Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_444256                                                              20     509
NP_444254                                                              20     509
NP_444253                                                              20     509
NP_444255                                                              20     509
XP_005247551                                                           20     509
XP_005247550                                                           20     509
XP_006713712                                                           20     509
XP_005247549                                                           20     509
NP_443137                                                              17    3301
NP_937816                                                              17    3301
NP_937817                                                              17    3301
NP_001129243                                                           17    3301
NP_002942                                                              17    3301
XP_006723915                                                           17    3301
XP_006723914                                                           17    3301
XP_005260548                                                           17    3301
XP_006723913                                                           17    3301
XP_006723912                                                           17    3301
XP_006712292                                                           17    3301
XP_005246323                                                           17    3301
XP_005246322                                                           17    3301
XP_006712291                                                           17    3301
XP_005246320                                                           17    3301
NP_001264044                                                           16    5631
NP_001243544                                                           16    7355
NP_064615                                                              16    7355
NP_001123564                                                           16    7355
NP_001123563                                                           16    7355
NP_001123562                                                           16    7355
NP_112584                                                              16    7355
NP_001185619                                                           16    7355
NP_001035754                                                           16    7355
XP_006721648                                                           16    7355
XP_005256867                                                           16    7355
XP_006721647                                                           16    7355
XP_006721646                                                           16    7355
NP_001360                                                              15    9605
NP_001612                                                              15    9605
NP_001159758                                                           15    9605
NP_064596                                                              15    9605
NP_001159761                                                           15    9605
NP_001159755                                                           15    9605
NP_001159760                                                           15    9605
NP_001159759                                                           15    9605
NP_690621                                                              15    9605
NP_690620                                                              15    9605
NP_690619                                                              15    9605
NP_055516                                                              15    9605
NP_055386                                                              15    9605
NP_001180418                                                           15    9605
NP_002812                                                              15    9605
NP_001257327                                                           15    9605
NP_001193856                                                           15    9605
XP_006715067                                                           15    9605
XP_005248319                                                           15    9605
XP_005270802                                                           15    9605
>NP_444256
          Length = 1794

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QQVDFRSV 9
           QQVDFRSV
Sbjct: 880 QQVDFRSV 887
>NP_444254
          Length = 1845

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QQVDFRSV 9
           QQVDFRSV
Sbjct: 880 QQVDFRSV 887
>NP_444253
          Length = 1914

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QQVDFRSV 9
           QQVDFRSV
Sbjct: 949 QQVDFRSV 956
>NP_444255
          Length = 1863

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QQVDFRSV 9
           QQVDFRSV
Sbjct: 949 QQVDFRSV 956
>XP_005247551
          Length = 1855

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QQVDFRSV 9
           QQVDFRSV
Sbjct: 890 QQVDFRSV 897
>XP_005247550
          Length = 1856

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QQVDFRSV 9
           QQVDFRSV
Sbjct: 959 QQVDFRSV 966
>XP_006713712
          Length = 1923

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QQVDFRSV 9
           QQVDFRSV
Sbjct: 959 QQVDFRSV 966
>XP_005247549
          Length = 1924

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QQVDFRSV 9
           QQVDFRSV
Sbjct: 959 QQVDFRSV 966
>NP_443137
          Length = 1092

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SQQVDFRS 8
          SQQ DFR+
Sbjct: 9  SQQTDFRA 16
>NP_937816
          Length = 602

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SQQVDFRSV 9
          S ++DFRSV
Sbjct: 2  SNELDFRSV 10
>NP_937817
          Length = 626

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SQQVDFRSV 9
          S ++DFRSV
Sbjct: 2  SNELDFRSV 10
>NP_001129243
          Length = 615

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQQVDFRSV 9
           SQQ D RS+
Sbjct: 140 SQQADLRSI 148
>NP_002942
          Length = 631

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQQVDFRSV 9
           SQQ D RS+
Sbjct: 172 SQQADLRSI 180
>XP_006723915
          Length = 615

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQQVDFRSV 9
           SQQ D RS+
Sbjct: 188 SQQADLRSI 196
>XP_006723914
          Length = 631

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQQVDFRSV 9
           SQQ D RS+
Sbjct: 188 SQQADLRSI 196
>XP_005260548
          Length = 647

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQQVDFRSV 9
           SQQ D RS+
Sbjct: 172 SQQADLRSI 180
>XP_006723913
          Length = 647

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQQVDFRSV 9
           SQQ D RS+
Sbjct: 188 SQQADLRSI 196
>XP_006723912
          Length = 663

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQQVDFRSV 9
           SQQ D RS+
Sbjct: 188 SQQADLRSI 196
>XP_006712292
          Length = 641

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SQQVDFRS 8
          SQQ DFR+
Sbjct: 9  SQQTDFRA 16
>XP_005246323
          Length = 1069

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SQQVDFRS 8
          SQQ DFR+
Sbjct: 9  SQQTDFRA 16
>XP_005246322
          Length = 1084

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SQQVDFRS 8
          SQQ DFR+
Sbjct: 9  SQQTDFRA 16
>XP_006712291
          Length = 1086

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SQQVDFRS 8
          SQQ DFR+
Sbjct: 9  SQQTDFRA 16
>XP_005246320
          Length = 1087

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SQQVDFRS 8
          SQQ DFR+
Sbjct: 9  SQQTDFRA 16
>NP_001264044
          Length = 4516

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    SQQVDFRSV 9
            S+Q+D++S+
Sbjct: 1920 SEQMDYKSI 1928
>NP_001243544
          Length = 123

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SQQVDFRS 8
          SQQ+ FRS
Sbjct: 86 SQQLGFRS 93
>NP_064615
          Length = 473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQQVDFR 7
           SQ++DFR
Sbjct: 189 SQELDFR 195
>NP_001123564
          Length = 457

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SQQVDFRSV 9
          S Q+DFR++
Sbjct: 47 SLQLDFRNI 55
>NP_001123563
          Length = 457

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SQQVDFRSV 9
          S Q+DFR++
Sbjct: 47 SLQLDFRNI 55
>NP_001123562
          Length = 523

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SQQVDFRSV 9
          S Q+DFR++
Sbjct: 47 SLQLDFRNI 55
>NP_112584
          Length = 523

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SQQVDFRSV 9
          S Q+DFR++
Sbjct: 47 SLQLDFRNI 55
>NP_001185619
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQQVDFR 7
           SQ++DFR
Sbjct: 189 SQELDFR 195
>NP_001035754
          Length = 794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SQQVDFR 7
           SQ++DFR
Sbjct: 189 SQELDFR 195
>XP_006721648
          Length = 446

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SQQVDFRSV 9
          S Q+DFR++
Sbjct: 47 SLQLDFRNI 55
>XP_005256867
          Length = 457

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SQQVDFRSV 9
          S Q+DFR++
Sbjct: 47 SLQLDFRNI 55
>XP_006721647
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SQQVDFRSV 9
          S Q+DFR++
Sbjct: 47 SLQLDFRNI 55
>XP_006721646
          Length = 542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SQQVDFRSV 9
          S Q+DFR++
Sbjct: 47 SLQLDFRNI 55
>NP_001360
          Length = 4624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    SQQVDFRSV 9
            S Q+DFR +
Sbjct: 2007 SDQMDFRGL 2015
>NP_001612
          Length = 848

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SQQVDFRSV 9
           S +VDFR +
Sbjct: 567 SGEVDFRDI 575
>NP_001159758
          Length = 434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SQQVDFRS 8
           +QQ+DF++
Sbjct: 306 NQQIDFQA 313
>NP_064596
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SQQVDFRS 8
           +QQ+DF++
Sbjct: 322 NQQIDFQA 329
>NP_001159761
          Length = 434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SQQVDFRS 8
           +QQ+DF++
Sbjct: 306 NQQIDFQA 313
>NP_001159755
          Length = 458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SQQVDFRS 8
           +QQ+DF++
Sbjct: 330 NQQIDFQA 337
>NP_001159760
          Length = 434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SQQVDFRS 8
           +QQ+DF++
Sbjct: 306 NQQIDFQA 313
>NP_001159759
          Length = 434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SQQVDFRS 8
           +QQ+DF++
Sbjct: 306 NQQIDFQA 313
>NP_690621
          Length = 1014

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   QQVDFR 7
           QQ+DFR
Sbjct: 783 QQLDFR 788
>NP_690620
          Length = 940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   QQVDFR 7
           QQ+DFR
Sbjct: 709 QQLDFR 714
>NP_690619
          Length = 1030

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   QQVDFR 7
           QQ+DFR
Sbjct: 799 QQLDFR 804
>NP_055516
          Length = 1056

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SQQVDFRS 8
           SQQ DF S
Sbjct: 218 SQQTDFPS 225
>NP_055386
          Length = 328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VDFRSV 9
           VDFRS+
Sbjct: 114 VDFRSI 119
>NP_001180418
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SQQVDFRS 8
           SQQ DF S
Sbjct: 218 SQQTDFPS 225
>NP_002812
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   QQVDFR 7
           QQ+DFR
Sbjct: 839 QQLDFR 844
>NP_001257327
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   QQVDFR 7
           QQ+DFR
Sbjct: 847 QQLDFR 852
>NP_001193856
          Length = 4707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    SQQVDFRSV 9
            S Q+DFR +
Sbjct: 2090 SDQMDFRGL 2098
>XP_006715067
          Length = 4707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    SQQVDFRSV 9
            S Q+DFR +
Sbjct: 2090 SDQMDFRGL 2098
>XP_005248319
          Length = 4609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    SQQVDFRSV 9
            S Q+DFR +
Sbjct: 1992 SDQMDFRGL 2000
>XP_005270802
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  VDFRSV 9
          VDFRS+
Sbjct: 86 VDFRSI 91
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.126    0.317 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 421,751
Number of extensions: 438
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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