Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           20     390
NP_004561                                                              20     390
XP_005253450                                                           20     390
XP_006719151                                                           20     390
NP_780775                                                              17    2528
NP_001230199                                                           17    2528
NP_055176                                                              17    2528
NP_852125                                                              17    2528
XP_006722357                                                           17    2528
NP_653271                                                              16    5631
NP_001269353                                                           16    5631
NP_003046                                                              16    5631
XP_006723077                                                           16    7355
NP_001073905                                                           16    7355
NP_060853                                                              15    9605
NP_001276900                                                           15    9605
NP_001276901                                                           15    9605
NP_001120844                                                           15    9605
NP_003419                                                              15    9605
XP_006719810                                                           15    9605
XP_005266243                                                           15    9605
XP_005266242                                                           15    9605
XP_005263754                                                           15    9605

>NP_001275701
          Length = 1486

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  SQVSLGFEQ 9
          SQVSLGF+Q
Sbjct: 34 SQVSLGFDQ 42



>NP_004561
          Length = 1445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  SQVSLGFEQ 9
          SQVSLGF+Q
Sbjct: 34 SQVSLGFDQ 42



>XP_005253450
          Length = 1486

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  SQVSLGFEQ 9
          SQVSLGF+Q
Sbjct: 34 SQVSLGFDQ 42



>XP_006719151
          Length = 1486

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  SQVSLGFEQ 9
          SQVSLGF+Q
Sbjct: 34 SQVSLGFDQ 42



>NP_780775
          Length = 1026

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   SQVSLGFE 8
           SQVSLG+E
Sbjct: 914 SQVSLGWE 921



>NP_001230199
          Length = 1100

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   SQVSLGFE 8
           SQVSLG+E
Sbjct: 988 SQVSLGWE 995



>NP_055176
          Length = 1100

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   SQVSLGFE 8
           SQVSLG+E
Sbjct: 988 SQVSLGWE 995



>NP_852125
          Length = 407

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SQVSLGFE 8
           SQ+SLGF+
Sbjct: 398 SQISLGFK 405



>XP_006722357
          Length = 347

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   QVSLGFEQ 9
           QVSLGF Q
Sbjct: 181 QVSLGFPQ 188



>NP_653271
          Length = 1454

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SQVSLGF 7
           +QVSLGF
Sbjct: 560 NQVSLGF 566



>NP_001269353
          Length = 963

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  SQVSLGF 7
          +QVSLGF
Sbjct: 69 NQVSLGF 75



>NP_003046
          Length = 532

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SLGFEQ 9
           SLGFEQ
Sbjct: 445 SLGFEQ 450



>XP_006723077
          Length = 384

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQVSLGFEQ 9
           S +SLG++Q
Sbjct: 108 SGISLGYDQ 116



>NP_001073905
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQVSLGFEQ 9
           S +SLG++Q
Sbjct: 108 SGISLGYDQ 116



>NP_060853
          Length = 1336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SQVSLGFEQ 9
           SQ+  GF+Q
Sbjct: 595 SQIPQGFQQ 603



>NP_001276900
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SQVSLGFE 8
          S VSLG+E
Sbjct: 43 SLVSLGYE 50



>NP_001276901
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SQVSLGFE 8
          S VSLG+E
Sbjct: 43 SLVSLGYE 50



>NP_001120844
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SQVSLGFE 8
          S VSLG+E
Sbjct: 43 SLVSLGYE 50



>NP_003419
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SQVSLGFE 8
          S VSLG+E
Sbjct: 43 SLVSLGYE 50



>XP_006719810
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SQVSLGFE 8
          S VSLG+E
Sbjct: 43 SLVSLGYE 50



>XP_005266243
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SQVSLGFE 8
          S VSLG+E
Sbjct: 43 SLVSLGYE 50



>XP_005266242
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SQVSLGFE 8
          S VSLG+E
Sbjct: 43 SLVSLGYE 50



>XP_005263754
          Length = 1133

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SQVSLGFEQ 9
           SQ+  GF+Q
Sbjct: 595 SQIPQGFQQ 603



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.125    0.312 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 417,067
Number of extensions: 356
Number of successful extensions: 23
Number of sequences better than 10000.0: 23
Number of HSP's gapped: 23
Number of HSP's successfully gapped: 23
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)