Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001167558                                                           21     229
NP_858045                                                              21     229
NP_006525                                                              21     229
NP_001167559                                                           21     229
NP_573439                                                              17    4312
NP_573438                                                              17    4312
NP_001181930                                                           17    4312
NP_005695                                                              17    4312
XP_006710336                                                           17    4312
XP_006710335                                                           17    4312
XP_006710334                                                           17    4312
XP_006710333                                                           17    4312
XP_006710332                                                           17    4312
NP_689548                                                              16    7355
NP_001268369                                                           16    7355
NP_068759                                                              16    7355
NP_001229852                                                           16    7355
NP_057175                                                              16    7355
NP_001037770                                                           16    7355
XP_005261682                                                           16    7355
XP_006724323                                                           16    7355
XP_005254217                                                           16    7355
NP_055950                                                              15    9605
NP_001138295                                                           15    9605
NP_005839                                                              15    9605
NP_055797                                                              15    9605
NP_060063                                                              15    9605
NP_942595                                                              15    9605
XP_005254179                                                           15    9605
XP_005254178                                                           15    9605
XP_006720435                                                           15    9605
XP_005254177                                                           15    9605
XP_006720434                                                           15    9605
XP_005254176                                                           15    9605
XP_005267486                                                           15    9605
XP_006720145                                                           15    9605
XP_005267485                                                           15    9605
XP_005267483                                                           15    9605
XP_005267482                                                           15    9605
XP_005267481                                                           15    9605
XP_005267480                                                           15    9605
XP_005267479                                                           15    9605
XP_005267478                                                           15    9605
XP_005267477                                                           15    9605
XP_005250292                                                           15    9605
XP_005263174                                                           15    9605
NP_001116437                                                           15    9605
>NP_001167558
          Length = 1423

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SMINQMNQQ 9
            SM+NQMNQQ
Sbjct: 1137 SMMNQMNQQ 1145
>NP_858045
          Length = 1424

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SMINQMNQQ 9
            SM+NQMNQQ
Sbjct: 1137 SMMNQMNQQ 1145
>NP_006525
          Length = 1420

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SMINQMNQQ 9
            SM+NQMNQQ
Sbjct: 1137 SMMNQMNQQ 1145
>NP_001167559
          Length = 1415

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SMINQMNQQ 9
            SM+NQMNQQ
Sbjct: 1132 SMMNQMNQQ 1140
>NP_573439
          Length = 1436

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MINQMNQ 8
            M+NQ+NQ
Sbjct: 1265 MLNQLNQ 1271
>NP_573438
          Length = 1440

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MINQMNQ 8
            M+NQ+NQ
Sbjct: 1271 MLNQLNQ 1277
>NP_001181930
          Length = 1433

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MINQMNQ 8
            M+NQ+NQ
Sbjct: 1262 MLNQLNQ 1268
>NP_005695
          Length = 1446

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MINQMNQ 8
            M+NQ+NQ
Sbjct: 1275 MLNQLNQ 1281
>XP_006710336
          Length = 1177

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MINQMNQ 8
            M+NQ+NQ
Sbjct: 1006 MLNQLNQ 1012
>XP_006710335
          Length = 1370

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MINQMNQ 8
            M+NQ+NQ
Sbjct: 1199 MLNQLNQ 1205
>XP_006710334
          Length = 1292

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MINQMNQ 8
            M+NQ+NQ
Sbjct: 1121 MLNQLNQ 1127
>XP_006710333
          Length = 1439

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MINQMNQ 8
            M+NQ+NQ
Sbjct: 1268 MLNQLNQ 1274
>XP_006710332
          Length = 1442

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MINQMNQ 8
            M+NQ+NQ
Sbjct: 1271 MLNQLNQ 1277
>NP_689548
          Length = 531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SMINQMNQQ 9
           S+ NQ NQ+
Sbjct: 483 SLFNQKNQE 491
>NP_001268369
          Length = 457

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   INQMNQQ 9
           ++QMNQQ
Sbjct: 411 LSQMNQQ 417
>NP_068759
          Length = 440

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   INQMNQQ 9
           ++QMNQQ
Sbjct: 394 LSQMNQQ 400
>NP_001229852
          Length = 516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MINQMNQQ 9
           MIN+ N+Q
Sbjct: 311 MINKQNEQ 318
>NP_057175
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MINQMNQQ 9
           MIN+ N+Q
Sbjct: 359 MINKQNEQ 366
>NP_001037770
          Length = 467

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   INQMNQQ 9
           ++QMNQQ
Sbjct: 421 LSQMNQQ 427
>XP_005261682
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MINQMNQQ 9
           MIN+ N+Q
Sbjct: 261 MINKQNEQ 268
>XP_006724323
          Length = 580

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MINQMNQQ 9
           MIN+ N+Q
Sbjct: 402 MINKQNEQ 409
>XP_005254217
          Length = 347

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SMINQMNQQ 9
           S+ NQ NQ+
Sbjct: 299 SLFNQKNQE 307
>NP_055950
          Length = 2012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SMINQMN 7
            SM+NQM+
Sbjct: 1108 SMLNQMS 1114
>NP_001138295
          Length = 1906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    MINQMNQQ 9
            M+N++NQ+
Sbjct: 1086 MLNRINQE 1093
>NP_005839
          Length = 1863

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    MINQMNQQ 9
            M+N++NQ+
Sbjct: 1043 MLNRINQE 1050
>NP_055797
          Length = 2341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    SMINQM 6
            SM+NQM
Sbjct: 2170 SMVNQM 2175
>NP_060063
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   MINQMNQQ 9
           ++NQMN++
Sbjct: 138 VVNQMNKK 145
>NP_942595
          Length = 1161

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   MINQMNQQ 9
           ++NQMN++
Sbjct: 138 VVNQMNKK 145
>XP_005254179
          Length = 1173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   MINQMNQQ 9
           M+N++NQ+
Sbjct: 353 MLNRINQE 360
>XP_005254178
          Length = 1863

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    MINQMNQQ 9
            M+N++NQ+
Sbjct: 1043 MLNRINQE 1050
>XP_006720435
          Length = 1907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    MINQMNQQ 9
            M+N++NQ+
Sbjct: 1087 MLNRINQE 1094
>XP_005254177
          Length = 1907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    MINQMNQQ 9
            M+N++NQ+
Sbjct: 1087 MLNRINQE 1094
>XP_006720434
          Length = 1907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    MINQMNQQ 9
            M+N++NQ+
Sbjct: 1087 MLNRINQE 1094
>XP_005254176
          Length = 1907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    MINQMNQQ 9
            M+N++NQ+
Sbjct: 1087 MLNRINQE 1094
>XP_005267486
          Length = 1421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    SMINQM 6
            SM+NQM
Sbjct: 1250 SMVNQM 1255
>XP_006720145
          Length = 1423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    SMINQM 6
            SM+NQM
Sbjct: 1252 SMVNQM 1257
>XP_005267485
          Length = 1459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    SMINQM 6
            SM+NQM
Sbjct: 1288 SMVNQM 1293
>XP_005267483
          Length = 2230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    SMINQM 6
            SM+NQM
Sbjct: 2059 SMVNQM 2064
>XP_005267482
          Length = 2243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    SMINQM 6
            SM+NQM
Sbjct: 2072 SMVNQM 2077
>XP_005267481
          Length = 2293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    SMINQM 6
            SM+NQM
Sbjct: 2122 SMVNQM 2127
>XP_005267480
          Length = 2336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    SMINQM 6
            SM+NQM
Sbjct: 2165 SMVNQM 2170
>XP_005267479
          Length = 2344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    SMINQM 6
            SM+NQM
Sbjct: 2173 SMVNQM 2178
>XP_005267478
          Length = 2348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    SMINQM 6
            SM+NQM
Sbjct: 2177 SMVNQM 2182
>XP_005267477
          Length = 2349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    SMINQM 6
            SM+NQM
Sbjct: 2178 SMVNQM 2183
>XP_005250292
          Length = 1654

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SMINQMN 7
           SM+NQM+
Sbjct: 750 SMLNQMS 756
>XP_005263174
          Length = 1124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   MINQMNQQ 9
           ++NQMN++
Sbjct: 138 VVNQMNKK 145
>NP_001116437
          Length = 784

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   SMINQMNQQ 9
           S  NQ NQQ
Sbjct: 257 SHFNQTNQQ 265
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.110    0.264 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 320,002
Number of extensions: 400
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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