Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     509
XP_005262424                                                           20     509
NP_001138537                                                           18    1482
NP_997374                                                              18    1482
XP_006726821                                                           17    2528
XP_006726817                                                           17    2528
XP_006726816                                                           17    2528
XP_006726811                                                           17    2528
XP_006726810                                                           17    2528
XP_006722325                                                           17    2528
NP_001135797                                                           17    3301
NP_001135796                                                           17    3301
NP_003044                                                              17    3301
NP_001129163                                                           17    3301
NP_065770                                                              17    3301
NP_001167569                                                           17    4312
NP_060814                                                              17    4312
XP_006717973                                                           17    4312
NP_054860                                                              16    5631
NP_006246                                                              16    7355
NP_001265596                                                           16    7355
NP_057361                                                              16    7355
NP_899050                                                              16    7355
NP_001265597                                                           16    7355
NP_001265595                                                           16    7355
NP_008969                                                              15    9605
NP_001276005                                                           15    9605
NP_001276008                                                           15    9605
NP_001029030                                                           15    9605
NP_071932                                                              15    9605
NP_001276006                                                           15    9605
NP_001029029                                                           15    9605
NP_001029027                                                           15    9605
NP_001276007                                                           15    9605
NP_001244210                                                           15    9605
NP_689596                                                              15    9605
NP_079467                                                              15    9605
XP_005252615                                                           15    9605
XP_006717554                                                           15    9605
XP_005245556                                                           15    9605
>NP_722576
          Length = 3080

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SSNRVGVHI 9
            SSN VGVHI
Sbjct: 1345 SSNTVGVHI 1353
>XP_005262424
          Length = 2875

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SSNRVGVHI 9
            SSN VGVHI
Sbjct: 1140 SSNTVGVHI 1148
>NP_001138537
          Length = 900

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  SSNRVGVH 8
          SSN VGVH
Sbjct: 35 SSNTVGVH 42
>NP_997374
          Length = 677

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  SSNRVGVH 8
          SSN VGVH
Sbjct: 35 SSNTVGVH 42
>XP_006726821
          Length = 408

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  SSNRVGVHI 9
          +S+R+GVH+
Sbjct: 38 TSSRLGVHV 46
>XP_006726817
          Length = 477

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  SSNRVGVHI 9
          +S+R+GVH+
Sbjct: 38 TSSRLGVHV 46
>XP_006726816
          Length = 477

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  SSNRVGVHI 9
          +S+R+GVH+
Sbjct: 38 TSSRLGVHV 46
>XP_006726811
          Length = 499

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  SSNRVGVHI 9
          +S+R+GVH+
Sbjct: 38 TSSRLGVHV 46
>XP_006726810
          Length = 499

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  SSNRVGVHI 9
          +S+R+GVH+
Sbjct: 38 TSSRLGVHV 46
>XP_006722325
          Length = 408

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  SSNRVGVHI 9
          +S+R+GVH+
Sbjct: 38 TSSRLGVHV 46
>NP_001135797
          Length = 472

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SNRVGVHI 9
           +NR+G HI
Sbjct: 161 TNRIGYHI 168
>NP_001135796
          Length = 493

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SNRVGVHI 9
           +NR+G HI
Sbjct: 161 TNRIGYHI 168
>NP_003044
          Length = 525

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SNRVGVHI 9
           +NR+G HI
Sbjct: 161 TNRIGYHI 168
>NP_001129163
          Length = 525

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SNRVGVHI 9
           +NR+G HI
Sbjct: 161 TNRIGYHI 168
>NP_065770
          Length = 2036

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SSNRVGVHI 9
           S+++VGVH+
Sbjct: 815 SASKVGVHL 823
>NP_001167569
          Length = 258

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   NRVGVHI 9
           NRV VHI
Sbjct: 127 NRVAVHI 133
>NP_060814
          Length = 475

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   NRVGVHI 9
           NRV VHI
Sbjct: 127 NRVAVHI 133
>XP_006717973
          Length = 397

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  NRVGVHI 9
          NRV VHI
Sbjct: 49 NRVAVHI 55
>NP_054860
          Length = 1331

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SSNRVGVHI 9
           + ++VGVHI
Sbjct: 427 TESKVGVHI 435
>NP_006246
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SSNRVGV 7
           SSNR+G+
Sbjct: 346 SSNRLGI 352
>NP_001265596
          Length = 237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SSNRVGV 7
           SSN++GV
Sbjct: 187 SSNKIGV 193
>NP_057361
          Length = 237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SSNRVGV 7
           SSN++GV
Sbjct: 187 SSNKIGV 193
>NP_899050
          Length = 237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SSNRVGV 7
           SSN++GV
Sbjct: 187 SSNKIGV 193
>NP_001265597
          Length = 237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SSNRVGV 7
           SSN++GV
Sbjct: 187 SSNKIGV 193
>NP_001265595
          Length = 237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SSNRVGV 7
           SSN++GV
Sbjct: 187 SSNKIGV 193
>NP_008969
          Length = 930

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SNRVGVH 8
           SN+VG H
Sbjct: 867 SNKVGSH 873
>NP_001276005
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SSNRVGVHI 9
           S NR+ +HI
Sbjct: 161 SRNRIPLHI 169
>NP_001276008
          Length = 572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SSNRVGVHI 9
           S NR+ +HI
Sbjct: 156 SRNRIPLHI 164
>NP_001029030
          Length = 572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SSNRVGVHI 9
           S NR+ +HI
Sbjct: 156 SRNRIPLHI 164
>NP_071932
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SSNRVGVHI 9
           S NR+ +HI
Sbjct: 161 SRNRIPLHI 169
>NP_001276006
          Length = 572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SSNRVGVHI 9
           S NR+ +HI
Sbjct: 156 SRNRIPLHI 164
>NP_001029029
          Length = 572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SSNRVGVHI 9
           S NR+ +HI
Sbjct: 156 SRNRIPLHI 164
>NP_001029027
          Length = 692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SSNRVGVHI 9
           S NR+ +HI
Sbjct: 276 SRNRIPLHI 284
>NP_001276007
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SSNRVGVHI 9
           S NR+ +HI
Sbjct: 161 SRNRIPLHI 169
>NP_001244210
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RVGVHI 9
           +VGVHI
Sbjct: 405 KVGVHI 410
>NP_689596
          Length = 885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RVGVHI 9
           +VGVHI
Sbjct: 405 KVGVHI 410
>NP_079467
          Length = 932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SSNRVGVHI 9
           SSN VGV I
Sbjct: 266 SSNLVGVTI 274
>XP_005252615
          Length = 572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SSNRVGVHI 9
           S NR+ +HI
Sbjct: 156 SRNRIPLHI 164
>XP_006717554
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SSNRVGVHI 9
           S NR+ +HI
Sbjct: 161 SRNRIPLHI 169
>XP_005245556
          Length = 933

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SSNRVGVHI 9
           SSN VGV I
Sbjct: 266 SSNLVGVTI 274
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.130    0.361 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 490,818
Number of extensions: 805
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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