Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004251                                                              20     509
NP_056110                                                              17    2528
XP_005258159                                                           17    2528
XP_006722384                                                           17    2528
NP_001166935                                                           17    3301
NP_060111                                                              17    3301
NP_001166934                                                           17    3301
NP_001166936                                                           17    3301
NP_060066                                                              17    3301
NP_001239029                                                           17    3301
NP_001239032                                                           17    3301
NP_001239031                                                           17    3301
XP_006719559                                                           17    3301
XP_006719558                                                           17    3301
XP_005269072                                                           17    3301
XP_005269071                                                           17    3301
XP_005269070                                                           17    3301
XP_006719557                                                           17    3301
XP_005269069                                                           17    3301
XP_006719556                                                           17    3301
XP_005269068                                                           17    3301
XP_005269067                                                           17    3301
XP_005269066                                                           17    3301
XP_005269065                                                           17    3301
XP_005269064                                                           17    3301
NP_775739                                                              17    4312
NP_001231695                                                           17    4312
NP_071347                                                              17    4312
NP_060691                                                              17    4312
XP_006723605                                                           17    4312
XP_006714478                                                           17    4312
XP_005265766                                                           17    4312
XP_006713348                                                           17    4312
NP_001229808                                                           16    5631
NP_001229806                                                           16    5631
NP_001229804                                                           16    5631
NP_060725                                                              16    5631
NP_787052                                                              16    5631
NP_848555                                                              16    7355
NP_036461                                                              16    7355
NP_006715                                                              16    7355
NP_005913                                                              16    7355
NP_001361                                                              16    7355
XP_005260719                                                           16    7355
XP_006723604                                                           16    7355
XP_006721858                                                           16    7355
XP_005267046                                                           16    7355
XP_005267045                                                           16    7355
XP_006712019                                                           16    7355
NP_008986                                                              15    9605
NP_113626                                                              15    9605
NP_057647                                                              15    9605
NP_001123292                                                           15    9605
NP_005040                                                              15    9605
NP_001245213                                                           15    9605
XP_006723973                                                           15    9605
XP_005258025                                                           15    9605
XP_005254490                                                           15    9605
XP_006717660                                                           15    9605
XP_005272154                                                           15    9605
XP_005272153                                                           15    9605
XP_005272152                                                           15    9605
XP_006710159                                                           15    9605
NP_001004686                                                           15    9605
NP_787107                                                              15    9605
NP_001001963                                                           15    9605
NP_001004687                                                           15    9605
>NP_004251
          Length = 1208

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SRAVAHIFH 9
            SRAVA IFH
Sbjct: 1157 SRAVARIFH 1165
>NP_056110
          Length = 2005

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SRAVAHIFH 9
           +R +AHI+H
Sbjct: 343 TRQLAHIYH 351
>XP_005258159
          Length = 1817

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SRAVAHIFH 9
           +R +AHI+H
Sbjct: 155 TRQLAHIYH 163
>XP_006722384
          Length = 1877

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SRAVAHIFH 9
           +R +AHI+H
Sbjct: 215 TRQLAHIYH 223
>NP_001166935
          Length = 1674

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRAVAHIF 8
           SRAV H+F
Sbjct: 115 SRAVKHLF 122
>NP_060111
          Length = 1661

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRAVAHIF 8
           SRAV H+F
Sbjct: 115 SRAVKHLF 122
>NP_001166934
          Length = 1637

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRAVAHIF 8
           SRAV H+F
Sbjct: 115 SRAVKHLF 122
>NP_001166936
          Length = 1621

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRAVAHIF 8
           SRAV H+F
Sbjct: 115 SRAVKHLF 122
>NP_060066
          Length = 1624

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RAVAHIF 8
           RA+AH+F
Sbjct: 115 RAIAHLF 121
>NP_001239029
          Length = 1637

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RAVAHIF 8
           RA+AH+F
Sbjct: 115 RAIAHLF 121
>NP_001239032
          Length = 1610

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RAVAHIF 8
           RA+AH+F
Sbjct: 115 RAIAHLF 121
>NP_001239031
          Length = 1623

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RAVAHIF 8
           RA+AH+F
Sbjct: 115 RAIAHLF 121
>XP_006719559
          Length = 1650

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRAVAHIF 8
           SRAV H+F
Sbjct: 115 SRAVKHLF 122
>XP_006719558
          Length = 1644

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRAVAHIF 8
           SRAV H+F
Sbjct: 115 SRAVKHLF 122
>XP_005269072
          Length = 1607

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRAVAHIF 8
           SRAV H+F
Sbjct: 115 SRAVKHLF 122
>XP_005269071
          Length = 1614

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRAVAHIF 8
           SRAV H+F
Sbjct: 115 SRAVKHLF 122
>XP_005269070
          Length = 1627

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRAVAHIF 8
           SRAV H+F
Sbjct: 115 SRAVKHLF 122
>XP_006719557
          Length = 1631

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRAVAHIF 8
           SRAV H+F
Sbjct: 115 SRAVKHLF 122
>XP_005269069
          Length = 1632

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRAVAHIF 8
           SRAV H+F
Sbjct: 115 SRAVKHLF 122
>XP_006719556
          Length = 1655

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRAVAHIF 8
           SRAV H+F
Sbjct: 115 SRAVKHLF 122
>XP_005269068
          Length = 1657

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRAVAHIF 8
           SRAV H+F
Sbjct: 115 SRAVKHLF 122
>XP_005269067
          Length = 1662

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRAVAHIF 8
           SRAV H+F
Sbjct: 115 SRAVKHLF 122
>XP_005269066
          Length = 1668

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRAVAHIF 8
           SRAV H+F
Sbjct: 115 SRAVKHLF 122
>XP_005269065
          Length = 1670

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRAVAHIF 8
           SRAV H+F
Sbjct: 115 SRAVKHLF 122
>XP_005269064
          Length = 1675

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SRAVAHIF 8
           SRAV H+F
Sbjct: 115 SRAVKHLF 122
>NP_775739
          Length = 216

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RAVAHIFH 9
           R  AHI+H
Sbjct: 157 RVYAHIYH 164
>NP_001231695
          Length = 221

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RAVAHIFH 9
           R  AHI+H
Sbjct: 162 RVYAHIYH 169
>NP_071347
          Length = 1314

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VAHIFH 9
           +AHIFH
Sbjct: 317 LAHIFH 322
>NP_060691
          Length = 216

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RAVAHIFH 9
           R  AHI+H
Sbjct: 157 RVYAHIYH 164
>XP_006723605
          Length = 176

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2 RAVAHIFH 9
         + V H+FH
Sbjct: 2 KGVTHVFH 9
>XP_006714478
          Length = 174

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RAVAHIFH 9
           R  AHI+H
Sbjct: 115 RVYAHIYH 122
>XP_005265766
          Length = 221

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RAVAHIFH 9
           R  AHI+H
Sbjct: 162 RVYAHIYH 169
>XP_006713348
          Length = 1314

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VAHIFH 9
           +AHIFH
Sbjct: 317 LAHIFH 322
>NP_001229808
          Length = 756

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SRAVAHIFH 9
           S  +AH FH
Sbjct: 284 SMIIAHAFH 292
>NP_001229806
          Length = 800

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SRAVAHIFH 9
           S  +AH FH
Sbjct: 328 SMIIAHAFH 336
>NP_001229804
          Length = 891

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SRAVAHIFH 9
           S  +AH FH
Sbjct: 419 SMIIAHAFH 427
>NP_060725
          Length = 826

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SRAVAHIFH 9
           S  +AH FH
Sbjct: 354 SMIIAHAFH 362
>NP_787052
          Length = 882

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   VAHIFH 9
           V HIFH
Sbjct: 829 VVHIFH 834
>NP_848555
          Length = 197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 4  VAHIFH 9
          V H+FH
Sbjct: 26 VTHVFH 31
>NP_036461
          Length = 238

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2  RAVAHIFH 9
          R V H FH
Sbjct: 90 RTVEHCFH 97
>NP_006715
          Length = 1558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SRAVAHIFH 9
           SRA+  +FH
Sbjct: 798 SRALKELFH 806
>NP_005913
          Length = 1608

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SRAVAHIFH 9
           SRA+  +FH
Sbjct: 798 SRALKELFH 806
>NP_001361
          Length = 4158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RAVAHIFH 9
           RAV HI++
Sbjct: 239 RAVTHIYN 246
>XP_005260719
          Length = 145

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 4  VAHIFH 9
          V H+FH
Sbjct: 26 VTHVFH 31
>XP_006723604
          Length = 198

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 4  VAHIFH 9
          V H+FH
Sbjct: 26 VTHVFH 31
>XP_006721858
          Length = 269

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2  RAVAHIFH 9
          R V H FH
Sbjct: 90 RTVEHCFH 97
>XP_005267046
          Length = 1554

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SRAVAHIFH 9
           SRA+  +FH
Sbjct: 798 SRALKELFH 806
>XP_005267045
          Length = 1604

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SRAVAHIFH 9
           SRA+  +FH
Sbjct: 798 SRALKELFH 806
>XP_006712019
          Length = 4158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RAVAHIFH 9
           RAV HI++
Sbjct: 239 RAVTHIYN 246
>NP_008986
          Length = 1390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    SRAVAHI 7
            SRAV HI
Sbjct: 1208 SRAVIHI 1214
>NP_113626
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SRAVAH 6
           SRA+AH
Sbjct: 444 SRAIAH 449
>NP_057647
          Length = 266

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 4   VAHIFH 9
           V H+FH
Sbjct: 172 VQHVFH 177
>NP_001123292
          Length = 912

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SRAVAHIF 8
           SRA+ H++
Sbjct: 896 SRAIKHLY 903
>NP_005040
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  RAVAHIFH 9
          R+V H FH
Sbjct: 87 RSVLHHFH 94
>NP_001245213
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SRAVAHIF 8
           SRA+ H F
Sbjct: 170 SRAINHFF 177
>XP_006723973
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  RAVAHIFH 9
          R+V H FH
Sbjct: 87 RSVLHHFH 94
>XP_005258025
          Length = 912

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SRAVAHIF 8
           SRA+ H++
Sbjct: 896 SRAIKHLY 903
>XP_005254490
          Length = 247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 4   VAHIFH 9
           V H+FH
Sbjct: 153 VQHVFH 158
>XP_006717660
          Length = 1369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    SRAVAHI 7
            SRAV HI
Sbjct: 1187 SRAVIHI 1193
>XP_005272154
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SRAVAH 6
           SRA+AH
Sbjct: 426 SRAIAH 431
>XP_005272153
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SRAVAH 6
           SRA+AH
Sbjct: 426 SRAIAH 431
>XP_005272152
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SRAVAH 6
           SRA+AH
Sbjct: 444 SRAIAH 449
>XP_006710159
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  RAVAHIFH 9
          R+V H FH
Sbjct: 87 RSVLHHFH 94
>NP_001004686
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SRAVAHIF 8
           SRA+ H F
Sbjct: 170 SRAINHFF 177
>NP_787107
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SRAVAHIF 8
           SRA+ H F
Sbjct: 170 SRAIDHFF 177
>NP_001001963
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SRAVAHIF 8
           SRA+ H F
Sbjct: 170 SRAINHFF 177
>NP_001004687
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SRAVAHIF 8
           SRA+ H F
Sbjct: 170 SRAINHFF 177
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.342    0.135    0.434 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 446,555
Number of extensions: 631
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

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