Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              18    1135
XP_005262424                                                           18    1135
NP_001138462                                                           17    3301
NP_001257452                                                           16    5631
NP_001257453                                                           16    5631
NP_758840                                                              16    5631
NP_068374                                                              16    5631
NP_001257454                                                           16    5631
NP_001248348                                                           16    7355
NP_004624                                                              16    7355
NP_056028                                                              16    7355
NP_001230183                                                           16    7355
XP_006718232                                                           16    7355
XP_005252889                                                           16    7355
XP_006712799                                                           16    7355
XP_006712798                                                           16    7355
XP_006712797                                                           16    7355
XP_006712796                                                           16    7355
NP_001018098                                                           15    9605
NP_060154                                                              15    9605
NP_060550                                                              15    9605
NP_060542                                                              15    9605
NP_065872                                                              15    9605
NP_057381                                                              15    9605
NP_001092882                                                           15    9605
NP_006757                                                              15    9605
NP_001092883                                                           15    9605
NP_056128                                                              15    9605
NP_001185594                                                           15    9605
NP_849143                                                              15    9605
NP_001020260                                                           15    9605
NP_001020259                                                           15    9605
NP_001020258                                                           15    9605
NP_064565                                                              15    9605
NP_004834                                                              15    9605
XP_006722571                                                           15    9605
XP_006722570                                                           15    9605
XP_006722569                                                           15    9605
XP_006722568                                                           15    9605
XP_005258365                                                           15    9605
XP_006722567                                                           15    9605
XP_005271537                                                           15    9605
XP_005271535                                                           15    9605
XP_006718868                                                           15    9605
XP_005273706                                                           15    9605
>NP_722576
          Length = 3080

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SLSLSTSGL 9
            SLSLST+GL
Sbjct: 1465 SLSLSTAGL 1473
>XP_005262424
          Length = 2875

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SLSLSTSGL 9
            SLSLST+GL
Sbjct: 1260 SLSLSTAGL 1268
>NP_001138462
          Length = 1742

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    LSLSTSGL 9
            LSLSTSG+
Sbjct: 1290 LSLSTSGV 1297
>NP_001257452
          Length = 289

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LSLSTSGL 9
          LSL+TSG+
Sbjct: 15 LSLTTSGM 22
>NP_001257453
          Length = 289

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LSLSTSGL 9
          LSL+TSG+
Sbjct: 15 LSLTTSGM 22
>NP_758840
          Length = 289

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LSLSTSGL 9
          LSL+TSG+
Sbjct: 15 LSLTTSGM 22
>NP_068374
          Length = 297

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LSLSTSGL 9
          LSL+TSG+
Sbjct: 15 LSLTTSGM 22
>NP_001257454
          Length = 297

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LSLSTSGL 9
          LSL+TSG+
Sbjct: 15 LSLTTSGM 22
>NP_001248348
          Length = 296

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LSLSTSGL 9
           L+LSTSG+
Sbjct: 142 LTLSTSGV 149
>NP_004624
          Length = 398

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LSLSTSGL 9
           L+LSTSG+
Sbjct: 142 LTLSTSGV 149
>NP_056028
          Length = 1287

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SLSTSGL 9
           SLSTSG+
Sbjct: 836 SLSTSGI 842
>NP_001230183
          Length = 1241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SLSTSGL 9
           SLSTSG+
Sbjct: 836 SLSTSGI 842
>XP_006718232
          Length = 1263

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SLSTSGL 9
           SLSTSG+
Sbjct: 812 SLSTSGI 818
>XP_005252889
          Length = 1307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SLSTSGL 9
           SLSTSG+
Sbjct: 836 SLSTSGI 842
>XP_006712799
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LSLSTSGL 9
           L+LSTSG+
Sbjct: 167 LTLSTSGV 174
>XP_006712798
          Length = 313

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LSLSTSGL 9
          L+LSTSG+
Sbjct: 57 LTLSTSGV 64
>XP_006712797
          Length = 398

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LSLSTSGL 9
           L+LSTSG+
Sbjct: 142 LTLSTSGV 149
>XP_006712796
          Length = 402

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LSLSTSGL 9
           L+LSTSG+
Sbjct: 167 LTLSTSGV 174
>NP_001018098
          Length = 3628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    SLSLSTSGL 9
            +LSLSTS L
Sbjct: 2135 NLSLSTSKL 2143
>NP_060154
          Length = 3710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    SLSLSTSGL 9
            +LSLSTS L
Sbjct: 2092 NLSLSTSKL 2100
>NP_060550
          Length = 3585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    SLSLSTSGL 9
            +LSLSTS L
Sbjct: 2092 NLSLSTSKL 2100
>NP_060542
          Length = 2144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LSLSTSG 8
           +SLSTSG
Sbjct: 464 VSLSTSG 470
>NP_065872
          Length = 3753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    SLSLSTSGL 9
            +LSLSTS L
Sbjct: 2135 NLSLSTSKL 2143
>NP_057381
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SLSLSTSGL 9
           SLS S SGL
Sbjct: 239 SLSCSDSGL 247
>NP_001092882
          Length = 2004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SLSLSTSGL 9
            S+SLS +GL
Sbjct: 1783 SVSLSNTGL 1791
>NP_006757
          Length = 2004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SLSLSTSGL 9
            S+SLS +GL
Sbjct: 1783 SVSLSNTGL 1791
>NP_001092883
          Length = 2004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SLSLSTSGL 9
            S+SLS +GL
Sbjct: 1783 SVSLSNTGL 1791
>NP_056128
          Length = 1544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    SLSLSTSG 8
            S SLSTSG
Sbjct: 1194 SHSLSTSG 1201
>NP_001185594
          Length = 1525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    SLSLSTSG 8
            S SLSTSG
Sbjct: 1175 SHSLSTSG 1182
>NP_849143
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SLSLSTSG 8
           SLS +TSG
Sbjct: 224 SLSFNTSG 231
>NP_001020260
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  SLSTSGL 9
          SLST+GL
Sbjct: 17 SLSTNGL 23
>NP_001020259
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  SLSTSGL 9
          SLST+GL
Sbjct: 17 SLSTNGL 23
>NP_001020258
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  SLSTSGL 9
          SLST+GL
Sbjct: 17 SLSTNGL 23
>NP_064565
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  SLSTSGL 9
          SLST+GL
Sbjct: 17 SLSTNGL 23
>NP_004834
          Length = 636

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LSLSTSG 8
           LSL+TSG
Sbjct: 534 LSLATSG 540
>XP_006722571
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  SLSTSGL 9
          SLST+GL
Sbjct: 17 SLSTNGL 23
>XP_006722570
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  SLSTSGL 9
          SLST+GL
Sbjct: 17 SLSTNGL 23
>XP_006722569
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  SLSTSGL 9
          SLST+GL
Sbjct: 17 SLSTNGL 23
>XP_006722568
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  SLSTSGL 9
          SLST+GL
Sbjct: 17 SLSTNGL 23
>XP_005258365
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  SLSTSGL 9
          SLST+GL
Sbjct: 17 SLSTNGL 23
>XP_006722567
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  SLSTSGL 9
          SLST+GL
Sbjct: 17 SLSTNGL 23
>XP_005271537
          Length = 1441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    SLSLSTSG 8
            S SLSTSG
Sbjct: 1091 SHSLSTSG 1098
>XP_005271535
          Length = 1504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    SLSLSTSG 8
            S SLSTSG
Sbjct: 1154 SHSLSTSG 1161
>XP_006718868
          Length = 1519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    SLSLSTSG 8
            S SLSTSG
Sbjct: 1169 SHSLSTSG 1176
>XP_005273706
          Length = 1997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SLSLSTSGL 9
            S+SLS +GL
Sbjct: 1776 SVSLSNTGL 1784
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.295    0.112    0.251 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 370,980
Number of extensions: 655
Number of successful extensions: 45
Number of sequences better than 10000.0: 45
Number of HSP's gapped: 45
Number of HSP's successfully gapped: 45
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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