Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_714544                                                              17    4312
XP_006720470                                                           17    4312
NP_001497                                                              16    5631
NP_663791                                                              16    5631
NP_663783                                                              16    5631
XP_006711403                                                           16    7355
NP_653300                                                              16    7355
NP_056069                                                              15    9605
NP_001013679                                                           15    9605
NP_940873                                                              15    9605
XP_006722781                                                           15    9605
XP_005272524                                                           15    9605
XP_006716380                                                           15    9605
XP_006716379                                                           15    9605
XP_005273516                                                           15    9605
XP_005273515                                                           15    9605
>NP_714544
          Length = 1775

 Score = 16.5 bits (31), Expect =  4312
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLTSALAVA 9
            SLTSA AVA
Sbjct: 1707 SLTSAQAVA 1715
>XP_006720470
          Length = 1017

 Score = 16.5 bits (31), Expect =  4312
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SLTSALAVA 9
           SLTSA AVA
Sbjct: 949 SLTSAQAVA 957
>NP_001497
          Length = 356

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SLTSALAVA 9
           SLTSALA A
Sbjct: 330 SLTSALARA 338
>NP_663791
          Length = 192

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   SLTSALAV 8
           SLT+ALAV
Sbjct: 163 SLTAALAV 170
>NP_663783
          Length = 191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   SLTSALAV 8
           SLT+ALAV
Sbjct: 162 SLTAALAV 169
>XP_006711403
          Length = 961

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   SLTSALAV 8
           SLTS LAV
Sbjct: 212 SLTSGLAV 219
>NP_653300
          Length = 1029

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   SLTSALAV 8
           SLTS LAV
Sbjct: 280 SLTSGLAV 287
>NP_056069
          Length = 1826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    SLTSALAVA 9
            SLT+ALA A
Sbjct: 1803 SLTAALAKA 1811
>NP_001013679
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SLTSALAVA 9
           SLT A AVA
Sbjct: 349 SLTEAAAVA 357
>NP_940873
          Length = 821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TSALAVA 9
           TSALA+A
Sbjct: 764 TSALAIA 770
>XP_006722781
          Length = 821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TSALAVA 9
           TSALA+A
Sbjct: 764 TSALAIA 770
>XP_005272524
          Length = 872

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TSALAVA 9
           TSALA+A
Sbjct: 815 TSALAIA 821
>XP_006716380
          Length = 1762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    SLTSALAVA 9
            SLT+ALA A
Sbjct: 1739 SLTAALAKA 1747
>XP_006716379
          Length = 1762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    SLTSALAVA 9
            SLT+ALA A
Sbjct: 1739 SLTAALAKA 1747
>XP_005273516
          Length = 1762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    SLTSALAVA 9
            SLT+ALA A
Sbjct: 1739 SLTAALAKA 1747
>XP_005273515
          Length = 1805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    SLTSALAVA 9
            SLT+ALA A
Sbjct: 1782 SLTAALAKA 1790
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.107    0.226 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 192,608
Number of extensions: 157
Number of successful extensions: 16
Number of sequences better than 10000.0: 16
Number of HSP's gapped: 16
Number of HSP's successfully gapped: 16
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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