Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001261                                                              18    1935
XP_005271924                                                           18    1935
XP_005271923                                                           18    1935
XP_006715629                                                           17    2528
NP_078970                                                              17    2528
NP_001278086                                                           17    4312
NP_001181876                                                           17    4312
NP_937887                                                              17    4312
NP_937884                                                              17    4312
NP_004944                                                              17    4312
NP_001181875                                                           17    4312
NP_937885                                                              17    4312
NP_886553                                                              17    4312
NP_689836                                                              16    5631
NP_001139206                                                           16    5631
NP_001163873                                                           16    5631
NP_001231892                                                           16    5631
NP_001104488                                                           16    5631
NP_660093                                                              16    5631
NP_892009                                                              16    5631
NP_005186                                                              16    5631
XP_006718429                                                           16    5631
XP_006718428                                                           16    5631
XP_006718427                                                           16    5631
NP_001796                                                              16    7355
NP_001274353                                                           16    7355
NP_001272758                                                           16    7355
NP_001274364                                                           16    7355
NP_004355                                                              16    7355
NP_057427                                                              16    7355
NP_060395                                                              16    7355
NP_001123361                                                           16    7355
NP_001913                                                              16    7355
XP_006722770                                                           16    7355
XP_006722769                                                           16    7355
XP_006722768                                                           16    7355
XP_005272521                                                           16    7355
XP_006716870                                                           16    7355
XP_006716869                                                           16    7355
XP_006716868                                                           16    7355
XP_006716867                                                           16    7355
NP_003633                                                              15    9605
NP_060396                                                              15    9605
NP_001035810                                                           15    9605
NP_000393                                                              15    9605
NP_689658                                                              15    9605
NP_689632                                                              15    9605
NP_060442                                                              15    9605
XP_005274715                                                           15    9605
XP_005274714                                                           15    9605
XP_006720255                                                           15    9605
XP_006720254                                                           15    9605
XP_005273469                                                           15    9605
XP_005273468                                                           15    9605
XP_005273467                                                           15    9605
XP_005273466                                                           15    9605
XP_006712871                                                           15    9605
NP_005137                                                              15    9605
>NP_001261
          Length = 1710

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    SRDLAKKRS 9
            SRDLAKK +
Sbjct: 1314 SRDLAKKEA 1322
>XP_005271924
          Length = 1710

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    SRDLAKKRS 9
            SRDLAKK +
Sbjct: 1314 SRDLAKKEA 1322
>XP_005271923
          Length = 1798

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    SRDLAKKRS 9
            SRDLAKK +
Sbjct: 1314 SRDLAKKEA 1322
>XP_006715629
          Length = 1667

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKRS 9
           +RD+ KKRS
Sbjct: 367 ARDIGKKRS 375
>NP_078970
          Length = 1667

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKRS 9
           +RD+ KKRS
Sbjct: 367 ARDIGKKRS 375
>NP_001278086
          Length = 1559

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SRDLAKKRS 9
           +RD+A++RS
Sbjct: 847 ARDIARRRS 855
>NP_001181876
          Length = 1606

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SRDLAKKRS 9
           +RD+A++RS
Sbjct: 894 ARDIARRRS 902
>NP_937887
          Length = 1512

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SRDLAKKRS 9
           +RD+A++RS
Sbjct: 800 ARDIARRRS 808
>NP_937884
          Length = 1599

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SRDLAKKRS 9
           +RD+A++RS
Sbjct: 887 ARDIARRRS 895
>NP_004944
          Length = 1404

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SRDLAKKRS 9
           +RD+A++RS
Sbjct: 692 ARDIARRRS 700
>NP_001181875
          Length = 1606

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SRDLAKKRS 9
           +RD+A++RS
Sbjct: 894 ARDIARRRS 902
>NP_937885
          Length = 1435

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SRDLAKKRS 9
           +RD+A++RS
Sbjct: 723 ARDIARRRS 731
>NP_886553
          Length = 1600

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SRDLAKKRS 9
           +RD+A++RS
Sbjct: 888 ARDIARRRS 896
>NP_689836
          Length = 515

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SRDLAKKRS 9
          S+DL +KRS
Sbjct: 29 SKDLKQKRS 37
>NP_001139206
          Length = 477

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SRDLAKKRS 9
          S+DL +KRS
Sbjct: 29 SKDLKQKRS 37
>NP_001163873
          Length = 519

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SRDLAKKRS 9
          S+DL +KRS
Sbjct: 29 SKDLKQKRS 37
>NP_001231892
          Length = 2488

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKRS 9
           S+DLAK+ S
Sbjct: 524 SKDLAKRAS 532
>NP_001104488
          Length = 2365

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKRS 9
           S+DLAK+ S
Sbjct: 437 SKDLAKRAS 445
>NP_660093
          Length = 2429

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKRS 9
           S+DLAK+ S
Sbjct: 501 SKDLAKRAS 509
>NP_892009
          Length = 2432

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKRS 9
           S+DLAK+ S
Sbjct: 501 SKDLAKRAS 509
>NP_005186
          Length = 269

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKRS 9
           SRD AK+R+
Sbjct: 208 SRDKAKRRN 216
>XP_006718429
          Length = 2416

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKRS 9
           S+DLAK+ S
Sbjct: 452 SKDLAKRAS 460
>XP_006718428
          Length = 2455

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKRS 9
           S+DLAK+ S
Sbjct: 524 SKDLAKRAS 532
>XP_006718427
          Length = 2465

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKRS 9
           S+DLAK+ S
Sbjct: 501 SKDLAKRAS 509
>NP_001796
          Length = 281

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRDLAKKR 8
           SRD AK+R
Sbjct: 221 SRDKAKRR 228
>NP_001274353
          Length = 393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKRS 9
           SRD AK+R+
Sbjct: 334 SRDKAKQRN 342
>NP_001272758
          Length = 239

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKRS 9
           SRD AK+R+
Sbjct: 180 SRDKAKQRN 188
>NP_001274364
          Length = 344

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKRS 9
           SRD AK+R+
Sbjct: 285 SRDKAKQRN 293
>NP_004355
          Length = 358

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKRS 9
           SRD AK+R+
Sbjct: 299 SRDKAKQRN 307
>NP_057427
          Length = 3114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRDLAKKR 8
           S+DL KKR
Sbjct: 570 SQDLLKKR 577
>NP_060395
          Length = 1909

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SRDLAKKRS 9
            S+DL  KRS
Sbjct: 1175 SKDLRNKRS 1183
>NP_001123361
          Length = 552

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLAKKR 8
           DLAKKR
Sbjct: 146 DLAKKR 151
>NP_001913
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLAKKR 8
           DLAKKR
Sbjct: 146 DLAKKR 151
>XP_006722770
          Length = 1345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  SRDLAKKRS 9
          S+DL+++RS
Sbjct: 55 SQDLSRRRS 63
>XP_006722769
          Length = 1361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  SRDLAKKRS 9
          S+DL+++RS
Sbjct: 71 SQDLSRRRS 79
>XP_006722768
          Length = 1361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  SRDLAKKRS 9
          S+DL+++RS
Sbjct: 71 SQDLSRRRS 79
>XP_005272521
          Length = 1426

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SRDLAKKRS 9
           S+DL+++RS
Sbjct: 136 SQDLSRRRS 144
>XP_006716870
          Length = 1456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SRDLAKKRS 9
           S+DL  KRS
Sbjct: 722 SKDLRNKRS 730
>XP_006716869
          Length = 1722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SRDLAKKRS 9
           S+DL  KRS
Sbjct: 988 SKDLRNKRS 996
>XP_006716868
          Length = 1894

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SRDLAKKRS 9
            S+DL  KRS
Sbjct: 1224 SKDLRNKRS 1232
>XP_006716867
          Length = 1958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SRDLAKKRS 9
            S+DL  KRS
Sbjct: 1224 SKDLRNKRS 1232
>NP_003633
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RDLAKKR 8
           RDLAK R
Sbjct: 368 RDLAKMR 374
>NP_060396
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRDLAKKR 8
           SRD+ +KR
Sbjct: 409 SRDIKRKR 416
>NP_001035810
          Length = 515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SRDLAKKR 8
          S DLAKK+
Sbjct: 40 SGDLAKKK 47
>NP_000393
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SRDLAKKR 8
          S DLAKK+
Sbjct: 70 SGDLAKKK 77
>NP_689658
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SRDLAKKRS 9
           ++DLAKK +
Sbjct: 617 AKDLAKKEA 625
>NP_689632
          Length = 635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  RDLAKKR 8
          RDL KKR
Sbjct: 39 RDLDKKR 45
>NP_060442
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRDLAKKR 8
           SRD+ +KR
Sbjct: 404 SRDIKRKR 411
>XP_005274715
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SRDLAKKR 8
          S DLAKK+
Sbjct: 40 SGDLAKKK 47
>XP_005274714
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SRDLAKKR 8
          S DLAKK+
Sbjct: 70 SGDLAKKK 77
>XP_006720255
          Length = 438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRDLAKKR 8
           SRD+ +KR
Sbjct: 409 SRDIKRKR 416
>XP_006720254
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SRDLAKKR 8
           SRD+ +KR
Sbjct: 404 SRDIKRKR 411
>XP_005273469
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  RDLAKKR 8
          RDL KKR
Sbjct: 39 RDLDKKR 45
>XP_005273468
          Length = 608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  RDLAKKR 8
          RDL KKR
Sbjct: 39 RDLDKKR 45
>XP_005273467
          Length = 664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  RDLAKKR 8
          RDL KKR
Sbjct: 39 RDLDKKR 45
>XP_005273466
          Length = 672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  RDLAKKR 8
          RDL KKR
Sbjct: 39 RDLDKKR 45
>XP_006712871
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RDLAKKR 8
           RDLAK R
Sbjct: 362 RDLAKMR 368
>NP_005137
          Length = 800

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RDLAKKRS 9
           +DLA+KR+
Sbjct: 214 KDLAEKRA 221
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.117    0.277 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 505,477
Number of extensions: 1212
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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