Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              20     390
NP_001263689                                                           20     390
NP_001119584                                                           20     390
NP_001119586                                                           20     390
NP_001263625                                                           20     390
NP_001119590                                                           20     390
NP_001263690                                                           20     390
NP_001119585                                                           20     390
NP_001263624                                                           20     390
NP_001119588                                                           20     390
NP_001119587                                                           20     390
NP_001119589                                                           20     390
NP_001263627                                                           20     390
NP_001263628                                                           20     390
NP_001263626                                                           20     390
NP_002968                                                              19     869
XP_005246814                                                           19     869
NP_000876                                                              18    1935
NP_001157570                                                           17    4312
NP_004376                                                              17    4312
NP_443173                                                              17    4312
NP_001108451                                                           16    5631
NP_001108454                                                           16    5631
NP_003713                                                              16    5631
NP_001108450                                                           16    5631
NP_001108452                                                           16    5631
NP_001108453                                                           16    5631
NP_006260                                                              16    5631
NP_037483                                                              16    5631
XP_005247903                                                           16    5631
XP_005247901                                                           16    5631
XP_005247900                                                           16    5631
NP_001229625                                                           16    5631
NP_000766                                                              16    7355
NP_631901                                                              16    7355
NP_683684                                                              16    7355
NP_689594                                                              16    7355
XP_006712319                                                           16    7355
NP_001186073                                                           16    7355
NP_001004704                                                           16    7355
NP_060311                                                              15    9605
NP_056349                                                              15    9605
NP_001193583                                                           15    9605
NP_006303                                                              15    9605
NP_001070729                                                           15    9605
NP_001006623                                                           15    9605
NP_057315                                                              15    9605
NP_036516                                                              15    9605
NP_758953                                                              15    9605
XP_005260259                                                           15    9605
XP_005258045                                                           15    9605
XP_005267412                                                           15    9605
XP_005267411                                                           15    9605
XP_005270784                                                           15    9605
XP_005270783                                                           15    9605
XP_005270782                                                           15    9605
NP_001004696                                                           15    9605
NP_001004697                                                           15    9605
NP_001005234                                                           15    9605
NP_001004694                                                           15    9605
>NP_000537
          Length = 393

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SQHMTEVV 8
           SQHMTEVV
Sbjct: 166 SQHMTEVV 173
>NP_001263689
          Length = 354

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SQHMTEVV 8
           SQHMTEVV
Sbjct: 127 SQHMTEVV 134
>NP_001119584
          Length = 393

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SQHMTEVV 8
           SQHMTEVV
Sbjct: 166 SQHMTEVV 173
>NP_001119586
          Length = 341

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SQHMTEVV 8
           SQHMTEVV
Sbjct: 166 SQHMTEVV 173
>NP_001263625
          Length = 302

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SQHMTEVV 8
           SQHMTEVV
Sbjct: 127 SQHMTEVV 134
>NP_001119590
          Length = 354

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SQHMTEVV 8
           SQHMTEVV
Sbjct: 127 SQHMTEVV 134
>NP_001263690
          Length = 354

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SQHMTEVV 8
           SQHMTEVV
Sbjct: 127 SQHMTEVV 134
>NP_001119585
          Length = 346

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SQHMTEVV 8
           SQHMTEVV
Sbjct: 166 SQHMTEVV 173
>NP_001263624
          Length = 307

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SQHMTEVV 8
           SQHMTEVV
Sbjct: 127 SQHMTEVV 134
>NP_001119588
          Length = 209

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  SQHMTEVV 8
          SQHMTEVV
Sbjct: 34 SQHMTEVV 41
>NP_001119587
          Length = 261

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  SQHMTEVV 8
          SQHMTEVV
Sbjct: 34 SQHMTEVV 41
>NP_001119589
          Length = 214

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  SQHMTEVV 8
          SQHMTEVV
Sbjct: 34 SQHMTEVV 41
>NP_001263627
          Length = 182

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  SQHMTEVV 8
          SQHMTEVV
Sbjct: 7  SQHMTEVV 14
>NP_001263628
          Length = 187

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  SQHMTEVV 8
          SQHMTEVV
Sbjct: 7  SQHMTEVV 14
>NP_001263626
          Length = 234

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  SQHMTEVV 8
          SQHMTEVV
Sbjct: 7  SQHMTEVV 14
>NP_002968
          Length = 1977

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    SQHMTEVV 8
            SQHMTEV+
Sbjct: 1529 SQHMTEVL 1536
>XP_005246814
          Length = 1988

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    SQHMTEVV 8
            SQHMTEV+
Sbjct: 1540 SQHMTEVL 1547
>NP_000876
          Length = 1032

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   SQHMTEVV 8
           SQH TEVV
Sbjct: 262 SQHTTEVV 269
>NP_001157570
          Length = 1642

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQHMTEVVL 9
           SQH TE+ L
Sbjct: 647 SQHRTEIEL 655
>NP_004376
          Length = 3396

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQHMTEVVL 9
           SQH TE+ L
Sbjct: 647 SQHRTEIEL 655
>NP_443173
          Length = 640

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQHMTEVVL 9
           S+H+TE +L
Sbjct: 429 SEHLTESIL 437
>NP_001108451
          Length = 487

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SQHMTEVV 8
           ++H+TEVV
Sbjct: 234 AEHVTEVV 241
>NP_001108454
          Length = 393

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SQHMTEVV 8
           ++H+TEVV
Sbjct: 140 AEHVTEVV 147
>NP_003713
          Length = 680

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SQHMTEVV 8
           ++H+TEVV
Sbjct: 234 AEHVTEVV 241
>NP_001108450
          Length = 555

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SQHMTEVV 8
           ++H+TEVV
Sbjct: 234 AEHVTEVV 241
>NP_001108452
          Length = 586

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SQHMTEVV 8
           ++H+TEVV
Sbjct: 140 AEHVTEVV 147
>NP_001108453
          Length = 461

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SQHMTEVV 8
           ++H+TEVV
Sbjct: 140 AEHVTEVV 147
>NP_006260
          Length = 2156

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QHMTEVV 8
           QH+TEV+
Sbjct: 185 QHLTEVM 191
>NP_037483
          Length = 535

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   SQHMTEVVL 9
           +QH TE+++
Sbjct: 151 NQHQTEMII 159
>XP_005247903
          Length = 483

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SQHMTEVV 8
           ++H+TEVV
Sbjct: 234 AEHVTEVV 241
>XP_005247901
          Length = 663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SQHMTEVV 8
           ++H+TEVV
Sbjct: 217 AEHVTEVV 224
>XP_005247900
          Length = 676

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SQHMTEVV 8
           ++H+TEVV
Sbjct: 234 AEHVTEVV 241
>NP_001229625
          Length = 143

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  QHMTEVVL 9
          QH+TE +L
Sbjct: 79 QHLTEKIL 86
>NP_000766
          Length = 502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SQHMTEVV 8
           +QH+TE +
Sbjct: 163 AQHLTEAI 170
>NP_631901
          Length = 454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HMTEVVL 9
           H+T+VVL
Sbjct: 377 HLTQVVL 383
>NP_683684
          Length = 465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HMTEVVL 9
           H+T+VVL
Sbjct: 388 HLTQVVL 394
>NP_689594
          Length = 3549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SQHMTEV 7
            +QH+TEV
Sbjct: 2577 NQHITEV 2583
>XP_006712319
          Length = 3308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SQHMTEV 7
            +QH+TEV
Sbjct: 2336 NQHITEV 2342
>NP_001186073
          Length = 3327

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SQHMTEV 7
            +QH+TEV
Sbjct: 2355 NQHITEV 2361
>NP_001004704
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SQHMTEVVL 9
           S H+T VVL
Sbjct: 239 SSHLTVVVL 247
>NP_060311
          Length = 166

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2  QHMTE 6
          QHMTE
Sbjct: 95 QHMTE 99
>NP_056349
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SQHMTE 6
           SQH+TE
Sbjct: 474 SQHITE 479
>NP_001193583
          Length = 2504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    SQHMTEVV 8
            +QH++EV+
Sbjct: 2123 AQHISEVI 2130
>NP_006303
          Length = 2514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    SQHMTEVV 8
            +QH++EV+
Sbjct: 2133 AQHISEVI 2140
>NP_001070729
          Length = 2458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    SQHMTEVV 8
            +QH++EV+
Sbjct: 2123 AQHISEVI 2130
>NP_001006623
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HMTEVVL 9
           H++EVVL
Sbjct: 266 HLSEVVL 272
>NP_057315
          Length = 527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQHMTEVVL 9
           S+HMT+ V+
Sbjct: 294 SRHMTQEVV 302
>NP_036516
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SQHMTEVVL 9
          S HM EVV+
Sbjct: 7  SVHMEEVVV 15
>NP_758953
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   QHMTEV 7
           QH+TE+
Sbjct: 254 QHLTEI 259
>XP_005260259
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SQHMTEVVL 9
          S HM EVV+
Sbjct: 7  SVHMEEVVV 15
>XP_005258045
          Length = 498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SQHMTEVVL 9
           S+HMT+ V+
Sbjct: 294 SRHMTQEVV 302
>XP_005267412
          Length = 378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   QHMTEV 7
           QH+TE+
Sbjct: 210 QHLTEI 215
>XP_005267411
          Length = 410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   QHMTEV 7
           QH+TE+
Sbjct: 242 QHLTEI 247
>XP_005270784
          Length = 902

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SQHMTE 6
           SQH+TE
Sbjct: 474 SQHITE 479
>XP_005270783
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SQHMTE 6
           SQH+TE
Sbjct: 474 SQHITE 479
>XP_005270782
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SQHMTE 6
           SQH+TE
Sbjct: 474 SQHITE 479
>NP_001004696
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SQHMTEVVL 9
           S H+T V+L
Sbjct: 274 SSHLTVVIL 282
>NP_001004697
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SQHMTEVVL 9
           S H+T V+L
Sbjct: 246 SSHLTVVIL 254
>NP_001005234
          Length = 324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SQHMTEVVL 9
           S H+T V+L
Sbjct: 242 SSHLTVVIL 250
>NP_001004694
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SQHMTEVVL 9
           S H+T V+L
Sbjct: 246 SSHLTVVIL 254
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.120    0.307 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 522,156
Number of extensions: 664
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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