Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           19     869
NP_004561                                                              19     869
NP_001275703                                                           19     869
XP_005253450                                                           19     869
XP_006719151                                                           19     869
NP_064502                                                              17    2528
NP_964014                                                              17    3301
NP_733936                                                              16    5631
NP_001071                                                              16    5631
NP_950245                                                              16    5631
NP_001243057                                                           16    5631
NP_001243056                                                           16    5631
NP_001121683                                                           16    5631
NP_116258                                                              16    5631
XP_006716736                                                           16    5631
NP_061028                                                              16    7355
NP_775105                                                              16    7355
NP_037423                                                              16    7355
NP_001036148                                                           16    7355
NP_542172                                                              16    7355
XP_006716612                                                           16    7355
XP_006716611                                                           16    7355
XP_006715506                                                           16    7355
XP_006715505                                                           16    7355
XP_006715504                                                           16    7355
XP_006715503                                                           16    7355
XP_006715502                                                           16    7355
NP_001106849                                                           15    9605
NP_060663                                                              15    9605
NP_848519                                                              15    9605
NP_001164111                                                           15    9605
NP_036251                                                              15    9605
NP_001164110                                                           15    9605
NP_001034892                                                           15    9605
NP_001074025                                                           15    9605
XP_005256532                                                           15    9605
XP_005251917                                                           15    9605
XP_005270863                                                           15    9605
XP_005270862                                                           15    9605
XP_006710667                                                           15    9605
XP_006710666                                                           15    9605
NP_001139108                                                           15    9605
NP_659491                                                              15    9605
>NP_001275701
          Length = 1486

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SNQYLIQVT 9
            SN YLIQVT
Sbjct: 1259 SNLYLIQVT 1267
>NP_004561
          Length = 1445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SNQYLIQVT 9
            SN YLIQVT
Sbjct: 1218 SNLYLIQVT 1226
>NP_001275703
          Length = 1264

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SNQYLIQVT 9
            SN YLIQVT
Sbjct: 1037 SNLYLIQVT 1045
>XP_005253450
          Length = 1486

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SNQYLIQVT 9
            SN YLIQVT
Sbjct: 1259 SNLYLIQVT 1267
>XP_006719151
          Length = 1486

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SNQYLIQVT 9
            SN YLIQVT
Sbjct: 1259 SNLYLIQVT 1267
>NP_064502
          Length = 1176

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SNQYLIQVT 9
           S+QYL++VT
Sbjct: 898 SSQYLMEVT 906
>NP_964014
          Length = 175

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NQYLIQVT 9
           NQYL Q+T
Sbjct: 165 NQYLPQIT 172
>NP_733936
          Length = 548

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SNQYLIQ 7
           SNQ+L+Q
Sbjct: 356 SNQFLVQ 362
>NP_001071
          Length = 535

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SNQYLIQ 7
           SNQ+L+Q
Sbjct: 343 SNQFLVQ 349
>NP_950245
          Length = 384

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNQYLIQV 8
           +NQY IQV
Sbjct: 329 ANQYSIQV 336
>NP_001243057
          Length = 335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNQYLIQV 8
           +NQY IQV
Sbjct: 280 ANQYSIQV 287
>NP_001243056
          Length = 335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNQYLIQV 8
           +NQY IQV
Sbjct: 280 ANQYSIQV 287
>NP_001121683
          Length = 554

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SNQYLIQV 8
           SNQYL  V
Sbjct: 409 SNQYLFSV 416
>NP_116258
          Length = 583

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SNQYLIQV 8
           SNQYL  V
Sbjct: 438 SNQYLFSV 445
>XP_006716736
          Length = 496

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SNQYLIQV 8
           SNQYL  V
Sbjct: 351 SNQYLFSV 358
>NP_061028
          Length = 632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   NQYLIQV 8
           N YL+QV
Sbjct: 266 NSYLVQV 272
>NP_775105
          Length = 1659

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNQYLIQV 8
           SNQ+LI V
Sbjct: 146 SNQFLIYV 153
>NP_037423
          Length = 1443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   NQYLIQVT 9
           N+Y++QV+
Sbjct: 615 NRYIVQVS 622
>NP_001036148
          Length = 1683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNQYLIQV 8
           SNQ+LI V
Sbjct: 146 SNQFLIYV 153
>NP_542172
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SNQYLI 6
           SNQYL+
Sbjct: 272 SNQYLV 277
>XP_006716612
          Length = 1365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   NQYLIQVT 9
           N+Y++QV+
Sbjct: 537 NRYIVQVS 544
>XP_006716611
          Length = 1440

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   NQYLIQVT 9
           N+Y++QV+
Sbjct: 615 NRYIVQVS 622
>XP_006715506
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNQYLIQV 8
           SNQ+LI V
Sbjct: 146 SNQFLIYV 153
>XP_006715505
          Length = 1673

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNQYLIQV 8
           SNQ+LI V
Sbjct: 146 SNQFLIYV 153
>XP_006715504
          Length = 1683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNQYLIQV 8
           SNQ+LI V
Sbjct: 146 SNQFLIYV 153
>XP_006715503
          Length = 1707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNQYLIQV 8
           SNQ+LI V
Sbjct: 146 SNQFLIYV 153
>XP_006715502
          Length = 1707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNQYLIQV 8
           SNQ+LI V
Sbjct: 146 SNQFLIYV 153
>NP_001106849
          Length = 1328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QYLIQVT 9
           QY+IQ+T
Sbjct: 172 QYVIQLT 178
>NP_060663
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QYLIQVT 9
           QY+IQ+T
Sbjct: 172 QYVIQLT 178
>NP_848519
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  NQYLIQV 8
          NQY++Q+
Sbjct: 74 NQYVVQL 80
>NP_001164111
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  NQYLIQV 8
          NQY++Q+
Sbjct: 61 NQYVVQL 67
>NP_036251
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  NQYLIQV 8
          NQY++Q+
Sbjct: 61 NQYVVQL 67
>NP_001164110
          Length = 275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  NQYLIQV 8
          NQY++Q+
Sbjct: 61 NQYVVQL 67
>NP_001034892
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  NQYLIQV 8
          NQY++Q+
Sbjct: 61 NQYVVQL 67
>NP_001074025
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   NQYLIQVT 9
           NQY++ V+
Sbjct: 531 NQYIVSVS 538
>XP_005256532
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   NQYLIQVT 9
           NQY++ V+
Sbjct: 510 NQYIVSVS 517
>XP_005251917
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  NQYLIQV 8
          NQY++Q+
Sbjct: 61 NQYVVQL 67
>XP_005270863
          Length = 391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  SNQYLIQ 7
          SN+YLI+
Sbjct: 92 SNRYLIE 98
>XP_005270862
          Length = 431

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  SNQYLIQ 7
          SN+YLI+
Sbjct: 92 SNRYLIE 98
>XP_006710667
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  SNQYLIQ 7
          SN+YLI+
Sbjct: 92 SNRYLIE 98
>XP_006710666
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  SNQYLIQ 7
          SN+YLI+
Sbjct: 92 SNRYLIE 98
>NP_001139108
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  SNQYLIQ 7
          SN+YLI+
Sbjct: 92 SNRYLIE 98
>NP_659491
          Length = 620

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   NQYLIQVT 9
           NQY++ V+
Sbjct: 599 NQYIVSVS 606
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.125    0.316 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 435,102
Number of extensions: 663
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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