Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              17    2528
NP_671714                                                              17    2528
XP_006715890                                                           17    2528
XP_005250160                                                           17    2528
XP_005250159                                                           17    2528
NP_115867                                                              16    5631
NP_001186692                                                           16    7355
NP_002837                                                              16    7355
NP_001186693                                                           16    7355
NP_056171                                                              15    9605
NP_874365                                                              15    9605
NP_005520                                                              15    9605
NP_071451                                                              15    9605
XP_006726587                                                           15    9605
XP_006710661                                                           15    9605
XP_005245920                                                           15    9605
XP_006710660                                                           15    9605
XP_006710659                                                           15    9605
XP_006710658                                                           15    9605
XP_006710657                                                           15    9605
XP_006710006                                                           15    9605
>NP_005742
          Length = 3907

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SRVAEGSVS 9
            SR AEGSVS
Sbjct: 1028 SRGAEGSVS 1036
>NP_671714
          Length = 3899

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SRVAEGSVS 9
            SR AEGSVS
Sbjct: 1028 SRGAEGSVS 1036
>XP_006715890
          Length = 3860

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SRVAEGSVS 9
            SR AEGSVS
Sbjct: 1028 SRGAEGSVS 1036
>XP_005250160
          Length = 3939

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SRVAEGSVS 9
            SR AEGSVS
Sbjct: 1028 SRGAEGSVS 1036
>XP_005250159
          Length = 3952

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SRVAEGSVS 9
            SR AEGSVS
Sbjct: 1028 SRGAEGSVS 1036
>NP_115867
          Length = 380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRVAEGSVS 9
           +RVAEG V+
Sbjct: 243 NRVAEGQVT 251
>NP_001186692
          Length = 950

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SRVAEGS 7
           SRV+EGS
Sbjct: 220 SRVSEGS 226
>NP_002837
          Length = 979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SRVAEGS 7
           SRV+EGS
Sbjct: 220 SRVSEGS 226
>NP_001186693
          Length = 889

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SRVAEGS 7
           SRV+EGS
Sbjct: 130 SRVSEGS 136
>NP_056171
          Length = 1630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SRVAEGSVS 9
           SR+AEG  +
Sbjct: 895 SRIAEGGAA 903
>NP_874365
          Length = 1655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SRVAEGSVS 9
           SR+AEG  +
Sbjct: 895 SRIAEGGAA 903
>NP_005520
          Length = 4391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SRVAEG 6
            SRVAEG
Sbjct: 2836 SRVAEG 2841
>NP_071451
          Length = 1025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VAEGSVS 9
           +AEGSVS
Sbjct: 262 LAEGSVS 268
>XP_006726587
          Length = 218

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RVAEGS 7
           RVAEGS
Sbjct: 208 RVAEGS 213
>XP_006710661
          Length = 4057

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SRVAEG 6
            SRVAEG
Sbjct: 3019 SRVAEG 3024
>XP_005245920
          Length = 4392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SRVAEG 6
            SRVAEG
Sbjct: 2837 SRVAEG 2842
>XP_006710660
          Length = 4397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SRVAEG 6
            SRVAEG
Sbjct: 2836 SRVAEG 2841
>XP_006710659
          Length = 4556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SRVAEG 6
            SRVAEG
Sbjct: 2995 SRVAEG 3000
>XP_006710658
          Length = 4563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SRVAEG 6
            SRVAEG
Sbjct: 3002 SRVAEG 3007
>XP_006710657
          Length = 4579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SRVAEG 6
            SRVAEG
Sbjct: 3018 SRVAEG 3023
>XP_006710006
          Length = 218

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RVAEGS 7
           RVAEGS
Sbjct: 208 RVAEGS 213
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.293    0.108    0.245 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 430,092
Number of extensions: 313
Number of successful extensions: 21
Number of sequences better than 10000.0: 21
Number of HSP's gapped: 21
Number of HSP's successfully gapped: 21
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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