Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              20     509
NP_005913                                                              20     509
XP_005267046                                                           20     509
XP_005267045                                                           20     509
NP_001074319                                                           17    2528
NP_004044                                                              17    4312
NP_207646                                                              16    5631
NP_002200                                                              16    5631
NP_055244                                                              16    5631
NP_001107852                                                           16    5631
XP_006721107                                                           16    5631
XP_005255370                                                           16    5631
XP_005268191                                                           16    5631
XP_005247419                                                           16    5631
NP_001032402                                                           16    5631
NP_056125                                                              16    7355
NP_001364                                                              16    7355
NP_008911                                                              16    7355
NP_079225                                                              16    7355
XP_005273518                                                           16    7355
XP_006716381                                                           16    7355
XP_005250652                                                           16    7355
XP_005250651                                                           16    7355
XP_006716189                                                           16    7355
XP_005250650                                                           16    7355
XP_006714376                                                           16    7355
XP_006714375                                                           16    7355
XP_006711798                                                           16    7355
NP_006256                                                              15    9605
NP_001137481                                                           15    9605
NP_001271230                                                           15    9605
NP_001137482                                                           15    9605
NP_001137480                                                           15    9605
NP_001271231                                                           15    9605
NP_061155                                                              15    9605
NP_001122312                                                           15    9605
NP_001122311                                                           15    9605
NP_000711                                                              15    9605
NP_001137475                                                           15    9605
NP_001137477                                                           15    9605
NP_001137478                                                           15    9605
NP_001137476                                                           15    9605
NP_115928                                                              15    9605
NP_004873                                                              15    9605
NP_064613                                                              15    9605
NP_001161213                                                           15    9605
XP_005262403                                                           15    9605
XP_005262402                                                           15    9605
XP_005262401                                                           15    9605
XP_005262400                                                           15    9605
XP_005262399                                                           15    9605
XP_006715810                                                           15    9605
XP_006715809                                                           15    9605
XP_005248552                                                           15    9605
XP_005265505                                                           15    9605
XP_006713388                                                           15    9605
NP_955469                                                              15    9605
NP_955471                                                              15    9605
NP_955470                                                              15    9605
>NP_006715
          Length = 1558

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SQSNLKEKM 9
           S+SNLKEKM
Sbjct: 109 SRSNLKEKM 117
>NP_005913
          Length = 1608

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SQSNLKEKM 9
           S+SNLKEKM
Sbjct: 109 SRSNLKEKM 117
>XP_005267046
          Length = 1554

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SQSNLKEKM 9
           S+SNLKEKM
Sbjct: 109 SRSNLKEKM 117
>XP_005267045
          Length = 1604

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SQSNLKEKM 9
           S+SNLKEKM
Sbjct: 109 SRSNLKEKM 117
>NP_001074319
          Length = 783

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SQSNLKEKM 9
           SQ+NL+EK+
Sbjct: 334 SQNNLQEKL 342
>NP_004044
          Length = 437

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SNLKEKM 9
           SNLKE+M
Sbjct: 239 SNLKERM 245
>NP_207646
          Length = 2572

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QSNLKEKM 9
           +SN KEKM
Sbjct: 829 ESNSKEKM 836
>NP_002200
          Length = 1170

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    NLKEKM 9
            NLKEKM
Sbjct: 1120 NLKEKM 1125
>NP_055244
          Length = 984

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   QSNLKEK 8
           Q NLKEK
Sbjct: 336 QKNLKEK 342
>NP_001107852
          Length = 1086

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    NLKEKM 9
            NLKEKM
Sbjct: 1036 NLKEKM 1041
>XP_006721107
          Length = 1087

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    NLKEKM 9
            NLKEKM
Sbjct: 1037 NLKEKM 1042
>XP_005255370
          Length = 1169

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    NLKEKM 9
            NLKEKM
Sbjct: 1119 NLKEKM 1124
>XP_005268191
          Length = 2572

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QSNLKEKM 9
           +SN KEKM
Sbjct: 829 ESNSKEKM 836
>XP_005247419
          Length = 1014

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   QSNLKEK 8
           Q NLKEK
Sbjct: 336 QKNLKEK 342
>NP_001032402
          Length = 211

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  QSNLKEK 8
          +SNLKEK
Sbjct: 47 KSNLKEK 53
>NP_056125
          Length = 1047

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SQSNLKEK 8
           SQS+LKE+
Sbjct: 119 SQSHLKEQ 126
>NP_001364
          Length = 4515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SQSNLKEKM 9
            ++ NLKEK+
Sbjct: 2846 NRENLKEKL 2854
>NP_008911
          Length = 399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQSNLKEKM 9
           S +N+KEK+
Sbjct: 292 SYANIKEKL 300
>NP_079225
          Length = 1192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQSNLKEKM 9
           S+SNL EK+
Sbjct: 298 SRSNLAEKV 306
>XP_005273518
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SQSNLKEK 8
           SQS+LKE+
Sbjct: 119 SQSHLKEQ 126
>XP_006716381
          Length = 1014

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  SQSNLKEK 8
          SQS+LKE+
Sbjct: 86 SQSHLKEQ 93
>XP_005250652
          Length = 379

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQSNLKEKM 9
           S +N+KEK+
Sbjct: 272 SYANIKEKL 280
>XP_005250651
          Length = 379

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQSNLKEKM 9
           S +N+KEK+
Sbjct: 272 SYANIKEKL 280
>XP_006716189
          Length = 399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQSNLKEKM 9
           S +N+KEK+
Sbjct: 292 SYANIKEKL 300
>XP_005250650
          Length = 399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQSNLKEKM 9
           S +N+KEK+
Sbjct: 292 SYANIKEKL 300
>XP_006714376
          Length = 815

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQSNLKEKM 9
           S+SNL EK+
Sbjct: 298 SRSNLAEKV 306
>XP_006714375
          Length = 1208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQSNLKEKM 9
           S+SNL EK+
Sbjct: 298 SRSNLAEKV 306
>XP_006711798
          Length = 4586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SQSNLKEKM 9
            ++ NLKEK+
Sbjct: 2908 NRENLKEKL 2916
>NP_006256
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQSNLKEKM 9
           S SNL EK+
Sbjct: 198 STSNLNEKI 206
>NP_001137481
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SQSNLKEK 8
           S SNL+EK
Sbjct: 719 SYSNLEEK 726
>NP_001271230
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QSNLKEKM 9
           Q N+K+KM
Sbjct: 676 QVNIKQKM 683
>NP_001137482
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SQSNLKEK 8
           S SNL+EK
Sbjct: 719 SYSNLEEK 726
>NP_001137480
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SQSNLKEK 8
           S SNL+EK
Sbjct: 719 SYSNLEEK 726
>NP_001271231
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QSNLKEKM 9
           Q N+K+KM
Sbjct: 675 QVNIKQKM 682
>NP_061155
          Length = 1124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QSNLKEKM 9
           Q N+K+KM
Sbjct: 713 QVNIKQKM 720
>NP_001122312
          Length = 2161

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQSNLKEKM 9
           S+ N+KEK+
Sbjct: 849 SELNMKEKI 857
>NP_001122311
          Length = 2137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQSNLKEKM 9
           S+ N+KEK+
Sbjct: 849 SELNMKEKI 857
>NP_000711
          Length = 2181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQSNLKEKM 9
           S+ N+KEK+
Sbjct: 869 SELNMKEKI 877
>NP_001137475
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SQSNLKEK 8
           S SNL+EK
Sbjct: 719 SYSNLEEK 726
>NP_001137477
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SQSNLKEK 8
           S SNL+EK
Sbjct: 719 SYSNLEEK 726
>NP_001137478
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SQSNLKEK 8
           S SNL+EK
Sbjct: 719 SYSNLEEK 726
>NP_001137476
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SQSNLKEK 8
           S SNL+EK
Sbjct: 719 SYSNLEEK 726
>NP_115928
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SQSNLKEK 8
           S SNL+EK
Sbjct: 719 SYSNLEEK 726
>NP_004873
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SQSNLKEK 8
           S+SN KEK
Sbjct: 280 SESNNKEK 287
>NP_064613
          Length = 1160

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SQSNLKEK 8
            SQS L+EK
Sbjct: 1101 SQSELEEK 1108
>NP_001161213
          Length = 251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QSNLKEKM 9
           +SNL EKM
Sbjct: 209 ESNLIEKM 216
>XP_005262403
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SQSNLKEK 8
           S SNL+EK
Sbjct: 719 SYSNLEEK 726
>XP_005262402
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SQSNLKEK 8
           S SNL+EK
Sbjct: 719 SYSNLEEK 726
>XP_005262401
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SQSNLKEK 8
           S SNL+EK
Sbjct: 719 SYSNLEEK 726
>XP_005262400
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SQSNLKEK 8
           S SNL+EK
Sbjct: 719 SYSNLEEK 726
>XP_005262399
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SQSNLKEK 8
           S SNL+EK
Sbjct: 719 SYSNLEEK 726
>XP_006715810
          Length = 1105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QSNLKEKM 9
           Q N+K+KM
Sbjct: 676 QVNIKQKM 683
>XP_006715809
          Length = 1142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QSNLKEKM 9
           Q N+K+KM
Sbjct: 713 QVNIKQKM 720
>XP_005248552
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QSNLKEKM 9
           +SNL EKM
Sbjct: 270 ESNLIEKM 277
>XP_005265505
          Length = 2146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQSNLKEKM 9
           S+ N+KEK+
Sbjct: 849 SELNMKEKI 857
>XP_006713388
          Length = 2194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQSNLKEKM 9
           S+ N+KEK+
Sbjct: 869 SELNMKEKI 877
>NP_955469
          Length = 1156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SQSNLKEK 8
            SQS L+EK
Sbjct: 1097 SQSELEEK 1104
>NP_955471
          Length = 1023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SQSNLKEK 8
           SQS L+EK
Sbjct: 964 SQSELEEK 971
>NP_955470
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SQSNLKEK 8
            SQS L+EK
Sbjct: 1002 SQSELEEK 1009
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.286    0.101    0.222 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 576,451
Number of extensions: 816
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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