Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              20     390
NP_115548                                                              18    1482
XP_005249940                                                           18    1482
XP_005249939                                                           18    1482
XP_006715854                                                           18    1482
XP_006715853                                                           18    1482
NP_001127880                                                           17    3301
NP_000824                                                              17    3301
NP_001127879                                                           17    3301
NP_653250                                                              17    3301
XP_005255325                                                           17    3301
XP_005255324                                                           17    3301
XP_006716571                                                           17    3301
XP_006716570                                                           17    3301
XP_005250852                                                           17    3301
XP_005250851                                                           17    3301
NP_000171                                                              17    4312
NP_001034553                                                           17    4312
NP_073585                                                              17    4312
XP_005248008                                                           17    4312
XP_006713927                                                           17    4312
NP_660334                                                              17    4312
NP_002522                                                              17    4312
NP_006226                                                              16    5631
XP_006718977                                                           16    5631
XP_006718922                                                           16    5631
XP_005271651                                                           16    5631
XP_005271650                                                           16    5631
NP_000236                                                              16    7355
NP_001120972                                                           16    7355
NP_002323                                                              16    7355
NP_001229658                                                           16    7355
NP_001186308                                                           16    7355
NP_060736                                                              16    7355
NP_001186307                                                           16    7355
NP_006447                                                              16    7355
NP_001072                                                              16    7355
NP_004184                                                              16    7355
XP_005257011                                                           16    7355
XP_006718114                                                           16    7355
XP_005270318                                                           16    7355
XP_006718113                                                           16    7355
XP_006718112                                                           16    7355
XP_006718111                                                           16    7355
XP_006718110                                                           16    7355
XP_006716052                                                           16    7355
XP_006716051                                                           16    7355
XP_006714307                                                           16    7355
XP_006713750                                                           16    7355
NP_001005367                                                           15    9605
NP_001188390                                                           15    9605
NP_065710                                                              15    9605
NP_056169                                                              15    9605
NP_002888                                                              15    9605
NP_058520                                                              15    9605
XP_006726337                                                           15    9605
XP_006723359                                                           15    9605
XP_006712738                                                           15    9605
XP_006712737                                                           15    9605
XP_006712736                                                           15    9605
XP_005246797                                                           15    9605
XP_005246798                                                           15    9605
XP_005246796                                                           15    9605
XP_006712735                                                           15    9605
XP_005246795                                                           15    9605
XP_005246794                                                           15    9605
XP_006712734                                                           15    9605
>NP_443179
          Length = 2170

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SNHTLSLQS 9
           SNH+LSLQS
Sbjct: 168 SNHSLSLQS 176
>NP_115548
          Length = 1316

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  SNHTLSL 7
          SNHTLSL
Sbjct: 48 SNHTLSL 54
>XP_005249940
          Length = 737

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  SNHTLSL 7
          SNHTLSL
Sbjct: 48 SNHTLSL 54
>XP_005249939
          Length = 1324

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  SNHTLSL 7
          SNHTLSL
Sbjct: 48 SNHTLSL 54
>XP_006715854
          Length = 1327

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  SNHTLSL 7
          SNHTLSL
Sbjct: 48 SNHTLSL 54
>XP_006715853
          Length = 1327

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  SNHTLSL 7
          SNHTLSL
Sbjct: 48 SNHTLSL 54
>NP_001127880
          Length = 1281

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   NHTLSLQ 8
           NHTLSL+
Sbjct: 380 NHTLSLR 386
>NP_000824
          Length = 1464

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   NHTLSLQ 8
           NHTLSL+
Sbjct: 380 NHTLSLR 386
>NP_001127879
          Length = 1464

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   NHTLSLQ 8
           NHTLSL+
Sbjct: 380 NHTLSLR 386
>NP_653250
          Length = 276

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SNHTLSLQS 9
           ++H+LSLQS
Sbjct: 182 NSHSLSLQS 190
>XP_005255325
          Length = 1333

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   NHTLSLQ 8
           NHTLSL+
Sbjct: 432 NHTLSLR 438
>XP_005255324
          Length = 1516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   NHTLSLQ 8
           NHTLSL+
Sbjct: 432 NHTLSLR 438
>XP_006716571
          Length = 116

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  SNHTLSLQS 9
          ++H+LSLQS
Sbjct: 22 NSHSLSLQS 30
>XP_006716570
          Length = 290

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SNHTLSLQS 9
           ++H+LSLQS
Sbjct: 196 NSHSLSLQS 204
>XP_005250852
          Length = 294

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SNHTLSLQS 9
           ++H+LSLQS
Sbjct: 200 NSHSLSLQS 208
>XP_005250851
          Length = 295

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SNHTLSLQS 9
           ++H+LSLQS
Sbjct: 201 NSHSLSLQS 209
>NP_000171
          Length = 1103

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SNHTLSLQ 8
            SNH +SLQ
Sbjct: 1077 SNHGISLQ 1084
>NP_001034553
          Length = 1323

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SNHTLSLQS 9
           SN TLSL S
Sbjct: 333 SNETLSLDS 341
>NP_073585
          Length = 1445

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNHTLSLQS 9
           S+HTLS+ S
Sbjct: 383 SDHTLSVSS 391
>XP_005248008
          Length = 466

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   NHTLSLQS 9
           N TLSLQS
Sbjct: 131 NSTLSLQS 138
>XP_006713927
          Length = 765

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   NHTLSLQS 9
           N TLSLQS
Sbjct: 131 NSTLSLQS 138
>NP_660334
          Length = 765

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   NHTLSLQS 9
           N TLSLQS
Sbjct: 131 NSTLSLQS 138
>NP_002522
          Length = 418

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SNHTLS 6
           SNHTLS
Sbjct: 404 SNHTLS 409
>NP_006226
          Length = 256

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NHTLSLQ 8
           NHTLS++
Sbjct: 248 NHTLSVE 254
>XP_006718977
          Length = 293

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  NHTLSLQS 9
          NH+LSL++
Sbjct: 9  NHSLSLEA 16
>XP_006718922
          Length = 276

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NHTLSLQ 8
           NHTLS++
Sbjct: 268 NHTLSVE 274
>XP_005271651
          Length = 303

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NHTLSLQ 8
           NHTLS++
Sbjct: 295 NHTLSVE 301
>XP_005271650
          Length = 303

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NHTLSLQ 8
           NHTLS++
Sbjct: 295 NHTLSVE 301
>NP_000236
          Length = 1390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   NHTLSLQS 9
           NHT  +QS
Sbjct: 149 NHTADIQS 156
>NP_001120972
          Length = 1408

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   NHTLSLQS 9
           NHT  +QS
Sbjct: 149 NHTADIQS 156
>NP_002323
          Length = 4544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    NHTLSLQS 9
            NHT  +QS
Sbjct: 1218 NHTCQIQS 1225
>NP_001229658
          Length = 777

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNHTLSLQ 8
           S+H LSLQ
Sbjct: 728 SDHELSLQ 735
>NP_001186308
          Length = 1855

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SNHTLSLQ 8
            S HT+SLQ
Sbjct: 1486 SYHTVSLQ 1493
>NP_060736
          Length = 488

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   NHTLSL 7
           NHTLS+
Sbjct: 446 NHTLSM 451
>NP_001186307
          Length = 1856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SNHTLSLQ 8
            S HT+SLQ
Sbjct: 1487 SYHTVSLQ 1494
>NP_006447
          Length = 374

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SNHTLSLQS 9
           +NH LSL++
Sbjct: 349 ANHDLSLEA 357
>NP_001072
          Length = 3623

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    NHTLSL 7
            NHT+SL
Sbjct: 3430 NHTISL 3435
>NP_004184
          Length = 1859

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SNHTLSLQ 8
            S HT+SLQ
Sbjct: 1486 SYHTVSLQ 1493
>XP_005257011
          Length = 346

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SNHTLSLQS 9
           +NH LSL++
Sbjct: 321 ANHDLSLEA 329
>XP_006718114
          Length = 1850

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SNHTLSLQ 8
            S HT+SLQ
Sbjct: 1520 SYHTVSLQ 1527
>XP_005270318
          Length = 1860

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SNHTLSLQ 8
            S HT+SLQ
Sbjct: 1487 SYHTVSLQ 1494
>XP_006718113
          Length = 1881

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SNHTLSLQ 8
            S HT+SLQ
Sbjct: 1508 SYHTVSLQ 1515
>XP_006718112
          Length = 1889

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SNHTLSLQ 8
            S HT+SLQ
Sbjct: 1520 SYHTVSLQ 1527
>XP_006718111
          Length = 1892

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SNHTLSLQ 8
            S HT+SLQ
Sbjct: 1519 SYHTVSLQ 1526
>XP_006718110
          Length = 1893

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SNHTLSLQ 8
            S HT+SLQ
Sbjct: 1520 SYHTVSLQ 1527
>XP_006716052
          Length = 1409

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   NHTLSLQS 9
           NHT  +QS
Sbjct: 168 NHTADIQS 175
>XP_006716051
          Length = 1427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   NHTLSLQS 9
           NHT  +QS
Sbjct: 168 NHTADIQS 175
>XP_006714307
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNHTLSLQ 8
           S+H LSLQ
Sbjct: 510 SDHELSLQ 517
>XP_006713750
          Length = 488

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   NHTLSL 7
           NHTLS+
Sbjct: 446 NHTLSM 451
>NP_001005367
          Length = 460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SNHTLS 6
           +NHTLS
Sbjct: 129 ANHTLS 134
>NP_001188390
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SNHTLS 6
           +NHTLS
Sbjct: 129 ANHTLS 134
>NP_065710
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SNHTLS 6
           +NHTLS
Sbjct: 129 ANHTLS 134
>NP_056169
          Length = 1749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNHTLSLQ 8
           S+HT SLQ
Sbjct: 754 SSHTPSLQ 761
>NP_002888
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HTLSLQ 8
           HT+SLQ
Sbjct: 324 HTMSLQ 329
>NP_058520
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HTLSLQ 8
           HT+SLQ
Sbjct: 327 HTMSLQ 332
>XP_006726337
          Length = 400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SNHTLS 6
           +NHTLS
Sbjct: 129 ANHTLS 134
>XP_006723359
          Length = 400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SNHTLS 6
           +NHTLS
Sbjct: 129 ANHTLS 134
>XP_006712738
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HTLSLQ 8
           HT+SLQ
Sbjct: 324 HTMSLQ 329
>XP_006712737
          Length = 405

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HTLSLQ 8
           HT+SLQ
Sbjct: 326 HTMSLQ 331
>XP_006712736
          Length = 408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HTLSLQ 8
           HT+SLQ
Sbjct: 329 HTMSLQ 334
>XP_005246797
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HTLSLQ 8
           HT+SLQ
Sbjct: 340 HTMSLQ 345
>XP_005246798
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HTLSLQ 8
           HT+SLQ
Sbjct: 340 HTMSLQ 345
>XP_005246796
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HTLSLQ 8
           HT+SLQ
Sbjct: 341 HTMSLQ 346
>XP_006712735
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HTLSLQ 8
           HT+SLQ
Sbjct: 342 HTMSLQ 347
>XP_005246795
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HTLSLQ 8
           HT+SLQ
Sbjct: 342 HTMSLQ 347
>XP_005246794
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HTLSLQ 8
           HT+SLQ
Sbjct: 343 HTMSLQ 348
>XP_006712734
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HTLSLQ 8
           HT+SLQ
Sbjct: 345 HTMSLQ 350
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.296    0.104    0.256 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 488,352
Number of extensions: 595
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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