Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              18    1482
NP_671714                                                              18    1482
XP_006715890                                                           18    1482
XP_005250160                                                           18    1482
XP_005250159                                                           18    1482
NP_001159579                                                           18    1935
NP_005509                                                              18    1935
NP_001254772                                                           17    4312
NP_001257903                                                           17    4312
NP_004889                                                              17    4312
NP_001137448                                                           17    4312
NP_003381                                                              17    4312
NP_002509                                                              17    4312
XP_006721269                                                           17    4312
XP_005253176                                                           17    4312
XP_005253175                                                           17    4312
XP_006714117                                                           17    4312
XP_005265844                                                           17    4312
XP_005264017                                                           17    4312
XP_005264016                                                           17    4312
XP_005264015                                                           17    4312
XP_005264014                                                           17    4312
XP_005264012                                                           17    4312
XP_005264011                                                           17    4312
XP_005264010                                                           17    4312
NP_055415                                                              16    5631
NP_006786                                                              16    5631
NP_001269373                                                           16    5631
NP_001615                                                              16    5631
NP_001269374                                                           16    5631
XP_006718487                                                           16    5631
XP_005266896                                                           16    5631
NP_940931                                                              16    7355
NP_001138525                                                           16    7355
XP_006721944                                                           16    7355
XP_006721943                                                           16    7355
XP_006721942                                                           16    7355
XP_006718995                                                           16    7355
XP_005274425                                                           16    7355
XP_006718994                                                           16    7355
XP_006718993                                                           16    7355
XP_005274424                                                           16    7355
XP_005274423                                                           16    7355
NP_203753                                                              16    7355
NP_000161                                                              15    9605
NP_036325                                                              15    9605
NP_001240628                                                           15    9605
NP_872198                                                              15    9605
NP_004746                                                              15    9605
NP_862820                                                              15    9605
NP_001184188                                                           15    9605
NP_036513                                                              15    9605
NP_001240630                                                           15    9605
NP_001006600                                                           15    9605
NP_061165                                                              15    9605
NP_001240627                                                           15    9605
NP_001240626                                                           15    9605
XP_005248763                                                           15    9605
XP_005248762                                                           15    9605
XP_005248761                                                           15    9605
XP_006714723                                                           15    9605
XP_005248613                                                           15    9605
XP_005248612                                                           15    9605
XP_005248611                                                           15    9605
>NP_005742
          Length = 3907

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SSEEFTEII 9
            SSEE TEII
Sbjct: 2813 SSEEVTEII 2821
>NP_671714
          Length = 3899

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SSEEFTEII 9
            SSEE TEII
Sbjct: 2805 SSEEVTEII 2813
>XP_006715890
          Length = 3860

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SSEEFTEII 9
            SSEE TEII
Sbjct: 2766 SSEEVTEII 2774
>XP_005250160
          Length = 3939

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SSEEFTEII 9
            SSEE TEII
Sbjct: 2845 SSEEVTEII 2853
>XP_005250159
          Length = 3952

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SSEEFTEII 9
            SSEE TEII
Sbjct: 2858 SSEEVTEII 2866
>NP_001159579
          Length = 466

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SSEEFTEII 9
           S EEFTEI+
Sbjct: 414 SPEEFTEIM 422
>NP_005509
          Length = 508

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SSEEFTEII 9
           S EEFTEI+
Sbjct: 456 SPEEFTEIM 464
>NP_001254772
          Length = 846

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SSEEFTEII 9
           S+EEFT+++
Sbjct: 106 SNEEFTQLM 114
>NP_001257903
          Length = 5121

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    SSEEFTEII 9
            S  EFTEII
Sbjct: 3631 SISEFTEII 3639
>NP_004889
          Length = 846

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SSEEFTEII 9
           S+EEFT+++
Sbjct: 106 SNEEFTQLM 114
>NP_001137448
          Length = 432

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEEFTEII 9
           S+EFTE++
Sbjct: 325 SQEFTELL 332
>NP_003381
          Length = 646

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEEFTEII 9
           S+EFTE++
Sbjct: 539 SQEFTELL 546
>NP_002509
          Length = 824

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  SSEEFTEII 9
          S+EEFT+++
Sbjct: 81 SNEEFTQLM 89
>XP_006721269
          Length = 5138

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    SSEEFTEII 9
            S  EFTEII
Sbjct: 3648 SISEFTEII 3656
>XP_005253176
          Length = 433

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEEFTEII 9
           S+EFTE++
Sbjct: 325 SQEFTELL 332
>XP_005253175
          Length = 647

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEEFTEII 9
           S+EFTE++
Sbjct: 539 SQEFTELL 546
>XP_006714117
          Length = 846

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SSEEFTEII 9
           S+EEFT+++
Sbjct: 106 SNEEFTQLM 114
>XP_005265844
          Length = 846

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SSEEFTEII 9
           S+EEFT+++
Sbjct: 106 SNEEFTQLM 114
>XP_005264017
          Length = 786

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SSEEFTEII 9
           S+EEFT+++
Sbjct: 146 SNEEFTQLM 154
>XP_005264016
          Length = 835

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SSEEFTEII 9
           S+EEFT+++
Sbjct: 146 SNEEFTQLM 154
>XP_005264015
          Length = 838

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SSEEFTEII 9
           S+EEFT+++
Sbjct: 95  SNEEFTQLM 103
>XP_005264014
          Length = 851

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SSEEFTEII 9
           S+EEFT+++
Sbjct: 146 SNEEFTQLM 154
>XP_005264012
          Length = 854

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SSEEFTEII 9
           S+EEFT+++
Sbjct: 111 SNEEFTQLM 119
>XP_005264011
          Length = 888

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SSEEFTEII 9
           S+EEFT+++
Sbjct: 146 SNEEFTQLM 154
>XP_005264010
          Length = 889

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SSEEFTEII 9
           S+EEFT+++
Sbjct: 146 SNEEFTQLM 154
>NP_055415
          Length = 535

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEEFTEII 9
           S+EF+E+I
Sbjct: 197 SDEFSEVI 204
>NP_006786
          Length = 534

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEEFTEII 9
           S+EF+E+I
Sbjct: 197 SDEFSEVI 204
>NP_001269373
          Length = 534

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEEFTEII 9
           S+EF+E+I
Sbjct: 197 SDEFSEVI 204
>NP_001615
          Length = 1723

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EEFTEII 9
           E+FTEII
Sbjct: 698 EKFTEII 704
>NP_001269374
          Length = 548

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEEFTEII 9
           S+EF+E+I
Sbjct: 211 SDEFSEVI 218
>XP_006718487
          Length = 534

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEEFTEII 9
           S+EF+E+I
Sbjct: 197 SDEFSEVI 204
>XP_005266896
          Length = 2131

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    EEFTEII 9
            E+FTEII
Sbjct: 1106 EKFTEII 1112
>NP_940931
          Length = 1503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SSEEFTEII 9
           S++EF E+I
Sbjct: 372 SADEFREVI 380
>NP_001138525
          Length = 856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SSEEFTEII 9
           S++EF E+I
Sbjct: 316 SADEFREVI 324
>XP_006721944
          Length = 1232

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SSEEFTEII 9
           S++EF E+I
Sbjct: 372 SADEFREVI 380
>XP_006721943
          Length = 1456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SSEEFTEII 9
           S++EF E+I
Sbjct: 372 SADEFREVI 380
>XP_006721942
          Length = 1503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SSEEFTEII 9
           S++EF E+I
Sbjct: 372 SADEFREVI 380
>XP_006718995
          Length = 2382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SEEFTEII 9
            SEE TEI+
Sbjct: 1992 SEEHTEIL 1999
>XP_005274425
          Length = 2566

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SEEFTEII 9
            SEE TEI+
Sbjct: 2177 SEEHTEIL 2184
>XP_006718994
          Length = 2567

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SEEFTEII 9
            SEE TEI+
Sbjct: 2177 SEEHTEIL 2184
>XP_006718993
          Length = 2602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SEEFTEII 9
            SEE TEI+
Sbjct: 2212 SEEHTEIL 2219
>XP_005274424
          Length = 2614

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SEEFTEII 9
            SEE TEI+
Sbjct: 2225 SEEHTEIL 2232
>XP_005274423
          Length = 2615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SEEFTEII 9
            SEE TEI+
Sbjct: 2225 SEEHTEIL 2232
>NP_203753
          Length = 2601

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SEEFTEII 9
            SEE TEI+
Sbjct: 2212 SEEHTEIL 2219
>NP_000161
          Length = 1020

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   EEFTEII 9
           E+FTE++
Sbjct: 274 EDFTELV 280
>NP_036325
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SSEEFTEI 8
           S++EFT+I
Sbjct: 214 SAKEFTDI 221
>NP_001240628
          Length = 1419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SEEFTEI 8
           S EFTE+
Sbjct: 193 SNEFTEV 199
>NP_872198
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SEEFTEI 8
           +EEFTE+
Sbjct: 349 AEEFTEM 355
>NP_004746
          Length = 802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SEEFTEI 8
           +EEFTE+
Sbjct: 349 AEEFTEM 355
>NP_862820
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SSEEFTEII 9
           +SEE  EII
Sbjct: 669 TSEEMNEII 677
>NP_001184188
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SSEEFTEII 9
           +SEE  EII
Sbjct: 525 TSEEMNEII 533
>NP_036513
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SSEEFTEII 9
           +SEE  EII
Sbjct: 668 TSEEMNEII 676
>NP_001240630
          Length = 1367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SEEFTEI 8
           S EFTE+
Sbjct: 193 SNEFTEV 199
>NP_001006600
          Length = 1302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SEEFTEI 8
           S EFTE+
Sbjct: 193 SNEFTEV 199
>NP_061165
          Length = 1371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SEEFTEI 8
           S EFTE+
Sbjct: 193 SNEFTEV 199
>NP_001240627
          Length = 1346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SEEFTEI 8
           S EFTE+
Sbjct: 193 SNEFTEV 199
>NP_001240626
          Length = 1412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SEEFTEI 8
           S EFTE+
Sbjct: 193 SNEFTEV 199
>XP_005248763
          Length = 659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SSEEFTEII 9
           +SEE  EII
Sbjct: 616 TSEEMNEII 624
>XP_005248762
          Length = 659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SSEEFTEII 9
           +SEE  EII
Sbjct: 616 TSEEMNEII 624
>XP_005248761
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SSEEFTEII 9
           +SEE  EII
Sbjct: 669 TSEEMNEII 677
>XP_006714723
          Length = 1246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SEEFTEI 8
           S EFTE+
Sbjct: 193 SNEFTEV 199
>XP_005248613
          Length = 1391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SEEFTEI 8
           S EFTE+
Sbjct: 193 SNEFTEV 199
>XP_005248612
          Length = 1456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SEEFTEI 8
           S EFTE+
Sbjct: 193 SNEFTEV 199
>XP_005248611
          Length = 1460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SEEFTEI 8
           S EFTE+
Sbjct: 193 SNEFTEV 199
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.301    0.122    0.279 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 500,660
Number of extensions: 1038
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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