Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004295                                                              19     665
NP_001092108                                                           17    4312
NP_006181                                                              17    4312
XP_006712618                                                           17    4312
NP_000114                                                              16    5631
NP_001271308                                                           16    5631
NP_001271306                                                           16    5631
NP_001191354                                                           16    5631
XP_005255623                                                           16    5631
XP_005254569                                                           16    5631
XP_006710483                                                           16    5631
NP_076936                                                              16    5631
NP_001012270                                                           16    7355
NP_004769                                                              16    7355
NP_065939                                                              16    7355
NP_001185901                                                           16    7355
XP_006710855                                                           16    7355
XP_006710854                                                           16    7355
NP_000929                                                              16    7355
NP_001258593                                                           15    9605
NP_001138476                                                           15    9605
NP_001257449                                                           15    9605
NP_001539                                                              15    9605
NP_055807                                                              15    9605
NP_001257856                                                           15    9605
NP_001257859                                                           15    9605
NP_001257857                                                           15    9605
NP_001028222                                                           15    9605
NP_001257858                                                           15    9605
NP_079474                                                              15    9605
NP_001271236                                                           15    9605
NP_001271235                                                           15    9605
NP_071918                                                              15    9605
NP_001074003                                                           15    9605
NP_001009                                                              15    9605
NP_001001413                                                           15    9605
NP_055646                                                              15    9605
XP_006726627                                                           15    9605
XP_006726626                                                           15    9605
XP_006726624                                                           15    9605
XP_006726623                                                           15    9605
XP_006725630                                                           15    9605
XP_006725629                                                           15    9605
XP_006725599                                                           15    9605
XP_006726291                                                           15    9605
XP_006726290                                                           15    9605
XP_006725238                                                           15    9605
XP_006720863                                                           15    9605
XP_006720862                                                           15    9605
XP_003846401                                                           15    9605
XP_002343363                                                           15    9605
XP_006720860                                                           15    9605
XP_006720859                                                           15    9605
XP_006720858                                                           15    9605
XP_005254649                                                           15    9605
XP_005254648                                                           15    9605
XP_005254452                                                           15    9605
XP_005254451                                                           15    9605
XP_006720426                                                           15    9605
XP_005267488                                                           15    9605
XP_005267487                                                           15    9605
XP_006719676                                                           15    9605
XP_006719675                                                           15    9605
XP_006713495                                                           15    9605
>NP_004295
          Length = 1620

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SLRKLRRAK 9
           S+RKLRRAK
Sbjct: 131 SVRKLRRAK 139
>NP_001092108
          Length = 708

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SLRKLRRAK 9
           SLRKLR  K
Sbjct: 189 SLRKLREEK 197
>NP_006181
          Length = 577

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLRKLRRAK 9
           +L+KL+RAK
Sbjct: 258 TLQKLKRAK 266
>XP_006712618
          Length = 577

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLRKLRRAK 9
           +L+KL+RAK
Sbjct: 258 TLQKLKRAK 266
>NP_000114
          Length = 1186

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    RKLRRAK 9
            RKLRRA+
Sbjct: 1174 RKLRRAR 1180
>NP_001271308
          Length = 146

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLRKLRRAK 9
           SLRKL++A+
Sbjct: 131 SLRKLKQAQ 139
>NP_001271306
          Length = 140

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLRKLRRAK 9
           SLRKL++A+
Sbjct: 125 SLRKLKQAQ 133
>NP_001191354
          Length = 1640

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    RKLRRAK 9
            RKLRRA+
Sbjct: 1628 RKLRRAR 1634
>XP_005255623
          Length = 585

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   SLRKLRRA 8
           S RKLRRA
Sbjct: 513 SSRKLRRA 520
>XP_005254569
          Length = 167

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLRKLRRAK 9
           SLRKL++A+
Sbjct: 152 SLRKLKQAQ 160
>XP_006710483
          Length = 295

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SLRKLRRAK 9
          SLRKL++ K
Sbjct: 44 SLRKLKQTK 52
>NP_076936
          Length = 585

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   SLRKLRRA 8
           S RKLRRA
Sbjct: 513 SSRKLRRA 520
>NP_001012270
          Length = 137

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  SLRKLRR 7
          +LRKLRR
Sbjct: 84 NLRKLRR 90
>NP_004769
          Length = 395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LRKLRRA 8
           LRKLRR+
Sbjct: 312 LRKLRRS 318
>NP_065939
          Length = 1094

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SLRKLRR 7
           SLRKL+R
Sbjct: 490 SLRKLKR 496
>NP_001185901
          Length = 1035

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SLRKLRR 7
           SLRKL+R
Sbjct: 431 SLRKLKR 437
>XP_006710855
          Length = 821

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SLRKLRR 7
           SLRKL+R
Sbjct: 217 SLRKLKR 223
>XP_006710854
          Length = 1046

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SLRKLRR 7
           SLRKL+R
Sbjct: 442 SLRKLKR 448
>NP_000929
          Length = 1174

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SLRKLRR 7
           +LRKLRR
Sbjct: 586 TLRKLRR 592
>NP_001258593
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 237 RKLERAK 243
>NP_001138476
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 237 RKLERAK 243
>NP_001257449
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RKLRRAK 9
            RK+R+AK
Sbjct: 1008 RKMRKAK 1014
>NP_001539
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRKLRR 7
           LRKLRR
Sbjct: 427 LRKLRR 432
>NP_055807
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RKLRRAK 9
            RK+R+AK
Sbjct: 1018 RKMRKAK 1024
>NP_001257856
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRKLRR 7
           LRKLRR
Sbjct: 427 LRKLRR 432
>NP_001257859
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRKLRR 7
           LRKLRR
Sbjct: 396 LRKLRR 401
>NP_001257857
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRKLRR 7
           LRKLRR
Sbjct: 396 LRKLRR 401
>NP_001028222
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LRKLRRAK 9
          +RK+RR K
Sbjct: 59 IRKIRRLK 66
>NP_001257858
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRKLRR 7
           LRKLRR
Sbjct: 396 LRKLRR 401
>NP_079474
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LRKLRRAK 9
          +RK+RR K
Sbjct: 59 IRKIRRLK 66
>NP_001271236
          Length = 1111

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SLRKLRRA 8
           S+RK RRA
Sbjct: 241 SIRKKRRA 248
>NP_001271235
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SLRKLRRA 8
           S+RK RRA
Sbjct: 198 SIRKKRRA 205
>NP_071918
          Length = 1883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SLRKLRRA 8
            S+RK RRA
Sbjct: 1013 SIRKKRRA 1020
>NP_001074003
          Length = 2214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLRKLRRAK 9
           +LRKLR+ K
Sbjct: 180 ALRKLRKWK 188
>NP_001009
          Length = 145

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LRKLRRAK 9
          L++LR+AK
Sbjct: 57 LKRLRKAK 64
>NP_001001413
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 249 RKLERAK 255
>NP_055646
          Length = 2925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    RKLRRA 8
            RKLRRA
Sbjct: 2677 RKLRRA 2682
>XP_006726627
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 252 RKLERAK 258
>XP_006726626
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 225 RKLERAK 231
>XP_006726624
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 231 RKLERAK 237
>XP_006726623
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 231 RKLERAK 237
>XP_006725630
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 231 RKLERAK 237
>XP_006725629
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 231 RKLERAK 237
>XP_006725599
          Length = 466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 249 RKLERAK 255
>XP_006726291
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 231 RKLERAK 237
>XP_006726290
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 231 RKLERAK 237
>XP_006725238
          Length = 466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 249 RKLERAK 255
>XP_006720863
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 231 RKLERAK 237
>XP_006720862
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 237 RKLERAK 243
>XP_003846401
          Length = 426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 253 RKLERAK 259
>XP_002343363
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 253 RKLERAK 259
>XP_006720860
          Length = 434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 225 RKLERAK 231
>XP_006720859
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 225 RKLERAK 231
>XP_006720858
          Length = 651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 225 RKLERAK 231
>XP_005254649
          Length = 1819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SLRKLRRA 8
            S+RK RRA
Sbjct: 1036 SIRKKRRA 1043
>XP_005254648
          Length = 1906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SLRKLRRA 8
            S+RK RRA
Sbjct: 1036 SIRKKRRA 1043
>XP_005254452
          Length = 2188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLRKLRRAK 9
           +LRKLR+ K
Sbjct: 180 ALRKLRKWK 188
>XP_005254451
          Length = 2214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLRKLRRAK 9
           +LRKLR+ K
Sbjct: 180 ALRKLRKWK 188
>XP_006720426
          Length = 466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RKLRRAK 9
           RKL RAK
Sbjct: 249 RKLERAK 255
>XP_005267488
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RKLRRAK 9
            RK+R+AK
Sbjct: 1018 RKMRKAK 1024
>XP_005267487
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RKLRRAK 9
            RK+R+AK
Sbjct: 1018 RKMRKAK 1024
>XP_006719676
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LRKLRRAK 9
          +RK+RR K
Sbjct: 59 IRKIRRLK 66
>XP_006719675
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LRKLRRAK 9
          +RK+RR K
Sbjct: 59 IRKIRRLK 66
>XP_006713495
          Length = 2969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    RKLRRA 8
            RKLRRA
Sbjct: 2721 RKLRRA 2726
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.134    0.326 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 439,125
Number of extensions: 770
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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