Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              20     509
NP_001087241                                                           20     509
XP_006714101                                                           20     509
XP_005265799                                                           20     509
XP_005265798                                                           20     509
XP_005265797                                                           20     509
NP_851322                                                              17    3301
NP_001035545                                                           17    4312
NP_001314                                                              16    5631
NP_005273                                                              16    5631
NP_001139317                                                           16    7355
NP_598334                                                              16    7355
NP_002932                                                              16    7355
NP_001276968                                                           16    7355
NP_001276969                                                           16    7355
NP_001122401                                                           16    7355
NP_002933                                                              16    7355
NP_071765                                                              16    7355
NP_817089                                                              16    7355
XP_005265887                                                           16    7355
XP_006713342                                                           16    7355
XP_006713341                                                           16    7355
XP_006713340                                                           16    7355
XP_006713339                                                           16    7355
NP_004937                                                              16    7355
NP_039225                                                              15    9605
NP_115604                                                              15    9605
XP_005275582                                                           15    9605
XP_005275581                                                           15    9605
XP_005275423                                                           15    9605
XP_005275422                                                           15    9605
XP_005275288                                                           15    9605
XP_005275287                                                           15    9605
XP_005275147                                                           15    9605
XP_005275146                                                           15    9605
XP_005274992                                                           15    9605
XP_005274991                                                           15    9605
XP_005272846                                                           15    9605
XP_005272845                                                           15    9605
XP_005274901                                                           15    9605
XP_005274900                                                           15    9605
XP_005249059                                                           15    9605
XP_005249058                                                           15    9605
XP_001717126                                                           15    9605
>NP_000213
          Length = 976

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SNSIYVFV 8
           SNSIYVFV
Sbjct: 104 SNSIYVFV 111
>NP_001087241
          Length = 972

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SNSIYVFV 8
           SNSIYVFV
Sbjct: 104 SNSIYVFV 111
>XP_006714101
          Length = 526

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SNSIYVFV 8
           SNSIYVFV
Sbjct: 104 SNSIYVFV 111
>XP_005265799
          Length = 973

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SNSIYVFV 8
           SNSIYVFV
Sbjct: 104 SNSIYVFV 111
>XP_005265798
          Length = 976

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SNSIYVFV 8
           SNSIYVFV
Sbjct: 104 SNSIYVFV 111
>XP_005265797
          Length = 977

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SNSIYVFV 8
           SNSIYVFV
Sbjct: 104 SNSIYVFV 111
>NP_851322
          Length = 724

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SNSIYVFVI 9
           SN +YVF++
Sbjct: 226 SNYLYVFIL 234
>NP_001035545
          Length = 832

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SNSIYVFVI 9
           SNS YV V+
Sbjct: 240 SNSFYVVVV 248
>NP_001314
          Length = 149

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  SNSIYVF 7
          SNSIY F
Sbjct: 63 SNSIYYF 69
>NP_005273
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SIYVFVI 9
          S+Y+FVI
Sbjct: 22 SLYIFVI 28
>NP_001139317
          Length = 1551

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   NSIYVFVI 9
           N+IY+F++
Sbjct: 591 NAIYLFLV 598
>NP_598334
          Length = 1606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   NSIYVFVI 9
           N+IY+F++
Sbjct: 591 NAIYLFLV 598
>NP_002932
          Length = 1651

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   NSIYVFVI 9
           N+IY+F++
Sbjct: 627 NAIYLFLV 634
>NP_001276968
          Length = 1382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   NSIYVFVI 9
           N+IY+F++
Sbjct: 592 NTIYLFMV 599
>NP_001276969
          Length = 1443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   NSIYVFVI 9
           N+IY+F++
Sbjct: 592 NTIYLFMV 599
>NP_001122401
          Length = 1394

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   NSIYVFVI 9
           N+IY+F++
Sbjct: 604 NTIYLFMV 611
>NP_002933
          Length = 1378

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   NSIYVFVI 9
           N+IY+F++
Sbjct: 588 NTIYLFMV 595
>NP_071765
          Length = 1386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   NSIYVFVI 9
           N+IY+F++
Sbjct: 622 NTIYLFLV 629
>NP_817089
          Length = 832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SNSIYVFVI 9
           +NS YV +I
Sbjct: 462 NNSFYVIII 470
>XP_005265887
          Length = 939

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SNSIYVFV 8
           ++S+YVFV
Sbjct: 220 THSLYVFV 227
>XP_006713342
          Length = 1205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   NSIYVFVI 9
           N+IY+F++
Sbjct: 608 NTIYLFMV 615
>XP_006713341
          Length = 1600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   NSIYVFVI 9
           N+IY+F++
Sbjct: 576 NAIYLFLV 583
>XP_006713340
          Length = 1615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   NSIYVFVI 9
           N+IY+F++
Sbjct: 591 NAIYLFLV 598
>XP_006713339
          Length = 1616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   NSIYVFVI 9
           N+IY+F++
Sbjct: 592 NAIYLFLV 599
>NP_004937
          Length = 1830

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SNSIYVFV 8
           ++S+YVFV
Sbjct: 220 THSLYVFV 227
>NP_039225
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  SIYVFVI 9
          ++YVF+I
Sbjct: 35 AVYVFII 41
>NP_115604
          Length = 515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  NSIYVFV 8
          NS+YV V
Sbjct: 38 NSVYVLV 44
>XP_005275582
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  SIYVFVI 9
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005275581
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  SIYVFVI 9
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005275423
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  SIYVFVI 9
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005275422
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  SIYVFVI 9
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005275288
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  SIYVFVI 9
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005275287
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  SIYVFVI 9
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005275147
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  SIYVFVI 9
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005275146
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  SIYVFVI 9
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005274992
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  SIYVFVI 9
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005274991
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  SIYVFVI 9
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005272846
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  SIYVFVI 9
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005272845
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  SIYVFVI 9
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005274901
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  SIYVFVI 9
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005274900
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  SIYVFVI 9
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005249059
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  SIYVFVI 9
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005249058
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  SIYVFVI 9
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_001717126
          Length = 1029

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SNSIYVFV 8
           SNS Y++V
Sbjct: 524 SNSTYLYV 531
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.145    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 383,381
Number of extensions: 662
Number of successful extensions: 44
Number of sequences better than 10000.0: 44
Number of HSP's gapped: 44
Number of HSP's successfully gapped: 44
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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