Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001261                                                              18    1935
XP_005271924                                                           18    1935
XP_005271923                                                           18    1935
NP_001035810                                                           17    2528
NP_000393                                                              17    2528
XP_005274715                                                           17    2528
XP_005274714                                                           17    2528
NP_000882                                                              17    4312
NP_000048                                                              16    5631
NP_001274176                                                           16    5631
NP_001274175                                                           16    5631
NP_113663                                                              16    5631
XP_005263558                                                           16    5631
XP_005275805                                                           16    5631
NP_001009899                                                           16    7355
NP_005498                                                              16    7355
NP_002461                                                              16    7355
NP_001136087                                                           16    7355
NP_009120                                                              16    7355
NP_002378                                                              16    7355
NP_001078846                                                           16    7355
NP_001136086                                                           16    7355
NP_001803                                                              16    7355
NP_005683                                                              16    7355
XP_006721591                                                           16    7355
XP_006715887                                                           16    7355
XP_005249988                                                           16    7355
XP_005272048                                                           16    7355
XP_006714680                                                           16    7355
XP_006714128                                                           16    7355
XP_006714127                                                           16    7355
XP_005247266                                                           16    7355
XP_005247265                                                           16    7355
XP_006712034                                                           16    7355
XP_005264284                                                           16    7355
XP_005264283                                                           16    7355
XP_005264282                                                           16    7355
NP_001136088                                                           16    7355
NP_056067                                                              16    7355
NP_001121649                                                           15    9605
NP_001796                                                              15    9605
NP_001121648                                                           15    9605
NP_000452                                                              15    9605
NP_001239563                                                           15    9605
NP_689845                                                              15    9605
NP_689658                                                              15    9605
NP_659482                                                              15    9605
NP_031391                                                              15    9605
NP_002087                                                              15    9605
XP_005248180                                                           15    9605
XP_006714090                                                           15    9605
XP_005265482                                                           15    9605
XP_005265481                                                           15    9605
XP_005265480                                                           15    9605
XP_006713381                                                           15    9605
XP_005265478                                                           15    9605
XP_006713380                                                           15    9605
XP_005265477                                                           15    9605
NP_003206                                                              15    9605
>NP_001261
          Length = 1710

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    SRDLAKKK 8
            SRDLAKK+
Sbjct: 1314 SRDLAKKE 1321
>XP_005271924
          Length = 1710

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    SRDLAKKK 8
            SRDLAKK+
Sbjct: 1314 SRDLAKKE 1321
>XP_005271923
          Length = 1798

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    SRDLAKKK 8
            SRDLAKK+
Sbjct: 1314 SRDLAKKE 1321
>NP_001035810
          Length = 515

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  SRDLAKKKL 9
          S DLAKKK+
Sbjct: 40 SGDLAKKKI 48
>NP_000393
          Length = 545

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  SRDLAKKKL 9
          S DLAKKK+
Sbjct: 70 SGDLAKKKI 78
>XP_005274715
          Length = 516

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  SRDLAKKKL 9
          S DLAKKK+
Sbjct: 40 SGDLAKKKI 48
>XP_005274714
          Length = 546

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  SRDLAKKKL 9
          S DLAKKK+
Sbjct: 70 SGDLAKKKI 78
>NP_000882
          Length = 427

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SRDLAKKK 8
           +RDLA+KK
Sbjct: 358 ARDLAEKK 365
>NP_000048
          Length = 1417

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SRDLAKKKL 9
           SRD A KKL
Sbjct: 131 SRDTALKKL 139
>NP_001274176
          Length = 1286

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SRDLAKKKL 9
           SRD A KKL
Sbjct: 131 SRDTALKKL 139
>NP_001274175
          Length = 1417

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SRDLAKKKL 9
           SRD A KKL
Sbjct: 131 SRDTALKKL 139
>NP_113663
          Length = 854

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDLAKKKL 9
           RDL +KKL
Sbjct: 791 RDLLRKKL 798
>XP_005263558
          Length = 833

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDLAKKKL 9
           RDL +KKL
Sbjct: 770 RDLLRKKL 777
>XP_005275805
          Length = 309

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SRDLAKKKL 9
           SRD AKK L
Sbjct: 219 SRDNAKKSL 227
>NP_001009899
          Length = 2245

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    DLAKKK 8
            DLAKKK
Sbjct: 1010 DLAKKK 1015
>NP_005498
          Length = 166

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SRDLAKKKL 9
           S+D  KKKL
Sbjct: 120 SKDAIKKKL 128
>NP_002461
          Length = 1940

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLAKKK 8
           DLAKKK
Sbjct: 204 DLAKKK 209
>NP_001136087
          Length = 1160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLAKKK 8
           DLAKKK
Sbjct: 738 DLAKKK 743
>NP_009120
          Length = 623

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3 DLAKKK 8
         DLAKKK
Sbjct: 4 DLAKKK 9
>NP_002378
          Length = 829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RDLAKKKL 9
          RDL +KKL
Sbjct: 46 RDLLEKKL 53
>NP_001078846
          Length = 1019

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDLAKKKL 9
           RDL +KKL
Sbjct: 236 RDLLEKKL 243
>NP_001136086
          Length = 1196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLAKKK 8
           DLAKKK
Sbjct: 738 DLAKKK 743
>NP_001803
          Length = 943

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLAKKK 8
           DLAKKK
Sbjct: 624 DLAKKK 629
>NP_005683
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3 DLAKKK 8
         DLAKKK
Sbjct: 4 DLAKKK 9
>XP_006721591
          Length = 1940

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLAKKK 8
           DLAKKK
Sbjct: 204 DLAKKK 209
>XP_006715887
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3 DLAKKK 8
         DLAKKK
Sbjct: 4 DLAKKK 9
>XP_005249988
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3 DLAKKK 8
         DLAKKK
Sbjct: 4 DLAKKK 9
>XP_005272048
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RDLAKKKL 9
          RDL +KKL
Sbjct: 46 RDLLEKKL 53
>XP_006714680
          Length = 1002

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDLAKKKL 9
           RDL +KKL
Sbjct: 197 RDLLEKKL 204
>XP_006714128
          Length = 730

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLAKKK 8
           DLAKKK
Sbjct: 411 DLAKKK 416
>XP_006714127
          Length = 935

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLAKKK 8
           DLAKKK
Sbjct: 624 DLAKKK 629
>XP_005247266
          Length = 2189

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLAKKK 8
           DLAKKK
Sbjct: 954 DLAKKK 959
>XP_005247265
          Length = 2211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLAKKK 8
           DLAKKK
Sbjct: 976 DLAKKK 981
>XP_006712034
          Length = 1195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLAKKK 8
           DLAKKK
Sbjct: 773 DLAKKK 778
>XP_005264284
          Length = 1196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLAKKK 8
           DLAKKK
Sbjct: 738 DLAKKK 743
>XP_005264283
          Length = 1231

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLAKKK 8
           DLAKKK
Sbjct: 773 DLAKKK 778
>XP_005264282
          Length = 1231

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLAKKK 8
           DLAKKK
Sbjct: 773 DLAKKK 778
>NP_001136088
          Length = 1160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLAKKK 8
           DLAKKK
Sbjct: 738 DLAKKK 743
>NP_056067
          Length = 1231

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLAKKK 8
           DLAKKK
Sbjct: 773 DLAKKK 778
>NP_001121649
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKKL 9
           S+ LAK+KL
Sbjct: 183 SKRLAKRKL 191
>NP_001796
          Length = 281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SRDLAKKKL 9
           SRD AK+++
Sbjct: 221 SRDKAKRRI 229
>NP_001121648
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKKL 9
           S+ LAK+KL
Sbjct: 183 SKRLAKRKL 191
>NP_000452
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKKL 9
           S+ LAK+KL
Sbjct: 183 SKRLAKRKL 191
>NP_001239563
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKKL 9
           S+ LAK+KL
Sbjct: 183 SKRLAKRKL 191
>NP_689845
          Length = 976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RDLAKKK 8
           +DLAK+K
Sbjct: 549 KDLAKRK 555
>NP_689658
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SRDLAKKK 8
           ++DLAKK+
Sbjct: 617 AKDLAKKE 624
>NP_659482
          Length = 595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SRDLAKKKL 9
           +RD+AK +L
Sbjct: 275 ARDIAKNQL 283
>NP_031391
          Length = 665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SRDLAKKKL 9
           +RD+ KK+L
Sbjct: 551 NRDILKKEL 559
>NP_002087
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RDLAKKKL 9
          RDL+ KK+
Sbjct: 49 RDLSNKKI 56
>XP_005248180
          Length = 551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  SRDLAKKKL 9
          SRDL  KKL
Sbjct: 18 SRDLWVKKL 26
>XP_006714090
          Length = 551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  SRDLAKKKL 9
          SRDL  KKL
Sbjct: 18 SRDLWVKKL 26
>XP_005265482
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKKL 9
           S+ LAK+KL
Sbjct: 183 SKRLAKRKL 191
>XP_005265481
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKKL 9
           S+ LAK+KL
Sbjct: 183 SKRLAKRKL 191
>XP_005265480
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKKL 9
           S+ LAK+KL
Sbjct: 183 SKRLAKRKL 191
>XP_006713381
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKKL 9
           S+ LAK+KL
Sbjct: 183 SKRLAKRKL 191
>XP_005265478
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKKL 9
           S+ LAK+KL
Sbjct: 183 SKRLAKRKL 191
>XP_006713380
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKKL 9
           S+ LAK+KL
Sbjct: 183 SKRLAKRKL 191
>XP_005265477
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SRDLAKKKL 9
           S+ LAK+KL
Sbjct: 198 SKRLAKRKL 206
>NP_003206
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SRDLAKKKL 9
           SRDL  KKL
Sbjct: 98  SRDLWVKKL 106
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.125    0.300 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 564,539
Number of extensions: 1392
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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