Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              20     509
NP_671714                                                              20     509
XP_006715890                                                           20     509
XP_005250160                                                           20     509
XP_005250159                                                           20     509
NP_001254652                                                           17    4312
NP_001241646                                                           17    4312
NP_001135441                                                           17    4312
NP_001135442                                                           17    4312
NP_001341                                                              17    4312
XP_005275411                                                           17    4312
XP_005275275                                                           17    4312
XP_005259249                                                           17    4312
XP_005259248                                                           17    4312
XP_005248917                                                           17    4312
NP_001243757                                                           16    5631
NP_001269255                                                           16    5631
NP_001243756                                                           16    5631
NP_060045                                                              16    5631
NP_001091981                                                           16    5631
NP_001230881                                                           16    5631
NP_004511                                                              16    5631
NP_001230882                                                           16    5631
XP_005256628                                                           16    5631
XP_006721556                                                           16    5631
XP_005256626                                                           16    5631
NP_001278208                                                           16    7355
NP_001278207                                                           16    7355
NP_536723                                                              16    7355
NP_005868                                                              16    7355
NP_001005409                                                           16    7355
NP_001274433                                                           15    9605
NP_001269618                                                           15    9605
NP_076982                                                              15    9605
NP_001269619                                                           15    9605
NP_001269617                                                           15    9605
XP_005252259                                                           15    9605
XP_006717345                                                           15    9605
XP_005252255                                                           15    9605
XP_005252253                                                           15    9605
XP_005252252                                                           15    9605
XP_005252250                                                           15    9605
XP_005246870                                                           15    9605
XP_005246869                                                           15    9605
NP_003822                                                              15    9605
NP_001123917                                                           15    9605
NP_001274432                                                           15    9605
NP_006742                                                              15    9605
>NP_005742
          Length = 3907

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SQMLEMEVE 9
            SQMLEM+VE
Sbjct: 3131 SQMLEMQVE 3139
>NP_671714
          Length = 3899

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SQMLEMEVE 9
            SQMLEM+VE
Sbjct: 3123 SQMLEMQVE 3131
>XP_006715890
          Length = 3860

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SQMLEMEVE 9
            SQMLEM+VE
Sbjct: 3084 SQMLEMQVE 3092
>XP_005250160
          Length = 3939

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SQMLEMEVE 9
            SQMLEM+VE
Sbjct: 3163 SQMLEMQVE 3171
>XP_005250159
          Length = 3952

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SQMLEMEVE 9
            SQMLEM+VE
Sbjct: 3176 SQMLEMQVE 3184
>NP_001254652
          Length = 512

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  QMLEMEVE 9
          Q+LE+EVE
Sbjct: 27 QVLELEVE 34
>NP_001241646
          Length = 665

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQMLEMEVE 9
           SQ+ E+E+E
Sbjct: 489 SQLFELEIE 497
>NP_001135441
          Length = 740

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQMLEMEVE 9
           SQ+ E+E+E
Sbjct: 564 SQLFELEIE 572
>NP_001135442
          Length = 752

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQMLEMEVE 9
           SQ+ E+E+E
Sbjct: 576 SQLFELEIE 584
>NP_001341
          Length = 740

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQMLEMEVE 9
           SQ+ E+E+E
Sbjct: 564 SQLFELEIE 572
>XP_005275411
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQMLEMEVE 9
           SQ+ E+E+E
Sbjct: 196 SQLFELEIE 204
>XP_005275275
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQMLEMEVE 9
           SQ+ E+E+E
Sbjct: 196 SQLFELEIE 204
>XP_005259249
          Length = 512

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  QMLEMEVE 9
          Q+LE+EVE
Sbjct: 27 QVLELEVE 34
>XP_005259248
          Length = 520

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  QMLEMEVE 9
          Q+LE+EVE
Sbjct: 35 QVLELEVE 42
>XP_005248917
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQMLEMEVE 9
           SQ+ E+E+E
Sbjct: 196 SQLFELEIE 204
>NP_001243757
          Length = 511

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQMLEMEVE 9
           SQM +ME+E
Sbjct: 326 SQMRQMELE 334
>NP_001269255
          Length = 330

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQMLEMEVE 9
           SQM +ME+E
Sbjct: 145 SQMRQMELE 153
>NP_001243756
          Length = 511

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQMLEMEVE 9
           SQM +ME+E
Sbjct: 326 SQMRQMELE 334
>NP_060045
          Length = 1419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SQMLEMEVE 9
            SQM +ME+E
Sbjct: 1234 SQMRQMELE 1242
>NP_001091981
          Length = 744

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SQMLEME 7
           SQM+EME
Sbjct: 653 SQMVEME 659
>NP_001230881
          Length = 686

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SQMLEME 7
           SQM+EME
Sbjct: 595 SQMVEME 601
>NP_004511
          Length = 706

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SQMLEME 7
           SQM+EME
Sbjct: 615 SQMVEME 621
>NP_001230882
          Length = 687

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SQMLEME 7
           SQM+EME
Sbjct: 596 SQMVEME 602
>XP_005256628
          Length = 511

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQMLEMEVE 9
           SQM +ME+E
Sbjct: 326 SQMRQMELE 334
>XP_006721556
          Length = 1357

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SQMLEMEVE 9
            SQM +ME+E
Sbjct: 1172 SQMRQMELE 1180
>XP_005256626
          Length = 1388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SQMLEMEVE 9
            SQM +ME+E
Sbjct: 1203 SQMRQMELE 1211
>NP_001278208
          Length = 217

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQMLEMEVE 9
           S M+E EVE
Sbjct: 100 SNMMEREVE 108
>NP_001278207
          Length = 305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQMLEMEVE 9
           S M+E EVE
Sbjct: 188 SNMMEREVE 196
>NP_536723
          Length = 392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQMLEMEVE 9
           S M+E EVE
Sbjct: 275 SNMMEREVE 283
>NP_005868
          Length = 793

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQMLEMEVE 9
           S+ +EMEVE
Sbjct: 320 SEEVEMEVE 328
>NP_001005409
          Length = 728

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SQMLEMEVE 9
           S+ +EMEVE
Sbjct: 255 SEEVEMEVE 263
>NP_001274433
          Length = 1084

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SQMLEMEVE 9
          +QM  MEVE
Sbjct: 69 AQMQRMEVE 77
>NP_001269618
          Length = 781

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQMLEMEVE 9
           SQML  EV+
Sbjct: 561 SQMLSKEVD 569
>NP_076982
          Length = 854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQMLEMEVE 9
           SQML  EV+
Sbjct: 634 SQMLSKEVD 642
>NP_001269619
          Length = 786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQMLEMEVE 9
           SQML  EV+
Sbjct: 566 SQMLSKEVD 574
>NP_001269617
          Length = 853

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQMLEMEVE 9
           SQML  EV+
Sbjct: 633 SQMLSKEVD 641
>XP_005252259
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQMLEMEVE 9
           SQML  EV+
Sbjct: 335 SQMLSKEVD 343
>XP_006717345
          Length = 781

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQMLEMEVE 9
           SQML  EV+
Sbjct: 561 SQMLSKEVD 569
>XP_005252255
          Length = 786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQMLEMEVE 9
           SQML  EV+
Sbjct: 566 SQMLSKEVD 574
>XP_005252253
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQMLEMEVE 9
           SQML  EV+
Sbjct: 595 SQMLSKEVD 603
>XP_005252252
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQMLEMEVE 9
           SQML  EV+
Sbjct: 596 SQMLSKEVD 604
>XP_005252250
          Length = 824

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQMLEMEVE 9
           SQML  EV+
Sbjct: 604 SQMLSKEVD 612
>XP_005246870
          Length = 1252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQMLEMEVE 9
           +QM  MEVE
Sbjct: 222 AQMQRMEVE 230
>XP_005246869
          Length = 1255

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQMLEMEVE 9
           +QM  MEVE
Sbjct: 222 AQMQRMEVE 230
>NP_003822
          Length = 519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SQMLEMEVE 9
          +QML+ME +
Sbjct: 81 AQMLQMEYD 89
>NP_001123917
          Length = 1259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQMLEMEVE 9
           +QM  MEVE
Sbjct: 222 AQMQRMEVE 230
>NP_001274432
          Length = 1237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQMLEMEVE 9
           +QM  MEVE
Sbjct: 222 AQMQRMEVE 230
>NP_006742
          Length = 1256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQMLEMEVE 9
           +QM  MEVE
Sbjct: 222 AQMQRMEVE 230
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.301    0.114    0.248 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 449,469
Number of extensions: 635
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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