Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001077081                                                           18    1482
NP_001013641                                                           18    1482
NP_001034663                                                           17    2528
NP_064504                                                              17    4312
NP_078901                                                              17    4312
XP_005250558                                                           17    4312
NP_003945                                                              16    5631
NP_778227                                                              16    5631
NP_004752                                                              16    7355
NP_001230667                                                           16    7355
XP_005275492                                                           16    7355
XP_005275491                                                           16    7355
XP_005275332                                                           16    7355
XP_005275331                                                           16    7355
XP_005275330                                                           16    7355
XP_005275063                                                           16    7355
XP_005275062                                                           16    7355
XP_005275061                                                           16    7355
XP_005272907                                                           16    7355
XP_005272906                                                           16    7355
XP_005272905                                                           16    7355
XP_005249315                                                           16    7355
XP_005249314                                                           16    7355
XP_005249313                                                           16    7355
XP_005276144                                                           16    7355
NP_001578                                                              15    9605
NP_000267                                                              15    9605
NP_001269435                                                           15    9605
NP_005531                                                              15    9605
NP_001600                                                              15    9605
NP_115946                                                              15    9605
NP_037521                                                              15    9605
NP_001095118                                                           15    9605
NP_001277255                                                           15    9605
NP_001277254                                                           15    9605
NP_001170937                                                           15    9605
NP_005482                                                              15    9605
XP_005274693                                                           15    9605
XP_006724866                                                           15    9605
XP_006724865                                                           15    9605
XP_005262479                                                           15    9605
XP_005262478                                                           15    9605
XP_006724824                                                           15    9605
XP_006724823                                                           15    9605
XP_005252323                                                           15    9605
XP_005252322                                                           15    9605
XP_005252321                                                           15    9605
XP_005252320                                                           15    9605
XP_006715772                                                           15    9605
XP_006710684                                                           15    9605
XP_006710683                                                           15    9605
XP_006710682                                                           15    9605
XP_005270893                                                           15    9605
XP_005270890                                                           15    9605
NP_001092272                                                           15    9605
NP_115547                                                              15    9605
>NP_001077081
          Length = 220

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  NYSQSEAL 9
          NY QSEAL
Sbjct: 5  NYQQSEAL 12
>NP_001013641
          Length = 373

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  NYSQSEAL 9
          NY QSEAL
Sbjct: 5  NYQQSEAL 12
>NP_001034663
          Length = 626

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNYSQSEAL 9
           SNY+Q+E L
Sbjct: 615 SNYAQAEVL 623
>NP_064504
          Length = 902

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   NYSQSE 7
           NYSQSE
Sbjct: 97  NYSQSE 102
>NP_078901
          Length = 699

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   NYSQSE 7
           NYSQSE
Sbjct: 97  NYSQSE 102
>XP_005250558
          Length = 1024

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   NYSQSE 7
           NYSQSE
Sbjct: 97  NYSQSE 102
>NP_003945
          Length = 947

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   YSQSEAL 9
           YSQSE+L
Sbjct: 108 YSQSESL 114
>NP_778227
          Length = 348

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  SNYSQSEAL 9
          +N+SQ+EA+
Sbjct: 3  NNFSQAEAV 11
>NP_004752
          Length = 777

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NYSQSEAL 9
           NYSQS  L
Sbjct: 393 NYSQSREL 400
>NP_001230667
          Length = 695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NYSQSEAL 9
           NYSQS  L
Sbjct: 311 NYSQSREL 318
>XP_005275492
          Length = 734

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NYSQSEAL 9
           NYSQS  L
Sbjct: 311 NYSQSREL 318
>XP_005275491
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NYSQSEAL 9
           NYSQS  L
Sbjct: 393 NYSQSREL 400
>XP_005275332
          Length = 734

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NYSQSEAL 9
           NYSQS  L
Sbjct: 311 NYSQSREL 318
>XP_005275331
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NYSQSEAL 9
           NYSQS  L
Sbjct: 393 NYSQSREL 400
>XP_005275330
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NYSQSEAL 9
           NYSQS  L
Sbjct: 393 NYSQSREL 400
>XP_005275063
          Length = 734

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NYSQSEAL 9
           NYSQS  L
Sbjct: 311 NYSQSREL 318
>XP_005275062
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NYSQSEAL 9
           NYSQS  L
Sbjct: 393 NYSQSREL 400
>XP_005275061
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NYSQSEAL 9
           NYSQS  L
Sbjct: 393 NYSQSREL 400
>XP_005272907
          Length = 734

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NYSQSEAL 9
           NYSQS  L
Sbjct: 311 NYSQSREL 318
>XP_005272906
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NYSQSEAL 9
           NYSQS  L
Sbjct: 393 NYSQSREL 400
>XP_005272905
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NYSQSEAL 9
           NYSQS  L
Sbjct: 393 NYSQSREL 400
>XP_005249315
          Length = 734

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NYSQSEAL 9
           NYSQS  L
Sbjct: 311 NYSQSREL 318
>XP_005249314
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NYSQSEAL 9
           NYSQS  L
Sbjct: 393 NYSQSREL 400
>XP_005249313
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NYSQSEAL 9
           NYSQS  L
Sbjct: 393 NYSQSREL 400
>XP_005276144
          Length = 348

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  NYSQSEAL 9
          N SQSEAL
Sbjct: 36 NPSQSEAL 43
>NP_001578
          Length = 893

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNYSQSEAL 9
           SN+S +EAL
Sbjct: 775 SNHSVAEAL 783
>NP_000267
          Length = 901

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNYSQSEAL 9
           SN+S +EAL
Sbjct: 783 SNHSVAEAL 791
>NP_001269435
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNYSQSEA 8
           S+YS SEA
Sbjct: 572 SSYSPSEA 579
>NP_005531
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNYSQSEAL 9
           SN+S +EAL
Sbjct: 798 SNHSVAEAL 806
>NP_001600
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  SNYSQSEAL 9
          S  SQSEAL
Sbjct: 33 SKSSQSEAL 41
>NP_115946
          Length = 1042

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   YSQSEAL 9
           Y QSEAL
Sbjct: 875 YHQSEAL 881
>NP_037521
          Length = 1359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NYSQSEAL 9
           +YS++EAL
Sbjct: 563 DYSEAEAL 570
>NP_001095118
          Length = 1332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NYSQSEAL 9
           +YS++EAL
Sbjct: 563 DYSEAEAL 570
>NP_001277255
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   YSQSEAL 9
           Y QSEAL
Sbjct: 420 YHQSEAL 426
>NP_001277254
          Length = 1004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   YSQSEAL 9
           Y QSEAL
Sbjct: 875 YHQSEAL 881
>NP_001170937
          Length = 749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNYSQSEA 8
           S+YS SEA
Sbjct: 704 SSYSTSEA 711
>NP_005482
          Length = 774

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNYSQSEA 8
           S+YS SEA
Sbjct: 729 SSYSTSEA 736
>XP_005274693
          Length = 749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNYSQSEA 8
           S+YS SEA
Sbjct: 704 SSYSTSEA 711
>XP_006724866
          Length = 749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNYSQSEA 8
           S+YS SEA
Sbjct: 704 SSYSTSEA 711
>XP_006724865
          Length = 774

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNYSQSEA 8
           S+YS SEA
Sbjct: 729 SSYSTSEA 736
>XP_005262479
          Length = 744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNYSQSEAL 9
           SN+S +EAL
Sbjct: 626 SNHSVAEAL 634
>XP_005262478
          Length = 835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNYSQSEAL 9
           SN+S +EAL
Sbjct: 717 SNHSVAEAL 725
>XP_006724824
          Length = 890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNYSQSEAL 9
           SN+S +EAL
Sbjct: 772 SNHSVAEAL 780
>XP_006724823
          Length = 898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNYSQSEAL 9
           SN+S +EAL
Sbjct: 780 SNHSVAEAL 788
>XP_005252323
          Length = 635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NYSQSEAL 9
           N+S SEAL
Sbjct: 412 NFSLSEAL 419
>XP_005252322
          Length = 690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NYSQSEAL 9
           N+S SEAL
Sbjct: 499 NFSLSEAL 506
>XP_005252321
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NYSQSEAL 9
           N+S SEAL
Sbjct: 473 NFSLSEAL 480
>XP_005252320
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NYSQSEAL 9
           N+S SEAL
Sbjct: 499 NFSLSEAL 506
>XP_006715772
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NYSQSEAL 9
           +YS++EAL
Sbjct: 563 DYSEAEAL 570
>XP_006710684
          Length = 794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNYSQSEAL 9
           SN+S +EAL
Sbjct: 679 SNHSVAEAL 687
>XP_006710683
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNYSQSEAL 9
           SN+S +EAL
Sbjct: 578 SNHSVAEAL 586
>XP_006710682
          Length = 720

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNYSQSEAL 9
           SN+S +EAL
Sbjct: 605 SNHSVAEAL 613
>XP_005270893
          Length = 749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNYSQSEAL 9
           SN+S +EAL
Sbjct: 634 SNHSVAEAL 642
>XP_005270890
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNYSQSEAL 9
           SN+S +EAL
Sbjct: 796 SNHSVAEAL 804
>NP_001092272
          Length = 722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NYSQSEAL 9
           N+S SEAL
Sbjct: 499 NFSLSEAL 506
>NP_115547
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NYSQSEAL 9
           N+S SEAL
Sbjct: 499 NFSLSEAL 506
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.283   0.0983    0.224 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 456,067
Number of extensions: 563
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.8 bits)
S2: 28 (15.4 bits)

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