Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              19     665
XP_005262424                                                           19     665
NP_001094811                                                           18    1482
NP_001005278                                                           17    2528
NP_789743                                                              17    3301
NP_001092806                                                           17    3301
NP_940923                                                              17    3301
XP_006719444                                                           17    3301
NP_005192                                                              17    3301
NP_631958                                                              17    4312
NP_631957                                                              17    4312
NP_115884                                                              17    4312
NP_001138932                                                           17    4312
NP_001138931                                                           17    4312
XP_006714116                                                           17    4312
XP_006714115                                                           17    4312
XP_005265840                                                           17    4312
XP_006714114                                                           17    4312
NP_653309                                                              16    5631
NP_002829                                                              16    5631
NP_563578                                                              16    5631
NP_940959                                                              16    5631
XP_006726577                                                           16    5631
XP_006711538                                                           16    5631
XP_006711537                                                           16    5631
XP_006711536                                                           16    5631
XP_006711535                                                           16    5631
XP_006709997                                                           16    5631
NP_001003690                                                           16    7355
NP_055443                                                              16    7355
NP_054730                                                              16    7355
XP_006720777                                                           16    7355
NP_659198                                                              16    7355
NP_000769                                                              15    9605
NP_775754                                                              15    9605
NP_009147                                                              15    9605
NP_852608                                                              15    9605
NP_852609                                                              15    9605
NP_055873                                                              15    9605
NP_001009814                                                           15    9605
NP_004807                                                              15    9605
NP_001121080                                                           15    9605
NP_055737                                                              15    9605
NP_001028225                                                           15    9605
NP_127497                                                              15    9605
NP_127500                                                              15    9605
NP_127499                                                              15    9605
NP_758519                                                              15    9605
NP_000751                                                              15    9605
NP_724781                                                              15    9605
NP_835235                                                              15    9605
NP_828847                                                              15    9605
NP_001010969                                                           15    9605
NP_001005469                                                           15    9605
XP_006719855                                                           15    9605
XP_006719853                                                           15    9605
XP_005252821                                                           15    9605
XP_005252820                                                           15    9605
XP_005252819                                                           15    9605
XP_005252818                                                           15    9605
XP_005252366                                                           15    9605
XP_005252365                                                           15    9605
XP_005252364                                                           15    9605
XP_005270825                                                           15    9605
XP_005270824                                                           15    9605
XP_005270596                                                           15    9605
XP_005270594                                                           15    9605
XP_006710455                                                           15    9605
XP_005270552                                                           15    9605
XP_005270550                                                           15    9605
XP_005270549                                                           15    9605
NP_001005284                                                           15    9605
NP_001265437                                                           15    9605
NP_037388                                                              15    9605
NP_001275688                                                           15    9605
>NP_722576
          Length = 3080

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SMSTTLCLK 9
           SMSTT CLK
Sbjct: 411 SMSTTPCLK 419
>XP_005262424
          Length = 2875

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SMSTTLCLK 9
           SMSTT CLK
Sbjct: 206 SMSTTPCLK 214
>NP_001094811
          Length = 94

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  SMSTTLCLK 9
          S STTLCL+
Sbjct: 39 SESTTLCLR 47
>NP_001005278
          Length = 317

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MSTTLCLK 9
           M+TTLC K
Sbjct: 136 MTTTLCAK 143
>NP_789743
          Length = 342

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SMSTTLCL 8
           S+STT CL
Sbjct: 165 SLSTTACL 172
>NP_001092806
          Length = 360

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2 MSTTLCLK 9
         MST +C+K
Sbjct: 1 MSTVICMK 8
>NP_940923
          Length = 360

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2 MSTTLCLK 9
         MST +C+K
Sbjct: 1 MSTVICMK 8
>XP_006719444
          Length = 236

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2 MSTTLCLK 9
         MST +C+K
Sbjct: 1 MSTVICMK 8
>NP_005192
          Length = 355

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   MSTTLCL 8
           M TTLCL
Sbjct: 149 MGTTLCL 155
>NP_631958
          Length = 73

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  STTLCL 8
          STTLCL
Sbjct: 30 STTLCL 35
>NP_631957
          Length = 73

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  STTLCL 8
          STTLCL
Sbjct: 30 STTLCL 35
>NP_115884
          Length = 91

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  STTLCL 8
          STTLCL
Sbjct: 48 STTLCL 53
>NP_001138932
          Length = 112

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  STTLCL 8
          STTLCL
Sbjct: 48 STTLCL 53
>NP_001138931
          Length = 73

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  STTLCL 8
          STTLCL
Sbjct: 30 STTLCL 35
>XP_006714116
          Length = 108

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  STTLCL 8
          STTLCL
Sbjct: 45 STTLCL 50
>XP_006714115
          Length = 111

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  STTLCL 8
          STTLCL
Sbjct: 48 STTLCL 53
>XP_005265840
          Length = 111

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  STTLCL 8
          STTLCL
Sbjct: 68 STTLCL 73
>XP_006714114
          Length = 131

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  STTLCL 8
          STTLCL
Sbjct: 68 STTLCL 73
>NP_653309
          Length = 1434

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SMSTTLCL 8
           S+ TT+CL
Sbjct: 582 SLETTVCL 589
>NP_002829
          Length = 1306

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TT+CLK
Sbjct: 319 TTICLK 324
>NP_563578
          Length = 1145

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TT+CLK
Sbjct: 158 TTICLK 163
>NP_940959
          Length = 357

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TT+CLK
Sbjct: 257 TTICLK 262
>XP_006726577
          Length = 201

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SMSTTLCL 8
           +++TTLCL
Sbjct: 182 AVTTTLCL 189
>XP_006711538
          Length = 1189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TT+CLK
Sbjct: 202 TTICLK 207
>XP_006711537
          Length = 1192

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TT+CLK
Sbjct: 205 TTICLK 210
>XP_006711536
          Length = 1240

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TT+CLK
Sbjct: 253 TTICLK 258
>XP_006711535
          Length = 1258

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TT+CLK
Sbjct: 271 TTICLK 276
>XP_006709997
          Length = 201

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SMSTTLCL 8
           +++TTLCL
Sbjct: 182 AVTTTLCL 189
>NP_001003690
          Length = 306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SMSTTLCLK 9
           S+ST  CL+
Sbjct: 212 SLSTAACLR 220
>NP_055443
          Length = 274

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SMSTTLCLK 9
           S+ST  CL+
Sbjct: 180 SLSTAACLR 188
>NP_054730
          Length = 536

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   STTLCLK 9
           +TTLCL+
Sbjct: 328 TTTLCLQ 334
>XP_006720777
          Length = 292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2 MSTTLC 7
         M+TTLC
Sbjct: 1 MNTTLC 6
>NP_659198
          Length = 536

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   STTLCLK 9
           +TTLCL+
Sbjct: 328 TTTLCLQ 334
>NP_000769
          Length = 519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TT+C+K
Sbjct: 372 TTMCIK 377
>NP_775754
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TT+C+K
Sbjct: 388 TTMCIK 393
>NP_009147
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TTLCL+
Sbjct: 627 TTLCLE 632
>NP_852608
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TTLCL+
Sbjct: 741 TTLCLE 746
>NP_852609
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TTLCL+
Sbjct: 627 TTLCLE 632
>NP_055873
          Length = 1905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SMSTTLC 7
           S +TTLC
Sbjct: 295 SFATTLC 301
>NP_001009814
          Length = 1039

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SMSTTLC 7
           S +TTLC
Sbjct: 295 SFATTLC 301
>NP_004807
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SMSTTLCL 8
           +++TT+CL
Sbjct: 95  ALTTTVCL 102
>NP_001121080
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SMSTTLCL 8
           +++TT+CL
Sbjct: 95  ALTTTVCL 102
>NP_055737
          Length = 1429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   STTLCL 8
           +TTLCL
Sbjct: 547 TTTLCL 552
>NP_001028225
          Length = 1375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   STTLCL 8
           +TTLCL
Sbjct: 547 TTTLCL 552
>NP_127497
          Length = 1473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   STTLCL 8
           +TTLCL
Sbjct: 547 TTTLCL 552
>NP_127500
          Length = 1399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   STTLCL 8
           +TTLCL
Sbjct: 547 TTTLCL 552
>NP_127499
          Length = 1443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   STTLCL 8
           +TTLCL
Sbjct: 547 TTTLCL 552
>NP_758519
          Length = 783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SMSTTLCL 8
           SMS  LCL
Sbjct: 212 SMSPQLCL 219
>NP_000751
          Length = 836

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SMSTTLCL 8
           SMS  LCL
Sbjct: 212 SMSPQLCL 219
>NP_724781
          Length = 863

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SMSTTLCL 8
           SMS  LCL
Sbjct: 212 SMSPQLCL 219
>NP_835235
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TT+C+K
Sbjct: 365 TTMCIK 370
>NP_828847
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TT+C+K
Sbjct: 367 TTMCIK 372
>NP_001010969
          Length = 519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TT+C+K
Sbjct: 372 TTMCIK 377
>NP_001005469
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   SMSTTLCLK 9
           +M+TT+C +
Sbjct: 133 TMTTTVCAR 141
>XP_006719855
          Length = 1046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SMSTTLC 7
           S +TTLC
Sbjct: 295 SFATTLC 301
>XP_006719853
          Length = 1809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SMSTTLC 7
           S +TTLC
Sbjct: 199 SFATTLC 205
>XP_005252821
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TTLCL+
Sbjct: 627 TTLCLE 632
>XP_005252820
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TTLCL+
Sbjct: 627 TTLCLE 632
>XP_005252819
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TTLCL+
Sbjct: 741 TTLCLE 746
>XP_005252818
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TTLCL+
Sbjct: 741 TTLCLE 746
>XP_005252366
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SMSTTLCL 8
           +++TT+CL
Sbjct: 95  ALTTTVCL 102
>XP_005252365
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SMSTTLCL 8
           +++TT+CL
Sbjct: 167 ALTTTVCL 174
>XP_005252364
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SMSTTLCL 8
           +++TT+CL
Sbjct: 248 ALTTTVCL 255
>XP_005270825
          Length = 357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TT+C+K
Sbjct: 274 TTMCIK 279
>XP_005270824
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TT+C+K
Sbjct: 274 TTMCIK 279
>XP_005270596
          Length = 357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TT+C+K
Sbjct: 274 TTMCIK 279
>XP_005270594
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TT+C+K
Sbjct: 268 TTMCIK 273
>XP_006710455
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   TTLCLK 9
           TT+C+K
Sbjct: 274 TTMCIK 279
>XP_005270552
          Length = 731

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  SMSTTLCL 8
          SMS  LCL
Sbjct: 80 SMSPQLCL 87
>XP_005270550
          Length = 835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SMSTTLCL 8
           SMS  LCL
Sbjct: 212 SMSPQLCL 219
>XP_005270549
          Length = 841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SMSTTLCL 8
           SMS  LCL
Sbjct: 190 SMSPQLCL 197
>NP_001005284
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SMSTTLC 7
           +MST LC
Sbjct: 150 TMSTALC 156
>NP_001265437
          Length = 667

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  MSTTLCLK 9
          +ST LCL+
Sbjct: 18 LSTLLCLE 25
>NP_037388
          Length = 692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  MSTTLCLK 9
          +ST LCL+
Sbjct: 18 LSTLLCLE 25
>NP_001275688
          Length = 691

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  MSTTLCLK 9
          +ST LCL+
Sbjct: 17 LSTLLCLE 24
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.117    0.333 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 564,225
Number of extensions: 536
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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