Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              22     103
XP_005271621                                                           22     103
XP_006718907                                                           22     103
XP_006718906                                                           22     103
XP_005271619                                                           22     103
XP_005271618                                                           22     103
NP_004708                                                              17    3301
XP_006716236                                                           17    3301
XP_006716235                                                           17    3301
NP_001278327                                                           17    4312
NP_001005751                                                           17    4312
NP_001162578                                                           17    4312
XP_006717895                                                           17    4312
XP_005269865                                                           17    4312
XP_006717894                                                           17    4312
XP_005269864                                                           17    4312
XP_005269863                                                           17    4312
NP_001162577                                                           17    4312
NP_056077                                                              17    4312
NP_037513                                                              16    5631
NP_002323                                                              16    7355
NP_446464                                                              16    7355
NP_001002814                                                           16    7355
NP_000041                                                              16    7355
NP_079427                                                              16    7355
XP_006718581                                                           16    7355
XP_005273986                                                           16    7355
XP_006718580                                                           16    7355
XP_005273985                                                           16    7355
XP_005273983                                                           16    7355
XP_006718579                                                           16    7355
XP_005273982                                                           16    7355
XP_005272257                                                           16    7355
XP_005272256                                                           16    7355
NP_001025030                                                           16    7355
NP_008995                                                              15    9605
NP_001019831                                                           15    9605
NP_066012                                                              15    9605
NP_001018098                                                           15    9605
NP_060154                                                              15    9605
NP_060550                                                              15    9605
NP_065872                                                              15    9605
NP_056150                                                              15    9605
NP_001036171                                                           15    9605
NP_001036170                                                           15    9605
NP_115598                                                              15    9605
NP_001184043                                                           15    9605
NP_001184042                                                           15    9605
XP_006719370                                                           15    9605
XP_006719369                                                           15    9605
XP_006719368                                                           15    9605
XP_005267190                                                           15    9605
XP_005267189                                                           15    9605
XP_005267187                                                           15    9605
XP_005267185                                                           15    9605
XP_005267184                                                           15    9605
XP_005263223                                                           15    9605
XP_006714268                                                           15    9605
XP_006714266                                                           15    9605
XP_006714265                                                           15    9605
XP_006714264                                                           15    9605
XP_006714263                                                           15    9605
XP_006714262                                                           15    9605
XP_006713877                                                           15    9605
XP_006713876                                                           15    9605
XP_006713875                                                           15    9605
XP_006713874                                                           15    9605
XP_006713873                                                           15    9605
NP_001184029                                                           15    9605
NP_009055                                                              15    9605
>NP_000042
          Length = 3056

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SSMNVFNDY 9
           SSMN+FNDY
Sbjct: 853 SSMNLFNDY 861
>XP_005271621
          Length = 2708

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SSMNVFNDY 9
           SSMN+FNDY
Sbjct: 505 SSMNLFNDY 513
>XP_006718907
          Length = 3050

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SSMNVFNDY 9
           SSMN+FNDY
Sbjct: 853 SSMNLFNDY 861
>XP_006718906
          Length = 3056

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SSMNVFNDY 9
           SSMN+FNDY
Sbjct: 853 SSMNLFNDY 861
>XP_005271619
          Length = 3056

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SSMNVFNDY 9
           SSMN+FNDY
Sbjct: 853 SSMNLFNDY 861
>XP_005271618
          Length = 3056

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SSMNVFNDY 9
           SSMN+FNDY
Sbjct: 853 SSMNLFNDY 861
>NP_004708
          Length = 1065

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MNVFNDY 9
           +NVFN+Y
Sbjct: 524 LNVFNNY 530
>XP_006716236
          Length = 1022

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MNVFNDY 9
           +NVFN+Y
Sbjct: 489 LNVFNNY 495
>XP_006716235
          Length = 1057

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MNVFNDY 9
           +NVFN+Y
Sbjct: 524 LNVFNNY 530
>NP_001278327
          Length = 1320

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NVFNDY 9
          NVFND+
Sbjct: 81 NVFNDF 86
>NP_001005751
          Length = 1341

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NVFNDY 9
          NVFND+
Sbjct: 81 NVFNDF 86
>NP_001162578
          Length = 1245

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NVFNDY 9
          NVFND+
Sbjct: 81 NVFNDF 86
>XP_006717895
          Length = 1297

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NVFNDY 9
           NVFND+
Sbjct: 133 NVFNDF 138
>XP_005269865
          Length = 1331

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NVFNDY 9
           NVFND+
Sbjct: 133 NVFNDF 138
>XP_006717894
          Length = 1342

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NVFNDY 9
           NVFND+
Sbjct: 133 NVFNDF 138
>XP_005269864
          Length = 1364

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NVFNDY 9
           NVFND+
Sbjct: 133 NVFNDF 138
>XP_005269863
          Length = 1369

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NVFNDY 9
           NVFND+
Sbjct: 133 NVFNDF 138
>NP_001162577
          Length = 1279

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NVFNDY 9
          NVFND+
Sbjct: 81 NVFNDF 86
>NP_056077
          Length = 1320

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NVFNDY 9
          NVFND+
Sbjct: 81 NVFNDF 86
>NP_037513
          Length = 1024

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   NVFNDY 9
           N+FN+Y
Sbjct: 775 NIFNEY 780
>NP_002323
          Length = 4544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SMNVFNDY 9
            S++VF DY
Sbjct: 4094 SIDVFEDY 4101
>NP_446464
          Length = 412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SMNVFNDY 9
           SMNV  DY
Sbjct: 376 SMNVQGDY 383
>NP_001002814
          Length = 1283

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SSMNVFND 8
           SS+N+F D
Sbjct: 500 SSLNLFED 507
>NP_000041
          Length = 412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SMNVFNDY 9
           SMNV  DY
Sbjct: 376 SMNVQGDY 383
>NP_079427
          Length = 649

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SSMNVFND 8
           SS+N+F D
Sbjct: 500 SSLNLFED 507
>XP_006718581
          Length = 260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SSMNVFN 7
           SSM VFN
Sbjct: 139 SSMEVFN 145
>XP_005273986
          Length = 260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SSMNVFN 7
           SSM VFN
Sbjct: 139 SSMEVFN 145
>XP_006718580
          Length = 260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SSMNVFN 7
           SSM VFN
Sbjct: 139 SSMEVFN 145
>XP_005273985
          Length = 260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SSMNVFN 7
           SSM VFN
Sbjct: 139 SSMEVFN 145
>XP_005273983
          Length = 277

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SSMNVFN 7
           SSM VFN
Sbjct: 156 SSMEVFN 162
>XP_006718579
          Length = 296

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SSMNVFN 7
           SSM VFN
Sbjct: 175 SSMEVFN 181
>XP_005273982
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SSMNVFN 7
           SSM VFN
Sbjct: 208 SSMEVFN 214
>XP_005272257
          Length = 412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SMNVFNDY 9
           SMNV  DY
Sbjct: 376 SMNVQGDY 383
>XP_005272256
          Length = 444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SMNVFNDY 9
           SMNV  DY
Sbjct: 408 SMNVQGDY 415
>NP_001025030
          Length = 260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SSMNVFN 7
           SSM VFN
Sbjct: 139 SSMEVFN 145
>NP_008995
          Length = 1289

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   SSMNVFNDY 9
           SSM V  DY
Sbjct: 627 SSMAVIKDY 635
>NP_001019831
          Length = 2986

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    SSMNVFNDY 9
            SSM V  DY
Sbjct: 2324 SSMAVIKDY 2332
>NP_066012
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   SMNVFNDY 9
           S+N  NDY
Sbjct: 112 SLNPHNDY 119
>NP_001018098
          Length = 3628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SSMNVFND 8
            S +NVFN+
Sbjct: 2394 SCLNVFNN 2401
>NP_060154
          Length = 3710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SSMNVFND 8
            S +NVFN+
Sbjct: 2351 SCLNVFNN 2358
>NP_060550
          Length = 3585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SSMNVFND 8
            S +NVFN+
Sbjct: 2351 SCLNVFNN 2358
>NP_065872
          Length = 3753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SSMNVFND 8
            S +NVFN+
Sbjct: 2394 SCLNVFNN 2401
>NP_056150
          Length = 2210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    SSMNVFND 8
            S MN+F D
Sbjct: 1118 SVMNIFKD 1125
>NP_001036171
          Length = 112

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  SMNVFND 8
          SMN F+D
Sbjct: 87 SMNTFSD 93
>NP_001036170
          Length = 159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  SMNVFND 8
          SMN F+D
Sbjct: 87 SMNTFSD 93
>NP_115598
          Length = 757

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   NVFND 8
           NVFND
Sbjct: 617 NVFND 621
>NP_001184043
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  SMNVFND 8
          SMN F+D
Sbjct: 60 SMNTFSD 66
>NP_001184042
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  SMNVFND 8
          SMN F+D
Sbjct: 87 SMNTFSD 93
>XP_006719370
          Length = 2076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SSMNVFND 8
           S MN+F D
Sbjct: 984 SVMNIFKD 991
>XP_006719369
          Length = 2200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    SSMNVFND 8
            S MN+F D
Sbjct: 1108 SVMNIFKD 1115
>XP_006719368
          Length = 2209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    SSMNVFND 8
            S MN+F D
Sbjct: 1117 SVMNIFKD 1124
>XP_005267190
          Length = 3424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SMNVFND 8
           S+NV ND
Sbjct: 924 SLNVLND 930
>XP_005267189
          Length = 3425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SMNVFND 8
           S+NV ND
Sbjct: 938 SLNVLND 944
>XP_005267187
          Length = 3433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SMNVFND 8
           S+NV ND
Sbjct: 933 SLNVLND 939
>XP_005267185
          Length = 3437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SMNVFND 8
           S+NV ND
Sbjct: 937 SLNVLND 943
>XP_005267184
          Length = 3438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SMNVFND 8
           S+NV ND
Sbjct: 938 SLNVLND 944
>XP_005263223
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   SMNVFNDY 9
           S+N  NDY
Sbjct: 112 SLNPHNDY 119
>XP_006714268
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4    NVFND 8
            NVFND
Sbjct: 1040 NVFND 1044
>XP_006714266
          Length = 1125

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4    NVFND 8
            NVFND
Sbjct: 1087 NVFND 1091
>XP_006714265
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4    NVFND 8
            NVFND
Sbjct: 1091 NVFND 1095
>XP_006714264
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4    NVFND 8
            NVFND
Sbjct: 1091 NVFND 1095
>XP_006714263
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4    NVFND 8
            NVFND
Sbjct: 1091 NVFND 1095
>XP_006714262
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4    NVFND 8
            NVFND
Sbjct: 1091 NVFND 1095
>XP_006713877
          Length = 2956

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    SSMNVFNDY 9
            SSM V  DY
Sbjct: 2294 SSMAVIKDY 2302
>XP_006713876
          Length = 2966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    SSMNVFNDY 9
            SSM V  DY
Sbjct: 2304 SSMAVIKDY 2312
>XP_006713875
          Length = 2975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    SSMNVFNDY 9
            SSM V  DY
Sbjct: 2313 SSMAVIKDY 2321
>XP_006713874
          Length = 2979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    SSMNVFNDY 9
            SSM V  DY
Sbjct: 2317 SSMAVIKDY 2325
>XP_006713873
          Length = 2988

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    SSMNVFNDY 9
            SSM V  DY
Sbjct: 2326 SSMAVIKDY 2334
>NP_001184029
          Length = 132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  SMNVFND 8
          SMN F+D
Sbjct: 60 SMNTFSD 66
>NP_009055
          Length = 3433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SMNVFND 8
           S+NV ND
Sbjct: 933 SLNVLND 939
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.125    0.354 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 411,232
Number of extensions: 667
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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