Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              19     665
XP_006713721                                                           19     665
XP_006712077                                                           17    4312
XP_006712076                                                           17    4312
XP_006712075                                                           17    4312
XP_006712074                                                           17    4312
XP_006712073                                                           17    4312
XP_006712072                                                           17    4312
XP_006712071                                                           17    4312
NP_079334                                                              16    5631
NP_001243529                                                           16    5631
NP_001269307                                                           16    5631
NP_001243528                                                           16    5631
NP_001243530                                                           16    5631
NP_001070884                                                           16    7355
NP_001073896                                                           15    9605
NP_001075956                                                           15    9605
NP_000102                                                              15    9605
NP_075065                                                              15    9605
XP_005256172                                                           15    9605
XP_006715936                                                           15    9605
XP_005263859                                                           15    9605
NP_001075955                                                           15    9605
NP_057558                                                              15    9605
>NP_006209
          Length = 1068

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SNAGLSNRL 9
           S+AGLSNRL
Sbjct: 509 SHAGLSNRL 517
>XP_006713721
          Length = 1068

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SNAGLSNRL 9
           S+AGLSNRL
Sbjct: 509 SHAGLSNRL 517
>XP_006712077
          Length = 241

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNAGLSNRL 9
           SN+G+S RL
Sbjct: 228 SNSGVSGRL 236
>XP_006712076
          Length = 280

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNAGLSNRL 9
           SN+G+S RL
Sbjct: 267 SNSGVSGRL 275
>XP_006712075
          Length = 325

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNAGLSNRL 9
           SN+G+S RL
Sbjct: 312 SNSGVSGRL 320
>XP_006712074
          Length = 325

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNAGLSNRL 9
           SN+G+S RL
Sbjct: 312 SNSGVSGRL 320
>XP_006712073
          Length = 326

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNAGLSNRL 9
           SN+G+S RL
Sbjct: 313 SNSGVSGRL 321
>XP_006712072
          Length = 370

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNAGLSNRL 9
           SN+G+S RL
Sbjct: 357 SNSGVSGRL 365
>XP_006712071
          Length = 371

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SNAGLSNRL 9
           SN+G+S RL
Sbjct: 358 SNSGVSGRL 366
>NP_079334
          Length = 759

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNAGLSNR 8
           SNAGL+ R
Sbjct: 669 SNAGLTGR 676
>NP_001243529
          Length = 717

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNAGLSNR 8
           SNAGL+ R
Sbjct: 627 SNAGLTGR 634
>NP_001269307
          Length = 633

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNAGLSNR 8
           SNAGL+ R
Sbjct: 543 SNAGLTGR 550
>NP_001243528
          Length = 736

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNAGLSNR 8
           SNAGL+ R
Sbjct: 646 SNAGLTGR 653
>NP_001243530
          Length = 746

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SNAGLSNR 8
           SNAGL+ R
Sbjct: 656 SNAGLTGR 663
>NP_001070884
          Length = 369

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SNAGLSNRL 9
          + AGL NRL
Sbjct: 84 ARAGLPNRL 92
>NP_001073896
          Length = 1577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  SNAGLSNR 8
          SN G SNR
Sbjct: 48 SNCGESNR 55
>NP_001075956
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SNAGLS 6
           SNAGLS
Sbjct: 245 SNAGLS 250
>NP_000102
          Length = 764

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SNAGLSNRL 9
           +N GL NR+
Sbjct: 747 TNGGLRNRV 755
>NP_075065
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SNAGLS 6
           SNAGLS
Sbjct: 245 SNAGLS 250
>XP_005256172
          Length = 515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SNAGLS 6
           SNAGLS
Sbjct: 248 SNAGLS 253
>XP_006715936
          Length = 764

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SNAGLSNRL 9
           +N GL NR+
Sbjct: 747 TNGGLRNRV 755
>XP_005263859
          Length = 1606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  SNAGLSNR 8
          SN G SNR
Sbjct: 79 SNCGESNR 86
>NP_001075955
          Length = 544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SNAGLS 6
           SNAGLS
Sbjct: 248 SNAGLS 253
>NP_057558
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  NAGLSNR 8
          N G+SNR
Sbjct: 58 NVGVSNR 64
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.303    0.120    0.304 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 449,707
Number of extensions: 483
Number of successful extensions: 24
Number of sequences better than 10000.0: 24
Number of HSP's gapped: 24
Number of HSP's successfully gapped: 24
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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