NP_056982                                                              15    9605
NP_001155049                                                           15    9605
NP_005198                                                              15    9605
NP_055928                                                              15    9605
NP_001268450                                                           15    9605
NP_689955                                                              15    9605
NP_001026859                                                           15    9605
NP_031398                                                              15    9605
NP_987095                                                              15    9605
XP_005259627                                                           15    9605
XP_005259628                                                           15    9605
XP_005259629                                                           15    9605
XP_006721720                                                           15    9605
XP_005256619                                                           15    9605
XP_006721549                                                           15    9605
XP_006721548                                                           15    9605
XP_005256618                                                           15    9605
XP_005256617                                                           15    9605
XP_006715956                                                           15    9605
XP_006715955                                                           15    9605
NP_940934                                                              15    9605
>NP_000305
          Length = 403

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SSNSVPTRR 9
           SSNS PTRR
Sbjct: 226 SSNSGPTRR 234
>XP_006717989
          Length = 388

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SSNSVPTRR 9
           SSNS PTRR
Sbjct: 211 SSNSGPTRR 219
>NP_079221
          Length = 625

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SSNSVPTRR 9
           SSN++PTR+
Sbjct: 274 SSNTIPTRQ 282
>XP_005252270
          Length = 625

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SSNSVPTRR 9
           SSN++PTR+
Sbjct: 274 SSNTIPTRQ 282
>XP_005252268
          Length = 625

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SSNSVPTRR 9
           SSN++PTR+
Sbjct: 274 SSNTIPTRQ 282
>NP_004652
          Length = 597

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSNSVPTRR 9
           S+N+ PTRR
Sbjct: 578 SANNTPTRR 586
>NP_001156495
          Length = 540

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   NSVPTR 8
           NSVPTR
Sbjct: 397 NSVPTR 402
>NP_001156494
          Length = 570

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   NSVPTR 8
           NSVPTR
Sbjct: 427 NSVPTR 432
>NP_060944
          Length = 673

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   NSVPTR 8
           NSVPTR
Sbjct: 530 NSVPTR 535
>NP_001263318
          Length = 624

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   NSVPTR 8
           NSVPTR
Sbjct: 481 NSVPTR 486
>NP_001164056
          Length = 1447

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    SSNSVPT 7
            +SNSVPT
Sbjct: 1067 ASNSVPT 1073
>NP_694566
          Length = 1458

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    SSNSVPT 7
            +SNSVPT
Sbjct: 1078 ASNSVPT 1084
>XP_006715303
          Length = 1463

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SSNSVPTRR 9
            S+N++PTR+
Sbjct: 1454 SANALPTRQ 1462
>NP_001094809
          Length = 145

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  SSNSVPT 7
          SSN VPT
Sbjct: 49 SSNKVPT 55
>NP_775837
          Length = 2151

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SSNSVPTR 8
            SSN +PT+
Sbjct: 1553 SSNPIPTK 1560
>NP_056346
          Length = 1963

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SSNSVPTR 8
           SSN++PT+
Sbjct: 307 SSNNLPTK 314
>NP_006725
          Length = 2446

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SNSVPT 7
           SNSVPT
Sbjct: 543 SNSVPT 548
>NP_001273506
          Length = 2353

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SSNSVPTR 8
           SSN++PT+
Sbjct: 307 SSNNLPTK 314
>XP_006724284
          Length = 1989

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SSNSVPTR 8
            SSN +PT+
Sbjct: 1391 SSNPIPTK 1398
>XP_006724283
          Length = 2151

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SSNSVPTR 8
            SSN +PT+
Sbjct: 1553 SSNPIPTK 1560
>XP_006724282
          Length = 2151

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SSNSVPTR 8
            SSN +PT+
Sbjct: 1553 SSNPIPTK 1560
>XP_005261537
          Length = 2151

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SSNSVPTR 8
            SSN +PT+
Sbjct: 1553 SSNPIPTK 1560
>XP_005273954
          Length = 1676

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SSNSVPTR 8
           SSN++PT+
Sbjct: 307 SSNNLPTK 314
>XP_005273953
          Length = 2171

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SSNSVPTR 8
           SSN++PT+
Sbjct: 124 SSNNLPTK 131
>XP_005273952
          Length = 2245

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SSNSVPTR 8
           SSN++PT+
Sbjct: 198 SSNNLPTK 205
>XP_005273950
          Length = 2354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SSNSVPTR 8
           SSN++PT+
Sbjct: 307 SSNNLPTK 314
>XP_005267014
          Length = 2446

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SNSVPT 7
           SNSVPT
Sbjct: 543 SNSVPT 548
>NP_001161210
          Length = 1483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SNSVPT 7
           SNS+PT
Sbjct: 621 SNSIPT 626
>NP_065176
          Length = 1877

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SNSVPT 7
            SNS+PT
Sbjct: 1012 SNSIPT 1017
>NP_000831
          Length = 879

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SSNSVPT 7
           S NSVPT
Sbjct: 500 SRNSVPT 506
>NP_060572
          Length = 680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSVPTRR 9
           NSVP+R+
Sbjct: 125 NSVPSRK 131
>NP_001257426
          Length = 679

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSVPTRR 9
           NSVP+R+
Sbjct: 124 NSVPSRK 130
>NP_115598
          Length = 757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SSNSVPTR 8
           SSNS P+R
Sbjct: 262 SSNSSPSR 269
>XP_006723883
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSVPTRR 9
           NSVP+R+
Sbjct: 120 NSVPSRK 126
>XP_006723882
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSVPTRR 9
           NSVP+R+
Sbjct: 120 NSVPSRK 126
>XP_006723881
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSVPTRR 9
           NSVP+R+
Sbjct: 120 NSVPSRK 126
>XP_006723880
          Length = 680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSVPTRR 9
           NSVP+R+
Sbjct: 125 NSVPSRK 131
>XP_005260504
          Length = 680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSVPTRR 9
           NSVP+R+
Sbjct: 125 NSVPSRK 131
>XP_006723879
          Length = 703

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSVPTRR 9
           NSVP+R+
Sbjct: 148 NSVPSRK 154
>XP_006711674
          Length = 1385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SNSVPT 7
           SNS+PT
Sbjct: 520 SNSIPT 525
>XP_006711673
          Length = 1549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SNSVPT 7
           SNS+PT
Sbjct: 692 SNSIPT 697
>XP_006711672
          Length = 1557

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SNSVPT 7
           SNS+PT
Sbjct: 692 SNSIPT 697
>XP_006711671
          Length = 2153

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SNSVPT 7
            SNS+PT
Sbjct: 1299 SNSIPT 1304
>XP_006711670
          Length = 2161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SNSVPT 7
            SNS+PT
Sbjct: 1299 SNSIPT 1304
>XP_005245629
          Length = 2164

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SNSVPT 7
            SNS+PT
Sbjct: 1299 SNSIPT 1304
>NP_694998
          Length = 468

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SSNSVPTRR 9
           SSNS+P  R
Sbjct: 385 SSNSLPPAR 393
>NP_001155048
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SNSVPTR 8
           SNS+P+R
Sbjct: 561 SNSMPSR 567
>NP_056404
          Length = 718

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SNSVPTR 8
           SNS+P+R
Sbjct: 649 SNSMPSR 655
>NP_056982
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NSVPTRR 9
           N VP+RR
Sbjct: 491 NGVPSRR 497
>NP_001155049
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SNSVPTR 8
           SNS+P+R
Sbjct: 240 SNSMPSR 246
>NP_005198
          Length = 303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  NSVPTRR 9
          NS+P RR
Sbjct: 64 NSLPNRR 70
>NP_055928
          Length = 2961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    SNSVPTRR 9
            S S PTRR
Sbjct: 1518 SPSTPTRR 1525
>NP_001268450
          Length = 880

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SSNSVPT 7
           SSNS PT
Sbjct: 433 SSNSSPT 439
>NP_689955
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   SSNSVPTRR 9
           S   VPTRR
Sbjct: 461 SGPDVPTRR 469
>NP_001026859
          Length = 795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SSNSVPT 7
           SSN++PT
Sbjct: 484 SSNTLPT 490
>NP_031398
          Length = 938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SSNSVPT 7
           S NSVPT
Sbjct: 736 SLNSVPT 742
>NP_987095
          Length = 938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SSNSVPT 7
           S NSVPT
Sbjct: 736 SLNSVPT 742
>XP_005259627
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NSVPTRR 9
           N VP+RR
Sbjct: 491 NGVPSRR 497
>XP_005259628
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NSVPTRR 9
           N VP+RR
Sbjct: 491 NGVPSRR 497
>XP_005259629
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NSVPTRR 9
           N VP+RR
Sbjct: 491 NGVPSRR 497
>XP_006721720
          Length = 938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SSNSVPT 7
           S NSVPT
Sbjct: 736 SLNSVPT 742
>XP_005256619
          Length = 1581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SNSVPTRR 9
           S S PTRR
Sbjct: 134 SPSTPTRR 141
>XP_006721549
          Length = 1581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SNSVPTRR 9
           S S PTRR
Sbjct: 134 SPSTPTRR 141
>XP_006721548
          Length = 1886

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SNSVPTRR 9
           S S PTRR
Sbjct: 439 SPSTPTRR 446
>XP_005256618
          Length = 2962

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    SNSVPTRR 9
            S S PTRR
Sbjct: 1519 SPSTPTRR 1526
>XP_005256617
          Length = 2966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    SNSVPTRR 9
            S S PTRR
Sbjct: 1519 SPSTPTRR 1526
>XP_006715956
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   SSNSVPTRR 9
           S   VPTRR
Sbjct: 207 SGPDVPTRR 215
>XP_006715955
          Length = 364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   SSNSVPTRR 9
           S   VPTRR
Sbjct: 246 SGPDVPTRR 254
>NP_940934
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  SNSVPTRR 9
          + S+PTRR
Sbjct: 67 TQSLPTRR 74
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.298    0.107    0.276 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 713,293
Number of extensions: 1095
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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