Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              17    2528
NP_008920                                                              17    2528
XP_006726508                                                           17    2528
XP_006726506                                                           17    2528
XP_005271621                                                           17    2528
XP_006718907                                                           17    2528
XP_006718906                                                           17    2528
XP_005271619                                                           17    2528
XP_005271618                                                           17    2528
XP_006715892                                                           17    2528
XP_006715891                                                           17    2528
XP_005250161                                                           17    2528
XP_005250142                                                           17    2528
XP_005250141                                                           17    2528
NP_001135777                                                           16    5631
NP_057727                                                              16    5631
NP_067645                                                              16    7355
NP_001155856                                                           15    9605
NP_004714                                                              15    9605
NP_001155855                                                           15    9605
NP_003964                                                              15    9605
NP_001030168                                                           15    9605
NP_001078853                                                           15    9605
NP_851853                                                              15    9605
NP_056117                                                              15    9605
NP_066383                                                              15    9605
NP_001254526                                                           15    9605
XP_006723427                                                           15    9605
XP_006723182                                                           15    9605
XP_006717549                                                           15    9605
XP_006717548                                                           15    9605
XP_006717547                                                           15    9605
XP_006711689                                                           15    9605
XP_006711688                                                           15    9605
XP_006711687                                                           15    9605
XP_006711686                                                           15    9605
XP_005245651                                                           15    9605
XP_005245650                                                           15    9605
XP_005245649                                                           15    9605
XP_006711685                                                           15    9605
XP_005245648                                                           15    9605
XP_005245647                                                           15    9605
XP_005245646                                                           15    9605
XP_005245645                                                           15    9605
XP_005245644                                                           15    9605
>NP_000042
          Length = 3056

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SQKSALLKL 9
           SQKS LLKL
Sbjct: 475 SQKSDLLKL 483
>NP_008920
          Length = 803

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   SQKSALLKL 9
           S+KSAL+KL
Sbjct: 609 SKKSALIKL 617
>XP_006726508
          Length = 396

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   SQKSALLKL 9
           S+KSAL+KL
Sbjct: 302 SKKSALIKL 310
>XP_006726506
          Length = 496

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   SQKSALLKL 9
           S+KSAL+KL
Sbjct: 302 SKKSALIKL 310
>XP_005271621
          Length = 2708

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SQKSALLKL 9
           SQKS LLKL
Sbjct: 127 SQKSDLLKL 135
>XP_006718907
          Length = 3050

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SQKSALLKL 9
           SQKS LLKL
Sbjct: 475 SQKSDLLKL 483
>XP_006718906
          Length = 3056

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SQKSALLKL 9
           SQKS LLKL
Sbjct: 475 SQKSDLLKL 483
>XP_005271619
          Length = 3056

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SQKSALLKL 9
           SQKS LLKL
Sbjct: 475 SQKSDLLKL 483
>XP_005271618
          Length = 3056

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SQKSALLKL 9
           SQKS LLKL
Sbjct: 475 SQKSDLLKL 483
>XP_006715892
          Length = 520

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   SQKSALLKL 9
           S+KSAL+KL
Sbjct: 326 SKKSALIKL 334
>XP_006715891
          Length = 703

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   SQKSALLKL 9
           S+KSAL+KL
Sbjct: 609 SKKSALIKL 617
>XP_005250161
          Length = 728

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   SQKSALLKL 9
           S+KSAL+KL
Sbjct: 609 SKKSALIKL 617
>XP_005250142
          Length = 728

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   SQKSALLKL 9
           S+KSAL+KL
Sbjct: 609 SKKSALIKL 617
>XP_005250141
          Length = 803

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   SQKSALLKL 9
           S+KSAL+KL
Sbjct: 609 SKKSALIKL 617
>NP_001135777
          Length = 317

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   SQKSALLK 8
           SQKSAL K
Sbjct: 101 SQKSALTK 108
>NP_057727
          Length = 317

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   SQKSALLK 8
           SQKSAL K
Sbjct: 101 SQKSALTK 108
>NP_067645
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SQKSALLK 8
           SQKS L+K
Sbjct: 356 SQKSGLIK 363
>NP_001155856
          Length = 985

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QKSALLK 8
           QK+ALLK
Sbjct: 94  QKAALLK 100
>NP_004714
          Length = 958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  QKSALLK 8
          QK+ALLK
Sbjct: 67 QKAALLK 73
>NP_001155855
          Length = 986

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QKSALLK 8
           QK+ALLK
Sbjct: 94  QKAALLK 100
>NP_003964
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QKSALLK 8
           QK+ALLK
Sbjct: 131 QKAALLK 137
>NP_001030168
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QKSALLK 8
           QK+ALLK
Sbjct: 131 QKAALLK 137
>NP_001078853
          Length = 437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SQKSALLK 8
           SQ+SALL+
Sbjct: 255 SQRSALLQ 262

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SQKSALLK 8
           SQ+SALL+
Sbjct: 339 SQRSALLQ 346
>NP_851853
          Length = 503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QKSALLKL 9
           QK+ALL+L
Sbjct: 265 QKAALLEL 272
>NP_056117
          Length = 633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SQKSALLK 8
           SQ+S LLK
Sbjct: 306 SQRSTLLK 313
>NP_066383
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QKSALLK 8
           +KSALLK
Sbjct: 335 EKSALLK 341
>NP_001254526
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QKSALLK 8
           +KSALLK
Sbjct: 335 EKSALLK 341
>XP_006723427
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SQKSALLK 8
           SQ+SALL+
Sbjct: 292 SQRSALLQ 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SQKSALLK 8
           SQ+SALL+
Sbjct: 376 SQRSALLQ 383
>XP_006723182
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SQKSALLK 8
           SQ+S LLK
Sbjct: 306 SQRSTLLK 313
>XP_006717549
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QKSALLK 8
           +KSALLK
Sbjct: 335 EKSALLK 341
>XP_006717548
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QKSALLK 8
           +KSALLK
Sbjct: 335 EKSALLK 341
>XP_006717547
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QKSALLK 8
           +KSALLK
Sbjct: 335 EKSALLK 341
>XP_006711689
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  QKSALLK 8
          QK+ALLK
Sbjct: 18 QKAALLK 24
>XP_006711688
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  QKSALLK 8
          QK+ALLK
Sbjct: 18 QKAALLK 24
>XP_006711687
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  QKSALLK 8
          QK+ALLK
Sbjct: 18 QKAALLK 24
>XP_006711686
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  QKSALLK 8
          QK+ALLK
Sbjct: 18 QKAALLK 24
>XP_005245651
          Length = 969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  QKSALLK 8
          QK+ALLK
Sbjct: 67 QKAALLK 73
>XP_005245650
          Length = 969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  QKSALLK 8
          QK+ALLK
Sbjct: 67 QKAALLK 73
>XP_005245649
          Length = 969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  QKSALLK 8
          QK+ALLK
Sbjct: 67 QKAALLK 73
>XP_006711685
          Length = 979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  QKSALLK 8
          QK+ALLK
Sbjct: 77 QKAALLK 83
>XP_005245648
          Length = 981

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  QKSALLK 8
          QK+ALLK
Sbjct: 79 QKAALLK 85
>XP_005245647
          Length = 981

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  QKSALLK 8
          QK+ALLK
Sbjct: 79 QKAALLK 85
>XP_005245646
          Length = 988

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  QKSALLK 8
          QK+ALLK
Sbjct: 86 QKAALLK 92
>XP_005245645
          Length = 995

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QKSALLK 8
           QK+ALLK
Sbjct: 94  QKAALLK 100
>XP_005245644
          Length = 996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QKSALLK 8
           QK+ALLK
Sbjct: 94  QKAALLK 100
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.305    0.117    0.252 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 298,413
Number of extensions: 506
Number of successful extensions: 47
Number of sequences better than 10000.0: 45
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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