Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005148                                                              19     869
NP_009297                                                              19     869
NP_060644                                                              17    3301
NP_058431                                                              17    4312
NP_005197                                                              17    4312
NP_037529                                                              17    4312
NP_001353                                                              16    5631
NP_114404                                                              16    5631
NP_076413                                                              16    5631
XP_006714556                                                           16    5631
XP_006714555                                                           16    5631
NP_001009877                                                           16    5631
NP_002070                                                              16    7355
NP_055641                                                              16    7355
NP_003598                                                              16    7355
XP_005273381                                                           16    7355
XP_005273380                                                           16    7355
XP_005273379                                                           16    7355
XP_006711899                                                           16    7355
XP_005273378                                                           16    7355
XP_005273377                                                           16    7355
XP_006711898                                                           16    7355
XP_006711897                                                           16    7355
XP_005273375                                                           16    7355
XP_005273374                                                           16    7355
NP_001243084                                                           15    9605
NP_065752                                                              15    9605
NP_001186398                                                           15    9605
NP_001184151                                                           15    9605
NP_001159371                                                           15    9605
NP_001184149                                                           15    9605
NP_001184152                                                           15    9605
NP_001184150                                                           15    9605
NP_038476                                                              15    9605
NP_001098101                                                           15    9605
NP_006194                                                              15    9605
NP_001248396                                                           15    9605
NP_872589                                                              15    9605
NP_113627                                                              15    9605
NP_001184147                                                           15    9605
NP_001191819                                                           15    9605
NP_001184148                                                           15    9605
NP_115517                                                              15    9605
XP_005248598                                                           15    9605
XP_005248597                                                           15    9605
XP_005248595                                                           15    9605
XP_005248594                                                           15    9605
NP_078785                                                              15    9605
>NP_005148
          Length = 1130

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRLAIGEEE 9
           SRLA GEEE
Sbjct: 696 SRLATGEEE 704
>NP_009297
          Length = 1149

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SRLAIGEEE 9
           SRLA GEEE
Sbjct: 715 SRLATGEEE 723
>NP_060644
          Length = 1059

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SRLAIGEEE 9
           SRLA GE+E
Sbjct: 346 SRLARGEDE 354
>NP_058431
          Length = 304

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SRLAIGEEE 9
          SRL IG++E
Sbjct: 85 SRLRIGDQE 93
>NP_005197
          Length = 204

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SRLAIGEEE 9
          SRL IG++E
Sbjct: 85 SRLRIGDQE 93
>NP_037529
          Length = 384

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LAIGEEE 9
          LA+GEEE
Sbjct: 85 LALGEEE 91
>NP_001353
          Length = 304

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SRLAIGEEE 9
          SRL +GE E
Sbjct: 7  SRLVVGEGE 15
>NP_114404
          Length = 433

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRLAIGEE 8
           SRLA+G E
Sbjct: 278 SRLALGSE 285
>NP_076413
          Length = 597

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SRLAIGEE 8
           SRL++GE+
Sbjct: 568 SRLSVGEQ 575
>XP_006714556
          Length = 617

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SRLAIGEE 8
           SRL++GE+
Sbjct: 588 SRLSVGEQ 595
>XP_006714555
          Length = 596

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SRLAIGEE 8
           SRL++GE+
Sbjct: 567 SRLSVGEQ 574
>NP_001009877
          Length = 544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SRLAIGEE 8
           SRL++GE+
Sbjct: 515 SRLSVGEQ 522
>NP_002070
          Length = 413

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  SRLAIGEE 8
          SRLA+G++
Sbjct: 85 SRLALGDD 92
>NP_055641
          Length = 1638

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RLAIGEEE 9
            R+A+G EE
Sbjct: 1146 RIALGNEE 1153
>NP_003598
          Length = 1719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RLAIGEEE 9
            R+A+G EE
Sbjct: 1227 RIALGNEE 1234
>XP_005273381
          Length = 1732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RLAIGEEE 9
            R+A+G EE
Sbjct: 1240 RIALGNEE 1247
>XP_005273380
          Length = 1751

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RLAIGEEE 9
            R+A+G EE
Sbjct: 1197 RIALGNEE 1204
>XP_005273379
          Length = 1754

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RLAIGEEE 9
            R+A+G EE
Sbjct: 1262 RIALGNEE 1269
>XP_006711899
          Length = 1770

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RLAIGEEE 9
            R+A+G EE
Sbjct: 1278 RIALGNEE 1285
>XP_005273378
          Length = 1781

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RLAIGEEE 9
            R+A+G EE
Sbjct: 1227 RIALGNEE 1234
>XP_005273377
          Length = 1794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RLAIGEEE 9
            R+A+G EE
Sbjct: 1240 RIALGNEE 1247
>XP_006711898
          Length = 1797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RLAIGEEE 9
            R+A+G EE
Sbjct: 1243 RIALGNEE 1250
>XP_006711897
          Length = 1816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RLAIGEEE 9
            R+A+G EE
Sbjct: 1262 RIALGNEE 1269
>XP_005273375
          Length = 1829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RLAIGEEE 9
            R+A+G EE
Sbjct: 1275 RIALGNEE 1282
>XP_005273374
          Length = 1832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RLAIGEEE 9
            R+A+G EE
Sbjct: 1278 RIALGNEE 1285
>NP_001243084
          Length = 2290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    SRLAIGEE 8
            SRL  GEE
Sbjct: 1863 SRLGAGEE 1870
>NP_065752
          Length = 285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRLAIGEEE 9
           +RLA GE+E
Sbjct: 195 ARLARGEKE 203
>NP_001186398
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRLAIGEEE 9
           +RLA GE+E
Sbjct: 217 ARLARGEKE 225
>NP_001184151
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AIGEEE 9
           A+GEEE
Sbjct: 564 AVGEEE 569
>NP_001159371
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AIGEEE 9
           A+GEEE
Sbjct: 727 AVGEEE 732
>NP_001184149
          Length = 679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AIGEEE 9
           A+GEEE
Sbjct: 658 AVGEEE 663
>NP_001184152
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AIGEEE 9
           A+GEEE
Sbjct: 497 AVGEEE 502
>NP_001184150
          Length = 507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AIGEEE 9
           A+GEEE
Sbjct: 486 AVGEEE 491
>NP_038476
          Length = 1556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LAIGEEE 9
           ++IGEEE
Sbjct: 701 ISIGEEE 707
>NP_001098101
          Length = 809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AIGEEE 9
           A+GEEE
Sbjct: 788 AVGEEE 793
>NP_006194
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AIGEEE 9
           A+GEEE
Sbjct: 652 AVGEEE 657
>NP_001248396
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AIGEEE 9
           A+GEEE
Sbjct: 137 AVGEEE 142
>NP_872589
          Length = 1524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LAIGEEE 9
           ++IGEEE
Sbjct: 669 ISIGEEE 675
>NP_113627
          Length = 388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRLAIGEEE 9
           SR A+GE+E
Sbjct: 152 SRGALGEKE 160
>NP_001184147
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AIGEEE 9
           A+GEEE
Sbjct: 724 AVGEEE 729
>NP_001191819
          Length = 331

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRLAIGEEE 9
           +RLA GE+E
Sbjct: 195 ARLARGEKE 203
>NP_001184148
          Length = 687

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AIGEEE 9
           A+GEEE
Sbjct: 666 AVGEEE 671
>NP_115517
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AIGEEE 9
           A+GEEE
Sbjct: 191 AVGEEE 196
>XP_005248598
          Length = 507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AIGEEE 9
           A+GEEE
Sbjct: 486 AVGEEE 491
>XP_005248597
          Length = 597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AIGEEE 9
           A+GEEE
Sbjct: 576 AVGEEE 581
>XP_005248595
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AIGEEE 9
           A+GEEE
Sbjct: 652 AVGEEE 657
>XP_005248594
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AIGEEE 9
           A+GEEE
Sbjct: 678 AVGEEE 683
>NP_078785
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AIGEEE 9
           A+GEEE
Sbjct: 285 AVGEEE 290
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.299    0.126    0.299 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 646,649
Number of extensions: 1060
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package