Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_073713                                                              20     390
NP_115486                                                              20     509
NP_001264198                                                           18    1935
NP_001005192                                                           17    2528
NP_060043                                                              17    2528
XP_005259643                                                           17    2528
XP_005259642                                                           17    2528
XP_005259640                                                           17    2528
NP_055769                                                              17    3301
NP_001137326                                                           17    3301
NP_001124435                                                           17    3301
NP_056072                                                              17    3301
NP_000375                                                              17    4312
NP_001278238                                                           17    4312
NP_612192                                                              17    4312
NP_002561                                                              17    4312
NP_001005280                                                           16    5631
NP_061824                                                              16    5631
NP_001005226                                                           16    5631
NP_644670                                                              16    5631
NP_006086                                                              16    5631
NP_001098999                                                           16    5631
NP_039229                                                              16    5631
XP_006714052                                                           16    5631
XP_005248100                                                           16    5631
NP_149046                                                              16    5631
NP_001007467                                                           16    7355
NP_064630                                                              16    7355
NP_787079                                                              16    7355
NP_001005191                                                           16    7355
NP_056081                                                              16    7355
NP_001247420                                                           16    7355
XP_006723821                                                           16    7355
XP_006723820                                                           16    7355
XP_006723819                                                           16    7355
XP_005267114                                                           16    7355
NP_003544                                                              16    7355
NP_003545                                                              16    7355
NP_036509                                                              16    7355
NP_001005190                                                           16    7355
NP_001001958                                                           16    7355
NP_001278220                                                           15    9605
NP_775082                                                              15    9605
NP_003377                                                              15    9605
NP_004906                                                              15    9605
NP_997511                                                              15    9605
NP_058198                                                              15    9605
NP_997512                                                              15    9605
NP_722523                                                              15    9605
NP_997510                                                              15    9605
NP_997057                                                              15    9605
NP_065201                                                              15    9605
XP_006722679                                                           15    9605
XP_005248797                                                           15    9605
XP_005248796                                                           15    9605
XP_005248795                                                           15    9605
>NP_073713
          Length = 985

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  SLMYGTAEG 9
          SL YGTAEG
Sbjct: 40 SLTYGTAEG 48
>NP_115486
          Length = 542

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   LMYGTAEG 9
           L+YGTAEG
Sbjct: 131 LLYGTAEG 138
>NP_001264198
          Length = 2925

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    MYGTAEG 9
            MYG+AEG
Sbjct: 1935 MYGSAEG 1941
>NP_001005192
          Length = 311

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SLMYGTAEG 9
           SL YGTA G
Sbjct: 249 SLFYGTAFG 257
>NP_060043
          Length = 755

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LMYGTAE 8
           L+YGTAE
Sbjct: 574 LLYGTAE 580
>XP_005259643
          Length = 567

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LMYGTAE 8
           L+YGTAE
Sbjct: 386 LLYGTAE 392
>XP_005259642
          Length = 617

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LMYGTAE 8
           L+YGTAE
Sbjct: 574 LLYGTAE 580
>XP_005259640
          Length = 746

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LMYGTAE 8
           L+YGTAE
Sbjct: 565 LLYGTAE 571
>NP_055769
          Length = 690

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLMYGTAEG 9
           SLMY T +G
Sbjct: 553 SLMYSTQQG 561
>NP_001137326
          Length = 694

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLMYGTAEG 9
           SLMY T +G
Sbjct: 557 SLMYSTQQG 565
>NP_001124435
          Length = 444

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LMYGTAE 8
          L+YGTAE
Sbjct: 38 LVYGTAE 44
>NP_056072
          Length = 371

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LMYGTAE 8
          L+YGTAE
Sbjct: 38 LVYGTAE 44
>NP_000375
          Length = 4563

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SLMYGTAEG 9
            S++Y TA+G
Sbjct: 3467 SMLYSTAKG 3475
>NP_001278238
          Length = 895

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LMYGTAE 8
           ++YGTAE
Sbjct: 554 ILYGTAE 560
>NP_612192
          Length = 956

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LMYGTAE 8
           ++YGTAE
Sbjct: 628 ILYGTAE 634
>NP_002561
          Length = 969

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LMYGTAE 8
           ++YGTAE
Sbjct: 628 ILYGTAE 634
>NP_001005280
          Length = 316

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SLMYGTA 7
           SL YGTA
Sbjct: 249 SLFYGTA 255
>NP_061824
          Length = 410

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLMYGTAEG 9
           S  YGTA+G
Sbjct: 217 SQAYGTAKG 225
>NP_001005226
          Length = 313

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SLMYGTA 7
           SL YGTA
Sbjct: 249 SLFYGTA 255
>NP_644670
          Length = 541

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SLMYGTAEG 9
           ++MYG  EG
Sbjct: 102 AVMYGETEG 110
>NP_006086
          Length = 1164

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLMYGTAEG 9
           +L YGTA G
Sbjct: 962 ALQYGTAFG 970
>NP_001098999
          Length = 1149

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLMYGTAEG 9
           +L YGTA G
Sbjct: 947 ALQYGTAFG 955
>NP_039229
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SLMYGTA 7
           SL YGTA
Sbjct: 248 SLFYGTA 254
>XP_006714052
          Length = 1000

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLMYGTAEG 9
           +L YGTA G
Sbjct: 798 ALQYGTAFG 806
>XP_005248100
          Length = 1164

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLMYGTAEG 9
           +L YGTA G
Sbjct: 962 ALQYGTAFG 970
>NP_149046
          Length = 357

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SLMYGTA 7
           SL YGTA
Sbjct: 249 SLFYGTA 255
>NP_001007467
          Length = 678

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LMYGTAEG 9
           +++GTA+G
Sbjct: 182 VLFGTADG 189
>NP_064630
          Length = 1543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LMYGTAEG 9
           +++GTA+G
Sbjct: 182 VLFGTADG 189
>NP_787079
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   SLMYGTAEG 9
           SL YGT  G
Sbjct: 249 SLFYGTGIG 257
>NP_001005191
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   SLMYGTAEG 9
           SL YGT  G
Sbjct: 249 SLFYGTGLG 257
>NP_056081
          Length = 581

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LMYGTAEG 9
           L YG AEG
Sbjct: 308 LPYGLAEG 315
>NP_001247420
          Length = 597

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LMYGTAEG 9
           L YG AEG
Sbjct: 324 LPYGLAEG 331
>XP_006723821
          Length = 334

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  LMYGTAEG 9
          L YG AEG
Sbjct: 61 LPYGLAEG 68
>XP_006723820
          Length = 334

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  LMYGTAEG 9
          L YG AEG
Sbjct: 61 LPYGLAEG 68
>XP_006723819
          Length = 614

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LMYGTAEG 9
           L YG AEG
Sbjct: 341 LPYGLAEG 348
>XP_005267114
          Length = 1543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LMYGTAEG 9
           +++GTA+G
Sbjct: 182 VLFGTADG 189
>NP_003544
          Length = 314

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   SLMYGTAEG 9
           SL YGT  G
Sbjct: 249 SLFYGTVIG 257
>NP_003545
          Length = 323

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   SLMYGTAEG 9
           SL YGT  G
Sbjct: 258 SLFYGTVIG 266
>NP_036509
          Length = 319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   SLMYGTAEG 9
           SL YGT  G
Sbjct: 248 SLFYGTGLG 256
>NP_001005190
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   SLMYGTAEG 9
           SL YGT  G
Sbjct: 249 SLFYGTCLG 257
>NP_001001958
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   SLMYGTAEG 9
           SL YGT  G
Sbjct: 249 SLFYGTGFG 257
>NP_001278220
          Length = 219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   MYGTAE 8
           +YGTAE
Sbjct: 175 VYGTAE 180
>NP_775082
          Length = 2721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   MYGTAEG 9
           MYG  EG
Sbjct: 456 MYGLGEG 462
>NP_003377
          Length = 2812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   MYGTAEG 9
           MYG  EG
Sbjct: 456 MYGLGEG 462
>NP_004906
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLMYGTAEG 9
           SLM G A+G
Sbjct: 257 SLMKGLAQG 265
>NP_997511
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLMYGTAEG 9
           SLM G A+G
Sbjct: 235 SLMKGLAQG 243
>NP_058198
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLMYGTAEG 9
           SLM G A+G
Sbjct: 257 SLMKGLAQG 265
>NP_997512
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLMYGTAEG 9
           SLM G A+G
Sbjct: 254 SLMKGLAQG 262
>NP_722523
          Length = 946

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   YGTAEG 9
           YG AEG
Sbjct: 527 YGVAEG 532
>NP_997510
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLMYGTAEG 9
           SLM G A+G
Sbjct: 259 SLMKGLAQG 267
>NP_997057
          Length = 677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLMYGTAEG 9
           SLM G A+G
Sbjct: 268 SLMKGLAQG 276
>NP_065201
          Length = 893

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   YGTAEG 9
           YG AEG
Sbjct: 474 YGVAEG 479
>XP_006722679
          Length = 2128

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    LMYGTA 7
            L+YGTA
Sbjct: 1624 LLYGTA 1629
>XP_005248797
          Length = 902

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   YGTAEG 9
           YG AEG
Sbjct: 483 YGVAEG 488
>XP_005248796
          Length = 937

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   YGTAEG 9
           YG AEG
Sbjct: 518 YGVAEG 523
>XP_005248795
          Length = 945

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   YGTAEG 9
           YG AEG
Sbjct: 526 YGVAEG 531
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.127    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 465,104
Number of extensions: 613
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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