Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     509
XP_005262424                                                           20     509
NP_878908                                                              17    4312
XP_006726924                                                           17    4312
XP_005258838                                                           17    4312
NP_775904                                                              17    4312
NP_055994                                                              16    5631
NP_001138586                                                           16    5631
NP_001271266                                                           16    5631
NP_002227                                                              16    7355
NP_640334                                                              15    9605
NP_006454                                                              15    9605
NP_998787                                                              15    9605
NP_964010                                                              15    9605
NP_001259017                                                           15    9605
NP_001259016                                                           15    9605
NP_001271160                                                           15    9605
NP_001271161                                                           15    9605
NP_775829                                                              15    9605
NP_001271159                                                           15    9605
NP_149132                                                              15    9605
NP_005062                                                              15    9605
XP_006722907                                                           15    9605
XP_006722906                                                           15    9605
XP_006722905                                                           15    9605
XP_006720213                                                           15    9605
XP_006720212                                                           15    9605
XP_005267740                                                           15    9605
XP_006719093                                                           15    9605
XP_005253367                                                           15    9605
XP_005253366                                                           15    9605
XP_005253365                                                           15    9605
XP_005253364                                                           15    9605
XP_005253363                                                           15    9605
XP_005253362                                                           15    9605
XP_005253361                                                           15    9605
XP_005248970                                                           15    9605
XP_005248969                                                           15    9605
XP_006715079                                                           15    9605
XP_005248968                                                           15    9605
XP_005264148                                                           15    9605
XP_005264145                                                           15    9605
XP_006711984                                                           15    9605
XP_006711983                                                           15    9605
>NP_722576
          Length = 3080

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SMTLTHVML 9
            SM LTHVML
Sbjct: 2507 SMNLTHVML 2515
>XP_005262424
          Length = 2875

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SMTLTHVML 9
            SM LTHVML
Sbjct: 2302 SMNLTHVML 2310
>NP_878908
          Length = 465

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SMTLTHVML 9
           ++T THVML
Sbjct: 195 AVTKTHVML 203
>XP_006726924
          Length = 451

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SMTLTHVML 9
           ++T THVML
Sbjct: 181 AVTKTHVML 189
>XP_005258838
          Length = 563

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TLTHVML 9
           TLTHV+L
Sbjct: 302 TLTHVVL 308
>NP_775904
          Length = 493

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TLTHVML 9
           TLTHV+L
Sbjct: 288 TLTHVVL 294
>NP_055994
          Length = 1297

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MTLTHVML 9
           MTL+HV++
Sbjct: 334 MTLSHVLV 341
>NP_001138586
          Length = 1236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MTLTHVML 9
           MTL+HV++
Sbjct: 273 MTLSHVLV 280
>NP_001271266
          Length = 1197

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MTLTHVML 9
           MTL+HV++
Sbjct: 234 MTLSHVLV 241
>NP_002227
          Length = 494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SMTLTHV 7
           S+TLTH+
Sbjct: 269 SLTLTHL 275
>NP_640334
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SMTLTHVML 9
           S+TL H ML
Sbjct: 338 SLTLQHHML 346
>NP_006454
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   TLTHVML 9
           T+THV++
Sbjct: 295 TITHVLI 301
>NP_998787
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   TLTHVML 9
           T+THV++
Sbjct: 295 TITHVLI 301
>NP_964010
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   TLTHVML 9
           T+THV++
Sbjct: 295 TITHVLI 301
>NP_001259017
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  SMTLTHVM 8
          +MTL HV+
Sbjct: 43 TMTLEHVL 50
>NP_001259016
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  SMTLTHVM 8
          +MTL HV+
Sbjct: 43 TMTLEHVL 50
>NP_001271160
          Length = 880

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SMTLTHVML 9
           S+T THV L
Sbjct: 671 SLTPTHVTL 679
>NP_001271161
          Length = 837

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SMTLTHVML 9
           S+T THV L
Sbjct: 628 SLTPTHVTL 636
>NP_775829
          Length = 655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SMTLTHVML 9
           S+TL H ML
Sbjct: 235 SLTLQHHML 243
>NP_001271159
          Length = 1104

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SMTLTHVML 9
           S+T THV L
Sbjct: 895 SLTPTHVTL 903
>NP_149132
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SMTLTHVML 9
           S+T THV L
Sbjct: 909 SLTPTHVTL 917
>NP_005062
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  SMTLTHVM 8
          +MTL HV+
Sbjct: 43 TMTLEHVL 50
>XP_006722907
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  SMTLTHVM 8
          +MTL HV+
Sbjct: 43 TMTLEHVL 50
>XP_006722906
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  SMTLTHVM 8
          +MTL HV+
Sbjct: 43 TMTLEHVL 50
>XP_006722905
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  SMTLTHVM 8
          +MTL HV+
Sbjct: 43 TMTLEHVL 50
>XP_006720213
          Length = 933

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SMTLTHVML 9
           S+T THV L
Sbjct: 724 SLTPTHVTL 732
>XP_006720212
          Length = 956

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SMTLTHVML 9
           S+T THV L
Sbjct: 747 SLTPTHVTL 755
>XP_005267740
          Length = 1081

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SMTLTHVML 9
           S+T THV L
Sbjct: 872 SLTPTHVTL 880
>XP_006719093
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SMTLTHVML 9
          S+TL H ML
Sbjct: 90 SLTLQHHML 98
>XP_005253367
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SMTLTHVML 9
          S+TL H ML
Sbjct: 90 SLTLQHHML 98
>XP_005253366
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SMTLTHVML 9
           S+TL H ML
Sbjct: 245 SLTLQHHML 253
>XP_005253365
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SMTLTHVML 9
           S+TL H ML
Sbjct: 245 SLTLQHHML 253
>XP_005253364
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SMTLTHVML 9
           S+TL H ML
Sbjct: 245 SLTLQHHML 253
>XP_005253363
          Length = 851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SMTLTHVML 9
           S+TL H ML
Sbjct: 423 SLTLQHHML 431
>XP_005253362
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SMTLTHVML 9
           S+TL H ML
Sbjct: 450 SLTLQHHML 458
>XP_005253361
          Length = 930

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SMTLTHVML 9
           S+TL H ML
Sbjct: 502 SLTLQHHML 510
>XP_005248970
          Length = 455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SMTLTHVML 9
          S+TL H ML
Sbjct: 35 SLTLQHHML 43
>XP_005248969
          Length = 455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SMTLTHVML 9
          S+TL H ML
Sbjct: 35 SLTLQHHML 43
>XP_006715079
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SMTLTHVML 9
          S+TL H ML
Sbjct: 68 SLTLQHHML 76
>XP_005248968
          Length = 620

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SMTLTHVML 9
           S+TL H ML
Sbjct: 235 SLTLQHHML 243
>XP_005264148
          Length = 289

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   TLTHVML 9
           T+THV++
Sbjct: 160 TITHVLI 166
>XP_005264145
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   TLTHVML 9
           T+THV++
Sbjct: 295 TITHVLI 301
>XP_006711984
          Length = 457

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   TLTHVML 9
           T+THV++
Sbjct: 342 TITHVLI 348
>XP_006711983
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   TLTHVML 9
           T+THV++
Sbjct: 342 TITHVLI 348
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.126    0.339 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 490,178
Number of extensions: 475
Number of successful extensions: 44
Number of sequences better than 10000.0: 44
Number of HSP's gapped: 44
Number of HSP's successfully gapped: 44
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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