Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004295                                                              17    2528
NP_001011705                                                           17    4312
NP_008946                                                              17    4312
XP_006719824                                                           17    4312
XP_006719823                                                           17    4312
NP_002221                                                              16    5631
NP_001895                                                              16    5631
NP_001091680                                                           16    5631
NP_068831                                                              16    5631
NP_001091679                                                           16    5631
NP_689777                                                              16    5631
NP_060360                                                              16    5631
XP_006721941                                                           16    5631
XP_006721940                                                           16    5631
XP_006721939                                                           16    5631
XP_006721938                                                           16    5631
XP_006721937                                                           16    5631
XP_006721936                                                           16    5631
XP_006721935                                                           16    5631
XP_006721934                                                           16    5631
XP_005257370                                                           16    5631
XP_006716573                                                           16    5631
XP_005250858                                                           16    5631
XP_005250857                                                           16    5631
XP_006713048                                                           16    5631
XP_006713047                                                           16    5631
XP_006713046                                                           16    5631
XP_005264943                                                           16    5631
NP_996772                                                              16    7355
NP_940927                                                              15    9605
NP_005370                                                              15    9605
NP_000443                                                              15    9605
NP_001242970                                                           15    9605
XP_006720560                                                           15    9605
XP_005254961                                                           15    9605
XP_005254960                                                           15    9605
XP_005254959                                                           15    9605
NP_001004760                                                           15    9605
>NP_004295
          Length = 1620

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           SRVLK GSV
Sbjct: 124 SRVLKGGSV 132
>NP_001011705
          Length = 333

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  SRVLKVGSV 9
          +R+LKVG+V
Sbjct: 37 ARLLKVGAV 45
>NP_008946
          Length = 334

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  SRVLKVGSV 9
          +R+LKVG+V
Sbjct: 37 ARLLKVGAV 45
>XP_006719824
          Length = 217

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  SRVLKVGSV 9
          +R+LKVG+V
Sbjct: 37 ARLLKVGAV 45
>XP_006719823
          Length = 218

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  SRVLKVGSV 9
          +R+LKVG+V
Sbjct: 37 ARLLKVGAV 45
>NP_002221
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           SRVLKV SV
Sbjct: 332 SRVLKVLSV 340
>NP_001895
          Length = 781

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           SRVLKV SV
Sbjct: 341 SRVLKVLSV 349
>NP_001091680
          Length = 781

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           SRVLKV SV
Sbjct: 341 SRVLKVLSV 349
>NP_068831
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           SRVLKV SV
Sbjct: 332 SRVLKVLSV 340
>NP_001091679
          Length = 781

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           SRVLKV SV
Sbjct: 341 SRVLKVLSV 349
>NP_689777
          Length = 3997

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VLKVGSV 9
            VLK+GSV
Sbjct: 1555 VLKIGSV 1561
>NP_060360
          Length = 4022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VLKVGSV 9
            VLK+GSV
Sbjct: 1580 VLKIGSV 1586
>XP_006721941
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           SRVLKV SV
Sbjct: 332 SRVLKVLSV 340
>XP_006721940
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           SRVLKV SV
Sbjct: 332 SRVLKVLSV 340
>XP_006721939
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           SRVLKV SV
Sbjct: 332 SRVLKVLSV 340
>XP_006721938
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           SRVLKV SV
Sbjct: 332 SRVLKVLSV 340
>XP_006721937
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           SRVLKV SV
Sbjct: 332 SRVLKVLSV 340
>XP_006721936
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           SRVLKV SV
Sbjct: 332 SRVLKVLSV 340
>XP_006721935
          Length = 762

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           SRVLKV SV
Sbjct: 349 SRVLKVLSV 357
>XP_006721934
          Length = 783

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           SRVLKV SV
Sbjct: 370 SRVLKVLSV 378
>XP_005257370
          Length = 783

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           SRVLKV SV
Sbjct: 370 SRVLKVLSV 378
>XP_006716573
          Length = 1776

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VLKVGSV 9
            VLK+GSV
Sbjct: 1580 VLKIGSV 1586
>XP_005250858
          Length = 4022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VLKVGSV 9
            VLK+GSV
Sbjct: 1580 VLKIGSV 1586
>XP_005250857
          Length = 4022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VLKVGSV 9
            VLK+GSV
Sbjct: 1580 VLKIGSV 1586
>XP_006713048
          Length = 720

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           SRVLKV SV
Sbjct: 341 SRVLKVLSV 349
>XP_006713047
          Length = 774

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           SRVLKV SV
Sbjct: 334 SRVLKVLSV 342
>XP_006713046
          Length = 774

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           SRVLKV SV
Sbjct: 334 SRVLKVLSV 342
>XP_005264943
          Length = 781

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           SRVLKV SV
Sbjct: 341 SRVLKVLSV 349
>NP_996772
          Length = 889

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SRVLKVGS 8
           SRVL+VG+
Sbjct: 875 SRVLQVGA 882
>NP_940927
          Length = 1343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RVLKVGS 8
           RVLK GS
Sbjct: 258 RVLKTGS 264
>NP_005370
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           S VLK+G+V
Sbjct: 269 SMVLKLGNV 277
>NP_000443
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VLKVGSV 9
           +LK+GS+
Sbjct: 193 ILKIGSI 199
>NP_001242970
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRVLKVGSV 9
           S VLK+G+V
Sbjct: 269 SMVLKLGNV 277
>XP_006720560
          Length = 1313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RVLKVGS 8
           RVLK GS
Sbjct: 258 RVLKTGS 264
>XP_005254961
          Length = 1342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RVLKVGS 8
           RVLK GS
Sbjct: 258 RVLKTGS 264
>XP_005254960
          Length = 1342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RVLKVGS 8
           RVLK GS
Sbjct: 258 RVLKTGS 264
>XP_005254959
          Length = 1343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RVLKVGS 8
           RVLK GS
Sbjct: 258 RVLKTGS 264
>NP_001004760
          Length = 321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   SRVLKVG 7
           SR++K+G
Sbjct: 148 SRIIKIG 154
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.132    0.318 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 366,339
Number of extensions: 364
Number of successful extensions: 38
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package