Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001072990                                                           17    2528
NP_001257943                                                           17    2528
NP_004977                                                              17    2528
XP_006720204                                                           17    2528
XP_006720203                                                           17    2528
XP_006720202                                                           17    2528
XP_006720201                                                           17    2528
NP_001072989                                                           17    2528
NP_001186028                                                           17    4312
NP_001186026                                                           17    4312
NP_001186027                                                           17    4312
NP_001186025                                                           17    4312
NP_003924                                                              17    4312
NP_001273393                                                           17    4312
NP_004314                                                              16    5631
NP_001165886                                                           16    5631
NP_001157819                                                           16    5631
NP_001157814                                                           16    5631
NP_001157816                                                           16    5631
NP_056457                                                              16    5631
NP_001157817                                                           16    5631
NP_001157815                                                           16    5631
NP_001157818                                                           16    5631
NP_001191227                                                           16    5631
NP_689650                                                              16    5631
XP_005247400                                                           16    5631
XP_005247399                                                           16    5631
XP_006713644                                                           16    5631
XP_006713643                                                           16    5631
XP_006713642                                                           16    5631
XP_005247398                                                           16    5631
XP_005247397                                                           16    5631
XP_005247396                                                           16    5631
XP_006713641                                                           16    5631
XP_006713640                                                           16    5631
NP_003972                                                              16    7355
NP_955445                                                              16    7355
NP_001254509                                                           16    7355
XP_006720823                                                           16    7355
XP_006720822                                                           16    7355
XP_005255044                                                           16    7355
XP_005255043                                                           16    7355
NP_006827                                                              15    9605
NP_001269576                                                           15    9605
NP_001027460                                                           15    9605
NP_001269577                                                           15    9605
NP_689936                                                              15    9605
>NP_001072990
          Length = 1306

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           S+ EALCV+
Sbjct: 297 SEDEALCVV 305
>NP_001257943
          Length = 1329

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           S+ EALCV+
Sbjct: 297 SEDEALCVV 305
>NP_004977
          Length = 1300

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           S+ EALCV+
Sbjct: 297 SEDEALCVV 305
>XP_006720204
          Length = 1298

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           S+ EALCV+
Sbjct: 297 SEDEALCVV 305
>XP_006720203
          Length = 1328

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           S+ EALCV+
Sbjct: 297 SEDEALCVV 305
>XP_006720202
          Length = 1329

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           S+ EALCV+
Sbjct: 297 SEDEALCVV 305
>XP_006720201
          Length = 1357

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           S+ EALCV+
Sbjct: 297 SEDEALCVV 305
>NP_001072989
          Length = 1357

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           S+ EALCV+
Sbjct: 297 SEDEALCVV 305
>NP_001186028
          Length = 1124

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SEALCVL 9
           SEALCV+
Sbjct: 737 SEALCVV 743
>NP_001186026
          Length = 1152

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SEALCVL 9
           SEALCV+
Sbjct: 765 SEALCVV 771
>NP_001186027
          Length = 1129

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SEALCVL 9
           SEALCV+
Sbjct: 742 SEALCVV 748
>NP_001186025
          Length = 1116

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SEALCVL 9
           SEALCV+
Sbjct: 729 SEALCVV 735
>NP_003924
          Length = 1187

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SEALCVL 9
           SEALCV+
Sbjct: 800 SEALCVV 806
>NP_001273393
          Length = 1169

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SEALCVL 9
           SEALCV+
Sbjct: 782 SEALCVV 788
>NP_004314
          Length = 345

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QSEALCVL 9
           Q+EALC L
Sbjct: 267 QAEALCKL 274
>NP_001165886
          Length = 230

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QSEALCVL 9
           Q+EALC L
Sbjct: 152 QAEALCKL 159
>NP_001157819
          Length = 668

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           SQSEAL +L
Sbjct: 93  SQSEALQIL 101
>NP_001157814
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           SQSEAL +L
Sbjct: 166 SQSEALQIL 174
>NP_001157816
          Length = 668

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           SQSEAL +L
Sbjct: 93  SQSEALQIL 101
>NP_056457
          Length = 668

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           SQSEAL +L
Sbjct: 93  SQSEALQIL 101
>NP_001157817
          Length = 668

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           SQSEAL +L
Sbjct: 93  SQSEALQIL 101
>NP_001157815
          Length = 668

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           SQSEAL +L
Sbjct: 93  SQSEALQIL 101
>NP_001157818
          Length = 668

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           SQSEAL +L
Sbjct: 93  SQSEALQIL 101
>NP_001191227
          Length = 261

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SQSEALCV 8
           SQS +LC+
Sbjct: 181 SQSSSLCI 188

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SQSEALCV 8
           SQS +LC+
Sbjct: 209 SQSSSLCI 216

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SQSEALCV 8
           SQS +LC+
Sbjct: 237 SQSTSLCI 244
>NP_689650
          Length = 261

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SQSEALCV 8
           SQS +LC+
Sbjct: 181 SQSSSLCI 188

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SQSEALCV 8
           SQS +LC+
Sbjct: 209 SQSSSLCI 216

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SQSEALCV 8
           SQS +LC+
Sbjct: 237 SQSTSLCI 244
>XP_005247400
          Length = 668

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           SQSEAL +L
Sbjct: 93  SQSEALQIL 101
>XP_005247399
          Length = 668

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           SQSEAL +L
Sbjct: 93  SQSEALQIL 101
>XP_006713644
          Length = 668

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           SQSEAL +L
Sbjct: 93  SQSEALQIL 101
>XP_006713643
          Length = 668

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           SQSEAL +L
Sbjct: 93  SQSEALQIL 101
>XP_006713642
          Length = 685

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           SQSEAL +L
Sbjct: 110 SQSEALQIL 118
>XP_005247398
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           SQSEAL +L
Sbjct: 166 SQSEALQIL 174
>XP_005247397
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           SQSEAL +L
Sbjct: 166 SQSEALQIL 174
>XP_005247396
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           SQSEAL +L
Sbjct: 166 SQSEALQIL 174
>XP_006713641
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           SQSEAL +L
Sbjct: 166 SQSEALQIL 174
>XP_006713640
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SQSEALCVL 9
           SQSEAL +L
Sbjct: 166 SQSEALQIL 174
>NP_003972
          Length = 620

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQSEALC 7
           SQ+EA+C
Sbjct: 230 SQNEAVC 236
>NP_955445
          Length = 606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQSEALC 7
           SQ+EA+C
Sbjct: 230 SQNEAVC 236
>NP_001254509
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQSEALC 7
           SQ+EA+C
Sbjct: 189 SQNEAVC 195
>XP_006720823
          Length = 562

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQSEALC 7
           SQ+EA+C
Sbjct: 230 SQNEAVC 236
>XP_006720822
          Length = 563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQSEALC 7
           SQ+EA+C
Sbjct: 230 SQNEAVC 236
>XP_005255044
          Length = 566

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQSEALC 7
           SQ+EA+C
Sbjct: 230 SQNEAVC 236
>XP_005255043
          Length = 626

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQSEALC 7
           SQ+EA+C
Sbjct: 230 SQNEAVC 236
>NP_006827
          Length = 2671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EALCVL 9
           EALCV+
Sbjct: 645 EALCVI 650
>NP_001269576
          Length = 224

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SQSEALCV 8
           SQS +LC+
Sbjct: 148 SQSHSLCL 155
>NP_001027460
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SQSEALCV 8
           SQS +LC+
Sbjct: 148 SQSHSLCL 155
>NP_001269577
          Length = 218

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SQSEALCV 8
           SQS +LC+
Sbjct: 124 SQSHSLCL 131
>NP_689936
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  QSEALCVL 9
          QS+ +C+L
Sbjct: 73 QSQLICIL 80
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.121    0.325 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 573,516
Number of extensions: 538
Number of successful extensions: 51
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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