Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_775656                                                              17    3301
NP_002596                                                              17    3301
NP_001230066                                                           17    3301
XP_006720631                                                           17    3301
XP_006720630                                                           17    3301
XP_005254990                                                           17    3301
NP_001093260                                                           17    4312
NP_001094101                                                           17    4312
NP_055889                                                              16    5631
NP_036466                                                              16    5631
NP_055496                                                              16    5631
NP_001133                                                              16    5631
NP_001134                                                              16    5631
XP_005259500                                                           16    5631
XP_006714538                                                           16    5631
NP_060903                                                              16    7355
NP_001140160                                                           16    7355
NP_689997                                                              16    7355
NP_001275728                                                           16    7355
NP_001087236                                                           16    7355
NP_065171                                                              16    7355
NP_997251                                                              16    7355
NP_065202                                                              16    7355
NP_001275727                                                           16    7355
XP_006725017                                                           16    7355
XP_006712114                                                           16    7355
XP_006711144                                                           16    7355
NP_001025031                                                           16    7355
NP_001185797                                                           15    9605
NP_005177                                                              15    9605
NP_001185798                                                           15    9605
NP_775771                                                              15    9605
NP_665739                                                              15    9605
NP_997054                                                              15    9605
NP_001181866                                                           15    9605
NP_055915                                                              15    9605
NP_001181867                                                           15    9605
NP_001229658                                                           15    9605
NP_001158238                                                           15    9605
NP_055754                                                              15    9605
NP_008816                                                              15    9605
XP_003960128                                                           15    9605
XP_005258292                                                           15    9605
XP_006722483                                                           15    9605
XP_005258291                                                           15    9605
XP_005258290                                                           15    9605
XP_005256014                                                           15    9605
XP_006720466                                                           15    9605
XP_005254230                                                           15    9605
XP_006720465                                                           15    9605
XP_005254228                                                           15    9605
XP_006718761                                                           15    9605
XP_006717822                                                           15    9605
XP_006717821                                                           15    9605
XP_005269749                                                           15    9605
XP_006717820                                                           15    9605
XP_006714307                                                           15    9605
XP_006711300                                                           15    9605
XP_005245063                                                           15    9605
XP_005245062                                                           15    9605
XP_005245061                                                           15    9605
XP_005245060                                                           15    9605
XP_005245057                                                           15    9605
XP_005245058                                                           15    9605
XP_005245056                                                           15    9605
NP_065081                                                              15    9605
NP_954980                                                              15    9605
>NP_775656
          Length = 783

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSEILTPLS 9
           SS I+TP+S
Sbjct: 426 SSNIITPIS 434
>NP_002596
          Length = 829

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSEILTPLS 9
           SS I+TP+S
Sbjct: 472 SSNIITPIS 480
>NP_001230066
          Length = 757

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSEILTPLS 9
           SS I+TP+S
Sbjct: 400 SSNIITPIS 408
>XP_006720631
          Length = 582

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSEILTPLS 9
           SS I+TP+S
Sbjct: 472 SSNIITPIS 480
>XP_006720630
          Length = 582

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSEILTPLS 9
           SS I+TP+S
Sbjct: 225 SSNIITPIS 233
>XP_005254990
          Length = 639

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSEILTPLS 9
           SS I+TP+S
Sbjct: 282 SSNIITPIS 290
>NP_001093260
          Length = 479

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SEILTPL 8
           SE+LTPL
Sbjct: 427 SELLTPL 433
>NP_001094101
          Length = 481

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SEILTPL 8
           SE+LTPL
Sbjct: 429 SELLTPL 435
>NP_055889
          Length = 1770

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SSEILTP 7
            SSE++TP
Sbjct: 1024 SSEVITP 1030
>NP_036466
          Length = 2058

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EILTPLS 9
           EILTPL+
Sbjct: 384 EILTPLN 390
>NP_055496
          Length = 1143

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SSEILTPL 8
           SSE LTP+
Sbjct: 569 SSEALTPI 576
>NP_001133
          Length = 191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SSEILTPL 8
          S E+LTPL
Sbjct: 32 SYEVLTPL 39
>NP_001134
          Length = 192

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SSEILTPL 8
          S E+LTPL
Sbjct: 32 SYEVLTPL 39
>XP_005259500
          Length = 1143

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SSEILTPL 8
           SSE LTP+
Sbjct: 569 SSEALTPI 576
>XP_006714538
          Length = 2035

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EILTPLS 9
           EILTPL+
Sbjct: 384 EILTPLN 390
>NP_060903
          Length = 1321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSEILTPLS 9
           +S ILTP+S
Sbjct: 870 NSTILTPVS 878
>NP_001140160
          Length = 1321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSEILTPLS 9
           +S ILTP+S
Sbjct: 870 NSTILTPVS 878
>NP_689997
          Length = 798

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   EILTPL 8
           EILTPL
Sbjct: 351 EILTPL 356
>NP_001275728
          Length = 63

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  SSEILTP 7
          SSEI TP
Sbjct: 25 SSEIFTP 31
>NP_001087236
          Length = 97

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  SSEILTP 7
          SSEI TP
Sbjct: 25 SSEIFTP 31
>NP_065171
          Length = 238

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SSEILTPL 8
           + E+LTPL
Sbjct: 183 TQEVLTPL 190
>NP_997251
          Length = 97

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  SSEILTP 7
          SSEI TP
Sbjct: 25 SSEIFTP 31
>NP_065202
          Length = 354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   EILTPL 8
           EILTPL
Sbjct: 223 EILTPL 228
>NP_001275727
          Length = 118

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  SSEILTP 7
          SSEI TP
Sbjct: 46 SSEIFTP 52
>XP_006725017
          Length = 229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   EILTPL 8
           EILTPL
Sbjct: 183 EILTPL 188
>XP_006712114
          Length = 661

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SSEILTPLS 9
           +S ILTP+S
Sbjct: 210 NSTILTPVS 218
>XP_006711144
          Length = 229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   EILTPL 8
           EILTPL
Sbjct: 183 EILTPL 188
>NP_001025031
          Length = 708

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EILTPLS 9
           E+LTPL+
Sbjct: 604 EVLTPLA 610
>NP_001185797
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1 SSEILTPL 8
         S EI+TP+
Sbjct: 2 SEEIITPV 9
>NP_005177
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1 SSEILTPL 8
         S EI+TP+
Sbjct: 2 SEEIITPV 9
>NP_001185798
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1 SSEILTPL 8
         S EI+TP+
Sbjct: 2 SEEIITPV 9
>NP_775771
          Length = 1244

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    EILTPLS 9
            E+LTP S
Sbjct: 1018 EVLTPFS 1024
>NP_665739
          Length = 1315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EILTPLS 9
           E+LTPL+
Sbjct: 804 ELLTPLA 810
>NP_997054
          Length = 1357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EILTPLS 9
           E+LTPL+
Sbjct: 846 ELLTPLA 852
>NP_001181866
          Length = 1401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EILTPLS 9
           E+LTPL+
Sbjct: 890 ELLTPLA 896
>NP_055915
          Length = 1410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EILTPLS 9
           E+LTPL+
Sbjct: 899 ELLTPLA 905
>NP_001181867
          Length = 1348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EILTPLS 9
           E+LTPL+
Sbjct: 837 ELLTPLA 843
>NP_001229658
          Length = 777

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ILTPLS 9
           ILTPLS
Sbjct: 419 ILTPLS 424
>NP_001158238
          Length = 2789

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    EILTPLS 9
            EILTP S
Sbjct: 1459 EILTPTS 1465
>NP_055754
          Length = 1435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SSEILTPLS 9
           ++ +LTPLS
Sbjct: 963 NTAVLTPLS 971
>NP_008816
          Length = 3703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    EILTPLS 9
            EILTP S
Sbjct: 2373 EILTPTS 2379
>XP_003960128
          Length = 160

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SSEILTPLS 9
          SSE ++PLS
Sbjct: 50 SSESVSPLS 58
>XP_005258292
          Length = 1161

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SSEILTPLS 9
           ++ +LTPLS
Sbjct: 689 NTAVLTPLS 697
>XP_006722483
          Length = 1338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SSEILTPLS 9
           ++ +LTPLS
Sbjct: 964 NTAVLTPLS 972
>XP_005258291
          Length = 1406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SSEILTPLS 9
           ++ +LTPLS
Sbjct: 964 NTAVLTPLS 972
>XP_005258290
          Length = 1436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SSEILTPLS 9
           ++ +LTPLS
Sbjct: 964 NTAVLTPLS 972
>XP_005256014
          Length = 3702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    EILTPLS 9
            EILTP S
Sbjct: 2372 EILTPTS 2378
>XP_006720466
          Length = 1175

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   EILTPLS 9
           E+LTP S
Sbjct: 949 EVLTPFS 955
>XP_005254230
          Length = 1175

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   EILTPLS 9
           E+LTP S
Sbjct: 949 EVLTPFS 955
>XP_006720465
          Length = 1239

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    EILTPLS 9
            E+LTP S
Sbjct: 1013 EVLTPFS 1019
>XP_005254228
          Length = 1250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    EILTPLS 9
            E+LTP S
Sbjct: 1024 EVLTPFS 1030
>XP_006718761
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1 SSEILTPL 8
         S EI+TP+
Sbjct: 2 SEEIITPV 9
>XP_006717822
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EILTPL 8
           E+LTPL
Sbjct: 431 EVLTPL 436
>XP_006717821
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EILTPL 8
           E+LTPL
Sbjct: 431 EVLTPL 436
>XP_005269749
          Length = 901

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EILTPL 8
           E+LTPL
Sbjct: 431 EVLTPL 436
>XP_006717820
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EILTPL 8
           E+LTPL
Sbjct: 431 EVLTPL 436
>XP_006714307
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ILTPLS 9
           ILTPLS
Sbjct: 201 ILTPLS 206
>XP_006711300
          Length = 1348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EILTPLS 9
           E+LTPL+
Sbjct: 837 ELLTPLA 843
>XP_005245063
          Length = 1357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EILTPLS 9
           E+LTPL+
Sbjct: 846 ELLTPLA 852
>XP_005245062
          Length = 1357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EILTPLS 9
           E+LTPL+
Sbjct: 846 ELLTPLA 852
>XP_005245061
          Length = 1357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EILTPLS 9
           E+LTPL+
Sbjct: 846 ELLTPLA 852
>XP_005245060
          Length = 1401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EILTPLS 9
           E+LTPL+
Sbjct: 890 ELLTPLA 896
>XP_005245057
          Length = 1410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EILTPLS 9
           E+LTPL+
Sbjct: 899 ELLTPLA 905
>XP_005245058
          Length = 1410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EILTPLS 9
           E+LTPL+
Sbjct: 899 ELLTPLA 905
>XP_005245056
          Length = 1410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EILTPLS 9
           E+LTPL+
Sbjct: 899 ELLTPLA 905
>NP_065081
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EILTPL 8
           E+LTPL
Sbjct: 431 EVLTPL 436
>NP_954980
          Length = 159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SSEILTPLS 9
          SSE ++PLS
Sbjct: 49 SSESVSPLS 57
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.297    0.117    0.279 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 649,167
Number of extensions: 1206
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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