Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000312                                                              20     390
NP_899662                                                              18    1935
NP_002886                                                              18    1935
XP_006723905                                                           18    1935
NP_005602                                                              17    2528
XP_005256140                                                           17    2528
NP_694962                                                              17    3301
NP_001892                                                              16    5631
NP_075069                                                              16    5631
NP_001162195                                                           16    5631
XP_003960172                                                           16    5631
XP_006718731                                                           16    5631
XP_006718730                                                           16    5631
XP_003119008                                                           16    5631
XP_003119853                                                           16    5631
NP_002652                                                              16    7355
NP_055524                                                              16    7355
NP_001164632                                                           16    7355
NP_001164630                                                           16    7355
NP_001164629                                                           16    7355
NP_001164628                                                           16    7355
NP_005551                                                              16    7355
XP_006723861                                                           16    7355
XP_006723860                                                           16    7355
XP_006723859                                                           16    7355
XP_005259426                                                           16    7355
XP_005247480                                                           16    7355
XP_005247479                                                           16    7355
NP_872416                                                              16    7355
NP_001017415                                                           16    7355
NP_003359                                                              16    7355
NP_001017416                                                           16    7355
NP_115642                                                              15    9605
NP_004786                                                              15    9605
NP_001159716                                                           15    9605
NP_001159718                                                           15    9605
NP_068600                                                              15    9605
NP_001159717                                                           15    9605
NP_114434                                                              15    9605
NP_001034659                                                           15    9605
NP_001633                                                              15    9605
NP_001230228                                                           15    9605
XP_006719958                                                           15    9605
XP_006718000                                                           15    9605
NP_001135748                                                           15    9605
NP_006811                                                              15    9605
NP_001135749                                                           15    9605
NP_001135750                                                           15    9605
>NP_000312
          Length = 928

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SLSLFYKKM 9
           SLSLFYKK+
Sbjct: 646 SLSLFYKKV 654
>NP_899662
          Length = 1014

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLSLFYKKM 9
           SL+LFY+K+
Sbjct: 787 SLALFYRKV 795
>NP_002886
          Length = 1068

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLSLFYKKM 9
           SL+LFY+K+
Sbjct: 787 SLALFYRKV 795
>XP_006723905
          Length = 896

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLSLFYKKM 9
           SL+LFY+K+
Sbjct: 615 SLALFYRKV 623
>NP_005602
          Length = 1139

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLSLFYKKM 9
           SLSLF++K+
Sbjct: 835 SLSLFFRKV 843
>XP_005256140
          Length = 1065

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLSLFYKKM 9
           SLSLF++K+
Sbjct: 761 SLSLFFRKV 769
>NP_694962
          Length = 442

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SLSLFYKKM 9
           SLS F KKM
Sbjct: 152 SLSFFLKKM 160
>NP_001892
          Length = 349

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SLFYKKM 9
           SL+Y+KM
Sbjct: 338 SLYYRKM 344
>NP_075069
          Length = 458

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LSLFYKK 8
           LSLFY K
Sbjct: 289 LSLFYNK 295
>NP_001162195
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LSLFYKK 8
           LSLFY K
Sbjct: 267 LSLFYNK 273
>XP_003960172
          Length = 459

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLFYKKM 9
           L L+YKK+
Sbjct: 367 LELYYKKL 374
>XP_006718731
          Length = 330

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LSLFYKK 8
           LSLFY K
Sbjct: 161 LSLFYNK 167
>XP_006718730
          Length = 343

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LSLFYKK 8
           LSLFY K
Sbjct: 174 LSLFYNK 180
>XP_003119008
          Length = 459

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLFYKKM 9
           L L+YKK+
Sbjct: 367 LELYYKKL 374
>XP_003119853
          Length = 459

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLFYKKM 9
           L L+YKK+
Sbjct: 367 LELYYKKL 374
>NP_002652
          Length = 1265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LFYKKM 9
           LFYKK+
Sbjct: 204 LFYKKL 209
>NP_055524
          Length = 3546

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LFYKKM 9
            LFYK+M
Sbjct: 2234 LFYKRM 2239
>NP_001164632
          Length = 454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SLSLFYKK 8
           SLS+ YKK
Sbjct: 291 SLSVHYKK 298
>NP_001164630
          Length = 544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SLSLFYKK 8
           SLS+ YKK
Sbjct: 381 SLSVHYKK 388
>NP_001164629
          Length = 554

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SLSLFYKK 8
           SLS+ YKK
Sbjct: 391 SLSVHYKK 398
>NP_001164628
          Length = 602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SLSLFYKK 8
           SLS+ YKK
Sbjct: 439 SLSVHYKK 446
>NP_005551
          Length = 3695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SLSLFY 6
            SLSLFY
Sbjct: 1426 SLSLFY 1431
>XP_006723861
          Length = 2300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SLSLFY 6
            SLSLFY
Sbjct: 1426 SLSLFY 1431
>XP_006723860
          Length = 2586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SLSLFY 6
            SLSLFY
Sbjct: 1426 SLSLFY 1431
>XP_006723859
          Length = 3700

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SLSLFY 6
            SLSLFY
Sbjct: 1426 SLSLFY 1431
>XP_005259426
          Length = 512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SLSLFYKK 8
           SLS+ YKK
Sbjct: 349 SLSVHYKK 356
>XP_005247480
          Length = 347

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   SLFYKK 8
           S+FYKK
Sbjct: 292 SMFYKK 297
>XP_005247479
          Length = 446

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   SLFYKK 8
           S+FYKK
Sbjct: 391 SMFYKK 396
>NP_872416
          Length = 446

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   SLFYKK 8
           S+FYKK
Sbjct: 391 SMFYKK 396
>NP_001017415
          Length = 785

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LFYKKM 9
           LFYKK+
Sbjct: 780 LFYKKL 785
>NP_003359
          Length = 785

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LFYKKM 9
           LFYKK+
Sbjct: 780 LFYKKL 785
>NP_001017416
          Length = 785

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LFYKKM 9
           LFYKK+
Sbjct: 780 LFYKKL 785
>NP_115642
          Length = 1984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SLSLFYKK 8
            SLS+FY +
Sbjct: 1033 SLSIFYDR 1040
>NP_004786
          Length = 1012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SLSLFYKKM 9
           S +LFY+K+
Sbjct: 492 SSALFYQKL 500
>NP_001159716
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLFYKKM 9
           LSL YK++
Sbjct: 386 LSLLYKRL 393
>NP_001159718
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLFYKKM 9
           LSL YK++
Sbjct: 444 LSLLYKRL 451
>NP_068600
          Length = 592

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLFYKKM 9
           LSL YK++
Sbjct: 444 LSLLYKRL 451
>NP_001159717
          Length = 480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLFYKKM 9
           LSL YK++
Sbjct: 332 LSLLYKRL 339
>NP_114434
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SLSLFYKKM 9
           S+S+F KK+
Sbjct: 452 SISIFKKKL 460
>NP_001034659
          Length = 458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SLSLFYKKM 9
           S+S+F KK+
Sbjct: 435 SISIFKKKL 443
>NP_001633
          Length = 763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SLSLFYK 7
           SLSL YK
Sbjct: 543 SLSLLYK 549
>NP_001230228
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SLSLFYK 7
           SLSL YK
Sbjct: 553 SLSLLYK 559
>XP_006719958
          Length = 705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SLSLFYKKM 9
           S +LFY+K+
Sbjct: 185 SSALFYQKL 193
>XP_006718000
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLFYKKM 9
           LSL YK++
Sbjct: 272 LSLLYKRL 279
>NP_001135748
          Length = 751

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SLSLFYK 7
           SLSL YK
Sbjct: 543 SLSLLYK 549
>NP_006811
          Length = 452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  SLSLFYK 7
          SLSL YK
Sbjct: 23 SLSLLYK 29
>NP_001135749
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SLSLFYK 7
           SLSL YK
Sbjct: 487 SLSLLYK 493
>NP_001135750
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SLSLFYK 7
           SLSL YK
Sbjct: 314 SLSLLYK 320
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.135    0.357 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 471,406
Number of extensions: 544
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package