Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           20     390
NP_004561                                                              20     390
XP_005253450                                                           20     390
XP_006719151                                                           20     390
XP_006710801                                                           18    1935
NP_060681                                                              17    3301
NP_001091982                                                           17    4312
NP_006249                                                              17    4312
XP_005270029                                                           17    4312
XP_005270028                                                           17    4312
XP_005270027                                                           17    4312
NP_001161210                                                           16    5631
NP_065176                                                              16    5631
NP_005566                                                              16    5631
NP_787116                                                              16    5631
NP_078867                                                              16    5631
NP_061187                                                              16    5631
XP_005257725                                                           16    5631
XP_006711674                                                           16    5631
XP_006711673                                                           16    5631
XP_006711672                                                           16    5631
XP_006711671                                                           16    5631
XP_006711670                                                           16    5631
XP_005245629                                                           16    5631
NP_001367                                                              16    7355
NP_689594                                                              16    7355
XP_006712319                                                           16    7355
NP_001186073                                                           16    7355
NP_005484                                                              15    9605
NP_001139753                                                           15    9605
NP_001139751                                                           15    9605
NP_001276045                                                           15    9605
NP_001276042                                                           15    9605
NP_001276043                                                           15    9605
NP_001031                                                              15    9605
NP_001257903                                                           15    9605
NP_620830                                                              15    9605
NP_001185835                                                           15    9605
NP_001185834                                                           15    9605
NP_001185833                                                           15    9605
NP_001185832                                                           15    9605
NP_001185831                                                           15    9605
NP_001185829                                                           15    9605
NP_001185828                                                           15    9605
NP_060212                                                              15    9605
NP_378669                                                              15    9605
NP_060723                                                              15    9605
NP_001185830                                                           15    9605
XP_006722557                                                           15    9605
XP_006722556                                                           15    9605
XP_005256822                                                           15    9605
XP_006721632                                                           15    9605
XP_006721269                                                           15    9605
XP_006715008                                                           15    9605
XP_006711497                                                           15    9605
XP_006711496                                                           15    9605
XP_006711495                                                           15    9605
NP_620829                                                              15    9605
NP_056229                                                              15    9605
>NP_001275701
          Length = 1486

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  SLNKAHQIS 9
          SLN+AHQIS
Sbjct: 77 SLNEAHQIS 85
>NP_004561
          Length = 1445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  SLNKAHQIS 9
          SLN+AHQIS
Sbjct: 77 SLNEAHQIS 85
>XP_005253450
          Length = 1486

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  SLNKAHQIS 9
          SLN+AHQIS
Sbjct: 77 SLNEAHQIS 85
>XP_006719151
          Length = 1486

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  SLNKAHQIS 9
          SLN+AHQIS
Sbjct: 77 SLNEAHQIS 85
>XP_006710801
          Length = 647

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LNKAHQIS 9
           LNKAHQ S
Sbjct: 348 LNKAHQSS 355
>NP_060681
          Length = 678

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LNKAHQ 7
           LNKAHQ
Sbjct: 392 LNKAHQ 397
>NP_001091982
          Length = 671

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LNKAHQIS 9
           LNK H IS
Sbjct: 531 LNKGHDIS 538
>NP_006249
          Length = 686

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LNKAHQIS 9
           LNK H IS
Sbjct: 546 LNKGHDIS 553
>XP_005270029
          Length = 403

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LNKAHQIS 9
           LNK H IS
Sbjct: 263 LNKGHDIS 270
>XP_005270028
          Length = 591

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LNKAHQIS 9
           LNK H IS
Sbjct: 451 LNKGHDIS 458
>XP_005270027
          Length = 665

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LNKAHQIS 9
           LNK H IS
Sbjct: 546 LNKGHDIS 553
>NP_001161210
          Length = 1483

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SLNKAHQI 8
           +LN AHQ+
Sbjct: 934 ALNSAHQL 941
>NP_065176
          Length = 1877

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SLNKAHQI 8
            +LN AHQ+
Sbjct: 1328 ALNSAHQL 1335
>NP_005566
          Length = 1025

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLNKAHQIS 9
           SLN +H IS
Sbjct: 523 SLNSSHPIS 531
>NP_787116
          Length = 1011

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLNKAHQIS 9
           SLN +H IS
Sbjct: 509 SLNSSHPIS 517
>NP_078867
          Length = 201

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LNKAHQI 8
           LNK HQ+
Sbjct: 111 LNKMHQV 117
>NP_061187
          Length = 1133

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SLNKAHQI 8
           SLNK H I
Sbjct: 585 SLNKQHNI 592
>XP_005257725
          Length = 245

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LNKAHQI 8
           LNK HQ+
Sbjct: 111 LNKMHQV 117
>XP_006711674
          Length = 1385

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SLNKAHQI 8
           +LN AHQ+
Sbjct: 836 ALNSAHQL 843
>XP_006711673
          Length = 1549

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SLNKAHQI 8
            +LN AHQ+
Sbjct: 1000 ALNSAHQL 1007
>XP_006711672
          Length = 1557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SLNKAHQI 8
            +LN AHQ+
Sbjct: 1008 ALNSAHQL 1015
>XP_006711671
          Length = 2153

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SLNKAHQI 8
            +LN AHQ+
Sbjct: 1604 ALNSAHQL 1611
>XP_006711670
          Length = 2161

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SLNKAHQI 8
            +LN AHQ+
Sbjct: 1612 ALNSAHQL 1619
>XP_005245629
          Length = 2164

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SLNKAHQI 8
            +LN AHQ+
Sbjct: 1615 ALNSAHQL 1622
>NP_001367
          Length = 4646

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNKAHQ 7
           +NKAHQ
Sbjct: 765 VNKAHQ 770
>NP_689594
          Length = 3549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SLNKAHQ 7
           S+NK HQ
Sbjct: 665 SMNKMHQ 671
>XP_006712319
          Length = 3308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SLNKAHQ 7
           S+NK HQ
Sbjct: 424 SMNKMHQ 430
>NP_001186073
          Length = 3327

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SLNKAHQ 7
           S+NK HQ
Sbjct: 443 SMNKMHQ 449
>NP_005484
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   NKAHQ 7
           NKAHQ
Sbjct: 520 NKAHQ 524
>NP_001139753
          Length = 287

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SLNKAHQI 8
           +LN++H+I
Sbjct: 263 ALNRSHEI 270
>NP_001139751
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SLNKAHQI 8
           +LN++H+I
Sbjct: 360 ALNRSHEI 367
>NP_001276045
          Length = 286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SLNKAHQI 8
           +LN++H+I
Sbjct: 262 ALNRSHEI 269
>NP_001276042
          Length = 344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SLNKAHQI 8
           +LN++H+I
Sbjct: 320 ALNRSHEI 327
>NP_001276043
          Length = 344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SLNKAHQI 8
           +LN++H+I
Sbjct: 320 ALNRSHEI 327
>NP_001031
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SLNKAHQI 8
           +LN++H+I
Sbjct: 378 ALNRSHEI 385
>NP_001257903
          Length = 5121

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    SLNKAH 6
            SLNK+H
Sbjct: 4085 SLNKSH 4090
>NP_620830
          Length = 750

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LNKAHQIS 9
          LN+ HQI+
Sbjct: 51 LNEQHQIA 58
>NP_001185835
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LNKAHQIS 9
           LN+ HQI+
Sbjct: 117 LNEQHQIA 124
>NP_001185834
          Length = 730

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LNKAHQIS 9
          LN+ HQI+
Sbjct: 51 LNEQHQIA 58
>NP_001185833
          Length = 868

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LNKAHQIS 9
           LN+ HQI+
Sbjct: 189 LNEQHQIA 196
>NP_001185832
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LNKAHQIS 9
           LN+ HQI+
Sbjct: 189 LNEQHQIA 196
>NP_001185831
          Length = 750

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LNKAHQIS 9
          LN+ HQI+
Sbjct: 51 LNEQHQIA 58
>NP_001185829
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LNKAHQIS 9
          LN+ HQI+
Sbjct: 40 LNEQHQIA 47
>NP_001185828
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LNKAHQIS 9
          LN+ HQI+
Sbjct: 40 LNEQHQIA 47
>NP_060212
          Length = 1178

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    LNKAHQ 7
            LN+AHQ
Sbjct: 1060 LNQAHQ 1065
>NP_378669
          Length = 105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  LNKAHQIS 9
          LNK H+++
Sbjct: 11 LNKGHKVT 18
>NP_060723
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LNKAHQIS 9
          LN+ HQI+
Sbjct: 40 LNEQHQIA 47
>NP_001185830
          Length = 750

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LNKAHQIS 9
          LN+ HQI+
Sbjct: 51 LNEQHQIA 58
>XP_006722557
          Length = 1076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNKAHQ 7
           LN+AHQ
Sbjct: 958 LNQAHQ 963
>XP_006722556
          Length = 1100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNKAHQ 7
           LN+AHQ
Sbjct: 982 LNQAHQ 987
>XP_005256822
          Length = 233

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SLNKAHQI 8
           +LN++H+I
Sbjct: 209 ALNRSHEI 216
>XP_006721632
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SLNKAHQI 8
           +LN++H+I
Sbjct: 324 ALNRSHEI 331
>XP_006721269
          Length = 5138

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    SLNKAH 6
            SLNK+H
Sbjct: 4102 SLNKSH 4107
>XP_006715008
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   NKAHQ 7
           NKAHQ
Sbjct: 291 NKAHQ 295
>XP_006711497
          Length = 701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LNKAHQIS 9
          LN+ HQI+
Sbjct: 51 LNEQHQIA 58
>XP_006711496
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LNKAHQIS 9
          LN+ HQI+
Sbjct: 40 LNEQHQIA 47
>XP_006711495
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LNKAHQIS 9
          LN+ HQI+
Sbjct: 51 LNEQHQIA 58
>NP_620829
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LNKAHQIS 9
           LN+ HQI+
Sbjct: 117 LNEQHQIA 124
>NP_056229
          Length = 105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  LNKAHQIS 9
          LNK H+++
Sbjct: 11 LNKGHKVT 18
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.305    0.112    0.282 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 543,056
Number of extensions: 885
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package